0001782999 2023-01-01 2023-12-31 0001782999 dei:BusinessContactMember 2023-01-01 2023-12-31 0001782999 ptv:AmericanDepositarySharesMember 2023-01-01 2023-12-31 0001782999 ifrs-full:OrdinarySharesMember 2023-01-01 2023-12-31 0001782999 2023-12-31 0001782999 2022-01-01 2022-12-31 0001782999 2021-01-01 2021-12-31 0001782999 2022-12-31 0001782999 ifrs-full:IssuedCapitalMember 2020-12-31 0001782999 ifrs-full:SharePremiumMember 2020-12-31 0001782999 ifrs-full:TreasurySharesMember 2020-12-31 0001782999 ifrs-full:MergerReserveMember 2020-12-31 0001782999 ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember 2020-12-31 0001782999 ifrs-full:OtherReservesMember 2020-12-31 0001782999 ifrs-full:RetainedEarningsMember 2020-12-31 0001782999 ifrs-full:EquityAttributableToOwnersOfParentMember 2020-12-31 0001782999 ifrs-full:NoncontrollingInterestsMember 2020-12-31 0001782999 2020-12-31 0001782999 ifrs-full:RetainedEarningsMember 2021-01-01 2021-12-31 0001782999 ifrs-full:EquityAttributableToOwnersOfParentMember 2021-01-01 2021-12-31 0001782999 ifrs-full:NoncontrollingInterestsMember 2021-01-01 2021-12-31 0001782999 ifrs-full:IssuedCapitalMember 2021-01-01 2021-12-31 0001782999 ifrs-full:SharePremiumMember 2021-01-01 2021-12-31 0001782999 ifrs-full:OtherReservesMember 2021-01-01 2021-12-31 0001782999 ifrs-full:IssuedCapitalMember 2021-12-31 0001782999 ifrs-full:SharePremiumMember 2021-12-31 0001782999 ifrs-full:TreasurySharesMember 2021-12-31 0001782999 ifrs-full:MergerReserveMember 2021-12-31 0001782999 ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember 2021-12-31 0001782999 ifrs-full:OtherReservesMember 2021-12-31 0001782999 ifrs-full:RetainedEarningsMember 2021-12-31 0001782999 ifrs-full:EquityAttributableToOwnersOfParentMember 2021-12-31 0001782999 ifrs-full:NoncontrollingInterestsMember 2021-12-31 0001782999 2021-12-31 0001782999 ifrs-full:RetainedEarningsMember 2022-01-01 2022-12-31 0001782999 ifrs-full:EquityAttributableToOwnersOfParentMember 2022-01-01 2022-12-31 0001782999 ifrs-full:NoncontrollingInterestsMember 2022-01-01 2022-12-31 0001782999 ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember 2022-01-01 2022-12-31 0001782999 ifrs-full:IssuedCapitalMember 2022-01-01 2022-12-31 0001782999 ifrs-full:SharePremiumMember 2022-01-01 2022-12-31 0001782999 ifrs-full:TreasurySharesMember 2022-01-01 2022-12-31 0001782999 ifrs-full:OtherReservesMember 2022-01-01 2022-12-31 0001782999 ifrs-full:IssuedCapitalMember 2022-12-31 0001782999 ifrs-full:SharePremiumMember 2022-12-31 0001782999 ifrs-full:TreasurySharesMember 2022-12-31 0001782999 ifrs-full:MergerReserveMember 2022-12-31 0001782999 ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember 2022-12-31 0001782999 ifrs-full:OtherReservesMember 2022-12-31 0001782999 ifrs-full:RetainedEarningsMember 2022-12-31 0001782999 ifrs-full:EquityAttributableToOwnersOfParentMember 2022-12-31 0001782999 ifrs-full:NoncontrollingInterestsMember 2022-12-31 0001782999 ifrs-full:RetainedEarningsMember 2023-01-01 2023-12-31 0001782999 ifrs-full:EquityAttributableToOwnersOfParentMember 2023-01-01 2023-12-31 0001782999 ifrs-full:NoncontrollingInterestsMember 2023-01-01 2023-12-31 0001782999 ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember 2023-01-01 2023-12-31 0001782999 ifrs-full:IssuedCapitalMember 2023-01-01 2023-12-31 0001782999 ifrs-full:SharePremiumMember 2023-01-01 2023-12-31 0001782999 ifrs-full:TreasurySharesMember 2023-01-01 2023-12-31 0001782999 ifrs-full:OtherReservesMember 2023-01-01 2023-12-31 0001782999 ifrs-full:IssuedCapitalMember 2023-12-31 0001782999 ifrs-full:SharePremiumMember 2023-12-31 0001782999 ifrs-full:TreasurySharesMember 2023-12-31 0001782999 ifrs-full:MergerReserveMember 2023-12-31 0001782999 ifrs-full:ReserveOfExchangeDifferencesOnTranslationMember 2023-12-31 0001782999 ifrs-full:OtherReservesMember 2023-12-31 0001782999 ifrs-full:RetainedEarningsMember 2023-12-31 0001782999 ifrs-full:EquityAttributableToOwnersOfParentMember 2023-12-31 0001782999 ifrs-full:NoncontrollingInterestsMember 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember 2022-01-01 2022-12-31 0001782999 ptv:VedantaMember 2023-03-01 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:AlivioMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:AlivioMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:AlivioMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:AlivioMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:AlivioMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:AlivioMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EntregaMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EntregaMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EntregaMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EntregaMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EntregaMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EntregaMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechLYTMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechLYTMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechLYTMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechLYTMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechLYTMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechLYTMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechLYT100Member 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechLYT100Member 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechLYT100Member 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechLYT100Member 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechLYT100Member 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechLYT100Member 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechManagementMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechManagementMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechManagementMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechManagementMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechManagementMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechManagementMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechHealthMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechHealthMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechHealthMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechHealthMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechHealthMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechHealthMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:SondeMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:SondeMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:SondeMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:SondeMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:SondeMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:SondeMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:AkiliInteractiveLabsMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:AkiliInteractiveLabsMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:AkiliInteractiveLabsMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:AkiliInteractiveLabsMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:AkiliInteractiveLabsMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:AkiliInteractiveLabsMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:GelesisMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:GelesisMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:GelesisMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:GelesisMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:KarunaMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:KarunaMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:KarunaMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:KarunaMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:KarunaMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:KarunaMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VedantaBiosciencesMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VedantaBiosciencesMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VedantaBiosciencesMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VedantaBiosciencesMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VedantaBiosciencesMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VedantaBiosciencesMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VedantaBiosciencesSecuritiesCorpMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VedantaBiosciencesSecuritiesCorpMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VedantaBiosciencesSecuritiesCorpMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VedantaBiosciencesSecuritiesCorpMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VedantaBiosciencesSecuritiesCorpMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VedantaBiosciencesSecuritiesCorpMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VorMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VorMember 2023-01-01 2023-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VorMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VorMember 2022-01-01 2022-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:OrdinarySharesMember ptv:VorMember 2021-01-01 2021-12-31 0001782999 ptv:DeconsolidatedFormerSubsidiaryOperatingCompaniesMember ifrs-full:PreferenceSharesMember ptv:VorMember 2021-01-01 2021-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EndraHoldingsLLCMember 2023-01-01 2023-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EndraHoldingsLLCMember 2023-01-01 2023-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EndraHoldingsLLCMember 2022-01-01 2022-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EndraHoldingsLLCMember 2022-01-01 2022-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EndraHoldingsLLCMember 2021-01-01 2021-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EndraHoldingsLLCMember 2021-01-01 2021-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EnsofHoldingsLLCMember 2023-01-01 2023-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EnsofHoldingsLLCMember 2023-01-01 2023-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EnsofHoldingsLLCMember 2022-01-01 2022-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EnsofHoldingsLLCMember 2022-01-01 2022-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:EnsofHoldingsLLCMember 2021-01-01 2021-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:EnsofHoldingsLLCMember 2021-01-01 2021-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechSecuritiesCorpMember 2023-01-01 2023-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechSecuritiesCorpMember 2023-01-01 2023-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechSecuritiesCorpMember 2022-01-01 2022-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechSecuritiesCorpMember 2022-01-01 2022-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechSecuritiesCorpMember 2021-01-01 2021-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechSecuritiesCorpMember 2021-01-01 2021-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechSecuritiesIICorpMember 2023-01-01 2023-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechSecuritiesIICorpMember 2023-01-01 2023-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechSecuritiesIICorpMember 2022-01-01 2022-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechSecuritiesIICorpMember 2022-01-01 2022-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:OrdinarySharesMember ptv:PureTechSecuritiesIICorpMember 2021-01-01 2021-12-31 0001782999 ptv:NontradingHoldingCompaniesMember ifrs-full:PreferenceSharesMember ptv:PureTechSecuritiesIICorpMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:AppeeringMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:AppeeringMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:AppeeringMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:AppeeringMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:AppeeringMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:AppeeringMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:CommenseMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:CommenseMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:CommenseMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:CommenseMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:CommenseMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:CommenseMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:EnlightMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:EnlightMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:EnlightMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:EnlightMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:EnlightMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:EnlightMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:EnsofBiosystemsIncMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:EnsofBiosystemsIncMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:EnsofBiosystemsIncMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:EnsofBiosystemsIncMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:EnsofBiosystemsIncMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:EnsofBiosystemsIncMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:FollicaMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:FollicaMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:FollicaMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:FollicaMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:FollicaMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:FollicaMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:KnodeMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:KnodeMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:KnodeMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:KnodeMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:KnodeMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:KnodeMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:LibraBiosciencesIncMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:LibraBiosciencesIncMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:LibraBiosciencesIncMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:LibraBiosciencesIncMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:LibraBiosciencesIncMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:LibraBiosciencesIncMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:MandaraSciencesLLCMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:MandaraSciencesLLCMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:MandaraSciencesLLCMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:MandaraSciencesLLCMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:MandaraSciencesLLCMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:MandaraSciencesLLCMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:TalMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:TalMember 2023-01-01 2023-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:TalMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:TalMember 2022-01-01 2022-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:OrdinarySharesMember ptv:TalMember 2021-01-01 2021-12-31 0001782999 ptv:InactiveSubsidiariesMember ifrs-full:PreferenceSharesMember ptv:TalMember 2021-01-01 2021-12-31 0001782999 srt:MinimumMember ptv:LaboratoryAndManufacturingEquipmentMember 2023-01-01 2023-12-31 0001782999 srt:MaximumMember ptv:LaboratoryAndManufacturingEquipmentMember 2023-01-01 2023-12-31 0001782999 ifrs-full:FixturesAndFittingsMember 2023-01-01 2023-12-31 0001782999 srt:MinimumMember ifrs-full:ComputerEquipmentMember 2023-01-01 2023-12-31 0001782999 srt:MaximumMember ifrs-full:ComputerEquipmentMember 2023-01-01 2023-12-31 0001782999 srt:MinimumMember ifrs-full:LeaseholdImprovementsMember 2023-01-01 2023-12-31 0001782999 srt:MaximumMember ifrs-full:LeaseholdImprovementsMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AssociatesMember ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AssociatesMember ptv:GelesisMember 2022-01-01 2022-12-31 0001782999 ifrs-full:AssociatesMember ptv:GelesisMember 2021-01-01 2021-12-31 0001782999 ptv:ImbriumTherapeuticsLPMember 2021-01-01 2021-12-31 0001782999 ifrs-full:GoodsOrServicesTransferredAtPointInTimeMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GoodsOrServicesTransferredAtPointInTimeMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GoodsOrServicesTransferredAtPointInTimeMember 2021-01-01 2021-12-31 0001782999 ifrs-full:GoodsOrServicesTransferredOverTimeMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GoodsOrServicesTransferredOverTimeMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GoodsOrServicesTransferredOverTimeMember 2021-01-01 2021-12-31 0001782999 ptv:CustomerAMember ptv:Over10PercentOfRevenueMember 2023-01-01 2023-12-31 0001782999 ptv:CustomerAMember ptv:Over10PercentOfRevenueMember 2022-01-01 2022-12-31 0001782999 ptv:CustomerAMember ptv:Over10PercentOfRevenueMember 2021-01-01 2021-12-31 0001782999 ptv:CustomerBMember ptv:Over10PercentOfRevenueMember 2023-01-01 2023-12-31 0001782999 ptv:CustomerBMember ptv:Over10PercentOfRevenueMember 2022-01-01 2022-12-31 0001782999 ptv:CustomerBMember ptv:Over10PercentOfRevenueMember 2021-01-01 2021-12-31 0001782999 ptv:CustomerCMember ptv:Over10PercentOfRevenueMember 2023-01-01 2023-12-31 0001782999 ptv:CustomerCMember ptv:Over10PercentOfRevenueMember 2022-01-01 2022-12-31 0001782999 ptv:CustomerCMember ptv:Over10PercentOfRevenueMember 2021-01-01 2021-12-31 0001782999 ptv:Over10PercentOfRevenueMember 2023-01-01 2023-12-31 0001782999 ptv:Over10PercentOfRevenueMember 2022-01-01 2022-12-31 0001782999 ptv:Over10PercentOfRevenueMember 2021-01-01 2021-12-31 0001782999 ptv:WhollyOwnedProgramsMember 2023-12-31 0001782999 ptv:ControlledFoundedEntitiesMember 2023-12-31 0001782999 ptv:EstablishmentOfNewEntitiesMember 2024-01-31 0001782999 ptv:WhollyOwnedProgramsMember 2023-01-01 2023-12-31 0001782999 ptv:ControlledFoundedEntitiesMember 2023-01-01 2023-12-31 0001782999 ptv:ParentCompanyAndOtherMember 2023-01-01 2023-12-31 0001782999 ifrs-full:OperatingSegmentsMember 2023-01-01 2023-12-31 0001782999 ptv:ParentCompanyAndOtherMember 2023-12-31 0001782999 ifrs-full:OperatingSegmentsMember 2023-12-31 0001782999 ptv:WhollyOwnedProgramsMember 2022-01-01 2022-12-31 0001782999 ptv:ControlledFoundedEntitiesMember 2022-01-01 2022-12-31 0001782999 ptv:ParentCompanyAndOtherMember 2022-01-01 2022-12-31 0001782999 ifrs-full:OperatingSegmentsMember 2022-01-01 2022-12-31 0001782999 ptv:WhollyOwnedProgramsMember 2022-12-31 0001782999 ptv:ControlledFoundedEntitiesMember 2022-12-31 0001782999 ptv:ParentCompanyAndOtherMember 2022-12-31 0001782999 ifrs-full:OperatingSegmentsMember 2022-12-31 0001782999 ptv:WhollyOwnedProgramsMember 2021-01-01 2021-12-31 0001782999 ptv:ControlledFoundedEntitiesMember 2021-01-01 2021-12-31 0001782999 ptv:ParentCompanyAndOtherMember 2021-01-01 2021-12-31 0001782999 ifrs-full:OperatingSegmentsMember 2021-01-01 2021-12-31 0001782999 ptv:SondeMember 2022-01-01 2022-12-31 0001782999 ptv:KarunaAndVorMember 2022-01-01 2022-12-31 0001782999 ptv:AkiliMember 2022-01-01 2022-12-31 0001782999 ptv:GelesisMember 2022-01-01 2022-12-31 0001782999 ptv:VedantaMember 2023-01-01 2023-12-31 0001782999 ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ptv:KarunaMember 2023-01-01 2023-12-31 0001782999 ptv:VedantaMember 2023-01-01 2023-12-31 0001782999 ptv:VedantaMember 2023-12-31 0001782999 ptv:KarunaMember ifrs-full:OrdinarySharesMember 2021-02-09 0001782999 ptv:KarunaMember 2021-02-09 2021-02-09 0001782999 ptv:KarunaMember ifrs-full:OrdinarySharesMember 2021-11-09 0001782999 ptv:KarunaMember 2021-11-09 2021-11-09 0001782999 ptv:KarunaMember 2021-01-01 2021-12-31 0001782999 ptv:KarunaMember ifrs-full:OrdinarySharesMember 2022-08-08 0001782999 ptv:KarunaMember 2022-08-01 2022-09-30 0001782999 ptv:KarunaMember ifrs-full:OrdinarySharesMember 2023-12-31 0001782999 ptv:KarunaMember 2022-01-01 2022-12-31 0001782999 ptv:KarunaMember 2023-12-31 0001782999 ptv:BristolMyersSquibbMember ptv:KarunaMember 2023-12-31 0001782999 ptv:VorMember 2021-01-08 2021-01-08 0001782999 ptv:VorMember 2021-01-08 0001782999 ptv:VorMember ifrs-full:OrdinarySharesMember 2021-02-09 0001782999 ptv:VorMember 2021-02-09 0001782999 ptv:VorMember ifrs-full:OrdinarySharesMember 2021-02-10 0001782999 ptv:VorMember 2021-02-10 2021-02-10 0001782999 ptv:VorMember 2022-12-31 0001782999 ptv:VorMember 2022-08-01 2022-12-31 0001782999 ptv:VorMember 2023-01-01 2023-12-31 0001782999 ptv:VorMember 2022-01-01 2022-12-31 0001782999 ptv:VorMember 2021-01-01 2021-12-31 0001782999 ptv:VorMember 2023-12-31 0001782999 ptv:GelesisMember 2021-12-31 0001782999 ptv:GelesisMember 2021-01-01 2021-12-31 0001782999 ptv:CapstarMember 2022-01-13 0001782999 ptv:GelesisMember 2022-01-13 2022-01-13 0001782999 ptv:GelesisMember 2023-02-21 2023-02-21 0001782999 ptv:GelesisMember 2023-02-21 0001782999 ptv:GelesisMember 2023-05-01 2023-05-01 0001782999 ptv:GelesisMember 2023-05-01 0001782999 ptv:GelesisMember 2023-05-26 2023-05-26 0001782999 ptv:GelesisMember 2023-05-26 0001782999 ptv:GelesisMember 2023-05-31 0001782999 ptv:GelesisMember 2023-12-31 0001782999 ptv:SondeMember 2022-05-25 0001782999 ptv:SondeMember 2023-01-01 2023-12-31 0001782999 ptv:SondeMember 2022-01-01 2022-12-31 0001782999 ptv:SondeMember 2023-12-31 0001782999 ptv:AkiliMember ptv:SeriesDMember 2021-05-25 2021-05-25 0001782999 ptv:AkiliMember ptv:SeriesDMember 2021-05-25 0001782999 ptv:AkiliMember 2021-05-24 2021-05-24 0001782999 ptv:AkiliMember 2021-05-25 2021-05-25 0001782999 ptv:AkiliMember 2022-08-19 0001782999 ptv:AkiliMember 2022-08-19 2022-08-19 0001782999 ptv:AkiliMember 2023-01-01 2023-12-31 0001782999 ptv:AkiliMember 2021-01-01 2021-12-31 0001782999 ptv:GelesisMember 2020-12-31 0001782999 ptv:GelesisMember 2020-01-01 2020-12-31 0001782999 ptv:CapstarMember 2021-12-30 0001782999 ptv:CapstarMember 2023-12-31 0001782999 ptv:CapstarMember ptv:DerivativeAssetBackstopAgreementMember 2022-01-01 2022-12-31 0001782999 ptv:CapstarMember ptv:DerivativeAssetBackstopAgreementMember 2021-01-01 2021-12-31 0001782999 ptv:CapstarMember ptv:DerivativeAssetBackstopAgreementMember 2022-01-13 0001782999 ptv:GelesisHoldingsIncMember 2022-01-14 0001782999 ptv:GelesisMember 2022-01-13 0001782999 ptv:GelesisMember 2022-01-01 2022-01-13 0001782999 ptv:GelesisMember 2023-02-01 2023-02-21 0001782999 ptv:GelesisMember 2023-05-01 2023-05-31 0001782999 ifrs-full:TopOfRangeMember ptv:GelesisMember 2023-05-01 0001782999 ifrs-full:BottomOfRangeMember ptv:GelesisMember 2023-05-26 0001782999 ptv:SondeMember 2022-12-31 0001782999 ptv:PreferredA1SharesMember ptv:SondeMember 2022-05-25 0001782999 ptv:GelesisMember 2022-12-31 0001782999 ptv:UnsecuredPromissoryNoteReceivableMember ptv:GelesisMember 2022-07-27 0001782999 ptv:UnsecuredPromissoryNoteReceivableMember 2022-07-27 2022-07-27 0001782999 ptv:UnsecuredPromissoryNoteReceivableMember ptv:GelesisMember 2023-12-31 0001782999 ptv:UnsecuredPromissoryNoteReceivableMember ptv:GelesisMember 2022-12-31 0001782999 ptv:UnsecuredPromissoryNoteReceivableMember ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ptv:UnsecuredPromissoryNoteReceivableMember ptv:GelesisMember 2022-01-01 2022-12-31 0001782999 ptv:SeniorSecuredConvertiblePromissoryNoteMember ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ptv:ConvertibleNoteReceivableMember ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ptv:SeniorSecuredConvertiblePromissoryNoteMember ptv:GelesisMember 2023-12-31 0001782999 ptv:VedantaBiosciencesMember 2023-04-24 2023-04-24 0001782999 ptv:ConvertibleNoteReceivableMember ptv:VedantaBiosciencesMember 2023-04-24 0001782999 ptv:VedantaBiosciencesMember 2023-04-24 0001782999 ptv:VedantaBiosciencesMember 2023-01-01 2023-12-31 0001782999 ptv:NoteReceivableMember 2023-12-31 0001782999 ptv:NoteReceivableMember 2021-12-31 0001782999 ptv:NoteReceivableMember ptv:GelesisMember 2022-01-01 2022-12-31 0001782999 ptv:NoteReceivableMember 2022-01-01 2022-12-31 0001782999 ptv:NoteReceivableMember 2022-12-31 0001782999 ptv:NoteReceivableMember ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ptv:NoteReceivableMember ptv:VedantaMember 2023-01-01 2023-12-31 0001782999 ptv:NoteReceivableMember 2023-01-01 2023-12-31 0001782999 ptv:GeneralAndAdministrativeMember 2023-01-01 2023-12-31 0001782999 ptv:GeneralAndAdministrativeMember 2022-01-01 2022-12-31 0001782999 ptv:GeneralAndAdministrativeMember 2021-01-01 2021-12-31 0001782999 ptv:ResearchAndDevelopmentMember 2023-01-01 2023-12-31 0001782999 ptv:ResearchAndDevelopmentMember 2022-01-01 2022-12-31 0001782999 ptv:ResearchAndDevelopmentMember 2021-01-01 2021-12-31 0001782999 ptv:GeneralAndAdministrativeMember 2023-01-01 2023-12-31 0001782999 ptv:GeneralAndAdministrativeMember 2022-01-01 2022-12-31 0001782999 ptv:GeneralAndAdministrativeMember 2021-01-01 2021-12-31 0001782999 ptv:ResearchAndDevelopmentMember 2023-01-01 2023-12-31 0001782999 ptv:ResearchAndDevelopmentMember 2022-01-01 2022-12-31 0001782999 ptv:ResearchAndDevelopmentMember 2021-01-01 2021-12-31 0001782999 ptv:A2023PerformanceSharePlanMember 2015-06-01 2015-06-30 0001782999 srt:MinimumMember 2023-01-01 2023-12-31 0001782999 srt:MaximumMember 2023-01-01 2023-12-31 0001782999 ptv:A2015PerformanceSharePlanMember 2023-01-01 2023-12-31 0001782999 ptv:A2023PerformanceSharePlanMember 2023-01-01 2023-12-31 0001782999 ptv:PerformanceSharePlanMember 2023-01-01 2023-12-31 0001782999 ptv:RestrictedShareUnitsRSUMember 2020-12-31 0001782999 ptv:RestrictedShareUnitsRSUMember 2021-01-01 2021-12-31 0001782999 ptv:RestrictedShareUnitsRSUMember 2021-12-31 0001782999 ptv:RestrictedShareUnitsRSUMember 2022-01-01 2022-12-31 0001782999 ptv:RestrictedShareUnitsRSUMember 2022-12-31 0001782999 ptv:RestrictedShareUnitsRSUMember 2023-01-01 2023-12-31 0001782999 ptv:RestrictedShareUnitsRSUMember 2023-12-31 0001782999 srt:MinimumMember ptv:PerformanceMarketAndServiceBasedRSUMember 2023-01-01 2023-12-31 0001782999 srt:MaximumMember ptv:PerformanceMarketAndServiceBasedRSUMember 2023-01-01 2023-12-31 0001782999 ptv:PerformanceMarketAndServiceBasedRSUMember 2023-12-31 0001782999 ptv:PerformanceBasedRSUMember 2023-01-01 2023-12-31 0001782999 ifrs-full:RestrictedShareUnitsMember 2023-01-01 2023-12-31 0001782999 ifrs-full:RestrictedShareUnitsMember 2022-01-01 2022-12-31 0001782999 ifrs-full:RestrictedShareUnitsMember 2021-01-01 2021-12-31 0001782999 ifrs-full:RestrictedShareUnitsMember 2023-12-31 0001782999 2020-01-01 2020-12-31 0001782999 ptv:StockOptionsMember 2023-01-01 2023-12-31 0001782999 ptv:StockOptionsMember 2022-01-01 2022-12-31 0001782999 ptv:StockOptionsMember 2021-01-01 2021-12-31 0001782999 ptv:ExercisePriceRangeOneMember 2023-12-31 0001782999 ptv:ExercisePriceRangeOneMember 2023-01-01 2023-12-31 0001782999 ifrs-full:BottomOfRangeMember ptv:ExercisePriceRangeTwoMember 2023-12-31 0001782999 ifrs-full:TopOfRangeMember ptv:ExercisePriceRangeTwoMember 2023-12-31 0001782999 ptv:ExercisePriceRangeTwoMember 2023-12-31 0001782999 ptv:ExercisePriceRangeTwoMember 2023-01-01 2023-12-31 0001782999 ifrs-full:BottomOfRangeMember ptv:ExercisePriceRangeThreeMember 2023-12-31 0001782999 ifrs-full:TopOfRangeMember ptv:ExercisePriceRangeThreeMember 2023-12-31 0001782999 ptv:ExercisePriceRangeThreeMember 2023-12-31 0001782999 ptv:ExercisePriceRangeThreeMember 2023-01-01 2023-12-31 0001782999 ifrs-full:BottomOfRangeMember ptv:ExercisePriceRangeFourMember 2023-12-31 0001782999 ifrs-full:TopOfRangeMember ptv:ExercisePriceRangeFourMember 2023-12-31 0001782999 ptv:ExercisePriceRangeFourMember 2023-12-31 0001782999 ptv:ExercisePriceRangeFourMember 2023-01-01 2023-12-31 0001782999 ptv:EntregaMember 2022-12-31 0001782999 ptv:EntregaMember 2023-01-01 2023-12-31 0001782999 ptv:EntregaMember 2023-12-31 0001782999 ptv:FollicaMember 2022-12-31 0001782999 ptv:FollicaMember 2023-01-01 2023-12-31 0001782999 ptv:FollicaMember 2023-12-31 0001782999 ptv:VedantaBiosciencesMember 2022-12-31 0001782999 ptv:VedantaBiosciencesMember 2023-01-01 2023-12-31 0001782999 ptv:VedantaBiosciencesMember 2023-12-31 0001782999 ptv:EntregaMember 2021-12-31 0001782999 ptv:EntregaMember 2022-01-01 2022-12-31 0001782999 ptv:FollicaMember 2021-12-31 0001782999 ptv:FollicaMember 2022-01-01 2022-12-31 0001782999 ptv:SondeMember 2021-12-31 0001782999 ptv:SondeMember 2022-01-01 2022-12-31 0001782999 ptv:SondeMember 2022-12-31 0001782999 ptv:VedantaBiosciencesMember 2021-12-31 0001782999 ptv:VedantaBiosciencesMember 2022-01-01 2022-12-31 0001782999 ptv:AlivioMember 2020-12-31 0001782999 ptv:AlivioMember 2021-01-01 2021-12-31 0001782999 ptv:AlivioMember 2021-12-31 0001782999 ptv:EntregaMember 2020-12-31 0001782999 ptv:EntregaMember 2021-01-01 2021-12-31 0001782999 ptv:FollicaMember 2020-12-31 0001782999 ptv:FollicaMember 2021-01-01 2021-12-31 0001782999 ptv:SondeMember 2020-12-31 0001782999 ptv:SondeMember 2021-01-01 2021-12-31 0001782999 ptv:VedantaBiosciencesMember 2020-12-31 0001782999 ptv:VedantaBiosciencesMember 2021-01-01 2021-12-31 0001782999 ifrs-full:BottomOfRangeMember ptv:EntregaMember 2023-12-31 0001782999 ifrs-full:TopOfRangeMember ptv:EntregaMember 2023-12-31 0001782999 ptv:AllSubsidiariesMember ptv:StockIncentivePlanMember 2023-01-01 2023-12-31 0001782999 ptv:AllSubsidiariesMember ptv:StockIncentivePlanMember 2022-01-01 2022-12-31 0001782999 ptv:AllSubsidiariesMember ptv:StockIncentivePlanMember 2021-01-01 2021-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ptv:LaboratoryAndManufacturingEquipmentMember 2021-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:FixturesAndFittingsMember 2021-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ComputerEquipmentMember 2021-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LeaseholdImprovementsMember 2021-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ConstructionInProgressMember 2021-12-31 0001782999 ifrs-full:GrossCarryingAmountMember 2021-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ptv:LaboratoryAndManufacturingEquipmentMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:FixturesAndFittingsMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ComputerEquipmentMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LeaseholdImprovementsMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ConstructionInProgressMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ptv:LaboratoryAndManufacturingEquipmentMember 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:FixturesAndFittingsMember 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ComputerEquipmentMember 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LeaseholdImprovementsMember 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ConstructionInProgressMember 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ptv:LaboratoryAndManufacturingEquipmentMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:FixturesAndFittingsMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ComputerEquipmentMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LeaseholdImprovementsMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ConstructionInProgressMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ptv:LaboratoryAndManufacturingEquipmentMember 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:FixturesAndFittingsMember 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ComputerEquipmentMember 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LeaseholdImprovementsMember 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:ConstructionInProgressMember 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ptv:LaboratoryAndManufacturingEquipmentMember 2021-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:FixturesAndFittingsMember 2021-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ComputerEquipmentMember 2021-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:LeaseholdImprovementsMember 2021-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ConstructionInProgressMember 2021-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember 2021-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ptv:LaboratoryAndManufacturingEquipmentMember 2022-01-01 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:FixturesAndFittingsMember 2022-01-01 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ComputerEquipmentMember 2022-01-01 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:LeaseholdImprovementsMember 2022-01-01 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ConstructionInProgressMember 2022-01-01 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember 2022-01-01 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ptv:LaboratoryAndManufacturingEquipmentMember 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:FixturesAndFittingsMember 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ComputerEquipmentMember 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:LeaseholdImprovementsMember 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ConstructionInProgressMember 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ptv:LaboratoryAndManufacturingEquipmentMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:FixturesAndFittingsMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ComputerEquipmentMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:LeaseholdImprovementsMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ConstructionInProgressMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ptv:LaboratoryAndManufacturingEquipmentMember 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:FixturesAndFittingsMember 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ComputerEquipmentMember 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:LeaseholdImprovementsMember 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember ifrs-full:ConstructionInProgressMember 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAmortisationAndImpairmentMember 2023-12-31 0001782999 ptv:LaboratoryAndManufacturingEquipmentMember 2022-12-31 0001782999 ifrs-full:FixturesAndFittingsMember 2022-12-31 0001782999 ifrs-full:ComputerEquipmentMember 2022-12-31 0001782999 ifrs-full:LeaseholdImprovementsMember 2022-12-31 0001782999 ifrs-full:ConstructionInProgressMember 2022-12-31 0001782999 ptv:LaboratoryAndManufacturingEquipmentMember 2023-12-31 0001782999 ifrs-full:FixturesAndFittingsMember 2023-12-31 0001782999 ifrs-full:ComputerEquipmentMember 2023-12-31 0001782999 ifrs-full:LeaseholdImprovementsMember 2023-12-31 0001782999 ifrs-full:ConstructionInProgressMember 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LicencesMember 2021-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LicencesMember 2022-01-01 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LicencesMember 2022-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LicencesMember 2023-01-01 2023-12-31 0001782999 ifrs-full:GrossCarryingAmountMember ifrs-full:LicencesMember 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAndAmortisationMember ifrs-full:LicencesMember 2021-12-31 0001782999 ifrs-full:AccumulatedDepreciationAndAmortisationMember ifrs-full:LicencesMember 2022-01-01 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAndAmortisationMember ifrs-full:LicencesMember 2022-12-31 0001782999 ifrs-full:AccumulatedDepreciationAndAmortisationMember ifrs-full:LicencesMember 2023-01-01 2023-12-31 0001782999 ifrs-full:AccumulatedDepreciationAndAmortisationMember ifrs-full:LicencesMember 2023-12-31 0001782999 ifrs-full:LicencesMember 2022-12-31 0001782999 ifrs-full:LicencesMember 2023-12-31 0001782999 ptv:SondeMember 2023-01-01 2023-12-31 0001782999 ifrs-full:OrdinarySharesMember 2022-01-01 2022-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:PureTechHealthMember 2015-06-18 0001782999 ifrs-full:OrdinarySharesMember 2022-05-09 0001782999 ptv:JefferiesInternationalLimitedMember ifrs-full:OrdinarySharesMember 2022-05-09 0001782999 ifrs-full:OrdinarySharesMember 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember 2021-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember 2023-12-31 0001782999 ptv:RoyaltyPharmaMember 2023-03-22 2023-03-22 0001782999 2023-03-22 2023-03-22 0001782999 2023-03-23 2023-03-23 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:AtFairValueMember 2020-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ifrs-full:AtFairValueMember 2020-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:AtFairValueMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ifrs-full:AtFairValueMember 2021-01-01 2021-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:AtFairValueMember 2021-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ifrs-full:AtFairValueMember 2021-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:AtFairValueMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ifrs-full:AtFairValueMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:AtFairValueMember 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ifrs-full:AtFairValueMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:AtFairValueMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ifrs-full:AtFairValueMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:AtFairValueMember 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ifrs-full:AtFairValueMember 2023-12-31 0001782999 ptv:VedantaAndSondeMember 2023-01-01 2023-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2020-12-31 0001782999 ptv:VorMember ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2021-01-01 2021-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2021-01-01 2021-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2021-12-31 0001782999 ptv:SondeMember ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2022-01-01 2022-12-31 0001782999 ptv:GelesisMember ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2022-01-01 2022-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2022-01-01 2022-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:VedantaMember ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2023-01-01 2023-12-31 0001782999 ptv:GelesisMember ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2023-01-01 2023-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2023-01-01 2023-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level3OfFairValueHierarchyMember 2023-12-31 0001782999 ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:SondeMember 2023-12-31 0001782999 ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:VedantaMember 2023-12-31 0001782999 ptv:SondeMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:EquityValueMeasurementInputMember ptv:MarketBacksolveOPMMember 2023-12-31 0001782999 ptv:SondeMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:EquityValueMeasurementInputMember ptv:MarketBacksolveOPMMember 2023-01-01 2023-12-31 0001782999 ptv:SondeMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:TimeToLiquidityMeasurementInputMember ptv:MarketBacksolveOPMMember 2023-12-31 0001782999 ptv:SondeMember ifrs-full:Level3OfFairValueHierarchyMember ptv:TimeToLiquidityMeasurementInputMember ptv:MarketBacksolveApproachLeverageMonteCarloSimulationMember 2023-01-01 2023-12-31 0001782999 ptv:SondeMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:TimeToLiquidityMeasurementInputMember ptv:MarketBacksolveOPMMember 2023-01-01 2023-12-31 0001782999 ptv:SondeMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ifrs-full:HistoricalVolatilityForSharesMeasurementInputMember ptv:MarketBacksolveOPMMember 2023-12-31 0001782999 ptv:SondeMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ifrs-full:HistoricalVolatilityForSharesMeasurementInputMember ptv:MarketBacksolveOPMMember 2023-01-01 2023-12-31 0001782999 ptv:VedantaMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:EquityValueMeasurementInputMember ptv:MarketBacksolveApproachLeverageMonteCarloSimulationMember 2023-12-31 0001782999 ptv:VedantaMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:EquityValueMeasurementInputMember ptv:MarketBacksolveApproachLeverageMonteCarloSimulationMember 2023-01-01 2023-12-31 0001782999 ptv:VedantaMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:TimeToLiquidityMeasurementInputMember ptv:MarketBacksolveApproachLeverageMonteCarloSimulationMember 2023-12-31 0001782999 ptv:VedantaMember ifrs-full:Level3OfFairValueHierarchyMember ptv:TimeToLiquidityMeasurementInputMember ptv:MarketBacksolveApproachLeverageMonteCarloSimulationMember 2023-01-01 2023-12-31 0001782999 ptv:VedantaMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ptv:TimeToLiquidityMeasurementInputMember ptv:MarketBacksolveApproachLeverageMonteCarloSimulationMember 2023-01-01 2023-12-31 0001782999 ptv:VedantaMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ifrs-full:HistoricalVolatilityForSharesMeasurementInputMember ptv:MarketBacksolveApproachLeverageMonteCarloSimulationMember 2023-12-31 0001782999 ptv:VedantaMember ifrs-full:PreferenceSharesMember ifrs-full:Level3OfFairValueHierarchyMember ifrs-full:HistoricalVolatilityForSharesMeasurementInputMember ptv:MarketBacksolveApproachLeverageMonteCarloSimulationMember 2023-01-01 2023-12-31 0001782999 ptv:NoteReceivableMember ptv:GelesisMember 2022-12-31 0001782999 ptv:ConvertibleNoteReceivableMember ptv:VedantaBiosciencesMember 2023-01-01 2023-12-31 0001782999 ptv:ConvertibleNoteReceivableMember ptv:GelesisMember 2023-10-01 2023-10-31 0001782999 ifrs-full:CorporateLoansMember ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ifrs-full:CorporateLoansMember ifrs-full:Level1OfFairValueHierarchyMember 2023-12-31 0001782999 ifrs-full:CorporateLoansMember ifrs-full:Level2OfFairValueHierarchyMember 2023-12-31 0001782999 ifrs-full:CorporateLoansMember ifrs-full:Level3OfFairValueHierarchyMember 2023-12-31 0001782999 ifrs-full:CorporateLoansMember 2023-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember ifrs-full:Level1OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember ifrs-full:Level2OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember ifrs-full:Level3OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember 2023-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level1OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level2OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember 2023-12-31 0001782999 ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ifrs-full:Level1OfFairValueHierarchyMember 2023-12-31 0001782999 ifrs-full:Level2OfFairValueHierarchyMember 2023-12-31 0001782999 ifrs-full:Level3OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:Level1OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:Level2OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:Level3OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember ifrs-full:Level1OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember ifrs-full:Level2OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember ifrs-full:Level3OfFairValueHierarchyMember 2023-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember 2023-12-31 0001782999 ptv:ShortTermInvestmentMember ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ifrs-full:CorporateLoansMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ifrs-full:CorporateLoansMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ifrs-full:CorporateLoansMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ifrs-full:CorporateLoansMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ifrs-full:CorporateLoansMember 2022-12-31 0001782999 ptv:ShortTermInvestmentMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:ShortTermInvestmentMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShortTermInvestmentMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShortTermInvestmentMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShortTermInvestmentMember 2022-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShortTermNoteFromAssociateMember 2022-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:InvestmentsHeldAtFairValueMember 2022-12-31 0001782999 ifrs-full:TradeReceivablesMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ifrs-full:TradeReceivablesMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ifrs-full:TradeReceivablesMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ifrs-full:TradeReceivablesMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ifrs-full:TradeReceivablesMember 2022-12-31 0001782999 ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryWarrantLiabilityMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:SubsidiaryWarrantLiabilityMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryWarrantLiabilityMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryWarrantLiabilityMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryWarrantLiabilityMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:SubsidiaryNotesPayableMember 2022-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember ifrs-full:Level1OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember ifrs-full:Level2OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember ifrs-full:Level3OfFairValueHierarchyMember 2022-12-31 0001782999 ptv:ShareBasedLiabiltyAwardsMember 2022-12-31 0001782999 ptv:LoanMember 2023-12-31 0001782999 ptv:LoanMember 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember 2022-12-31 0001782999 ptv:LighthouseCapitalPartnersVILPMember ptv:LoanMember ptv:FollicaMember 2010-10-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:KnodeMember 2021-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:AppeeringMember 2021-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2021-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember 2021-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:KnodeMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:AppeeringMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember 2022-01-01 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:KnodeMember 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:AppeeringMember 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2022-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:KnodeMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:AppeeringMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember 2023-01-01 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:KnodeMember 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:AppeeringMember 2023-12-31 0001782999 ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2023-12-31 0001782999 ptv:PureTechAndThirdPartyMember ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2021-04-06 2021-11-24 0001782999 ptv:OutsideInvestorsMember ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2021-04-06 2021-11-24 0001782999 ptv:PureTechHealthCompanyMember ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2021-04-06 2021-11-24 0001782999 ptv:PureTechAndThirdPartyMember ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2022-03-01 2022-03-31 0001782999 ptv:OutsideInvestorsMember ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2022-03-01 2022-03-31 0001782999 ptv:PureTechHealthCompanyMember ptv:SubsidiaryConvertibleNotesMember ptv:SondeMember 2022-03-01 2022-03-31 0001782999 ifrs-full:OrdinarySharesMember ptv:EntregaMember 2023-01-01 2023-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:FollicaMember 2023-01-01 2023-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:EntregaMember 2022-01-01 2022-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:FollicaMember 2022-01-01 2022-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:VedantaBiosciencesMember 2022-01-01 2022-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:EntregaMember 2021-01-01 2021-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:FollicaMember 2021-01-01 2021-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:SondeMember 2021-01-01 2021-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:VedantaBiosciencesMember 2021-01-01 2021-12-31 0001782999 ptv:AlivioMember 2021-06-11 0001782999 ptv:AlivioMember 2021-06-11 2021-06-11 0001782999 ptv:AlivioMember 2023-01-01 2023-12-31 0001782999 2021-06-11 0001782999 2021-06-11 2021-06-11 0001782999 ptv:AlivioMember 2021-07-15 0001782999 ifrs-full:OrdinarySharesMember ptv:EntregaMember 2021-11-30 2021-11-30 0001782999 ifrs-full:OrdinarySharesMember ifrs-full:NoncontrollingInterestsMember ptv:EntregaAndVedantaMember 2021-01-01 2021-12-31 0001782999 ifrs-full:OrdinarySharesMember ptv:EntregaAndVedantaMember 2021-01-01 2021-12-31 0001782999 ifrs-full:OrdinarySharesMember ifrs-full:NoncontrollingInterestsMember ptv:VedantaBiosciencesMember 2023-01-01 2023-12-31 0001782999 ptv:OxfordFinanceLLCMember ifrs-full:GrossCarryingAmountMember ptv:VedantaBiosciencesMember 2020-09-30 0001782999 ptv:OxfordFinanceLLCMember ptv:VedantaBiosciencesMember ifrs-full:FloatingInterestRateMember 2020-09-30 0001782999 ptv:OxfordFinanceLLCMember ptv:VedantaBiosciencesMember ifrs-full:FloatingInterestRateMember 2020-09-15 0001782999 ptv:OxfordFinanceLLCMember ptv:VedantaBiosciencesMember 2020-09-01 2020-09-30 0001782999 ptv:OxfordFinanceLLCMember ptv:PreferredShareWarrantsMember ptv:VedantaBiosciencesMember 2021-09-21 0001782999 ptv:OxfordFinanceLLCMember ptv:VedantaBiosciencesMember 2022-12-31 0001782999 ifrs-full:NotLaterThanOneYearMember 2023-12-31 0001782999 ifrs-full:LaterThanOneYearAndNotLaterThanTwoYearsMember 2023-12-31 0001782999 ifrs-full:LaterThanTwoYearsAndNotLaterThanThreeYearsMember 2023-12-31 0001782999 ifrs-full:LaterThanThreeYearsAndNotLaterThanFourYearsMember 2023-12-31 0001782999 ifrs-full:LaterThanFourYearsAndNotLaterThanFiveYearsMember 2023-12-31 0001782999 ifrs-full:LaterThanFiveYearsMember 2023-12-31 0001782999 ptv:LeaseAt6TideStreetMember 2019-04-26 0001782999 ptv:LeaseAt6TideStreetMember 2019-04-26 2019-04-26 0001782999 ptv:GelesisMember 2019-06-26 0001782999 ptv:GelesisMember 2023-01-01 2023-12-31 0001782999 ptv:AlloniaLLCMember 2023-01-23 0001782999 ptv:AlloniaLLCMember 2023-01-23 2023-01-23 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ptv:WithinThreeMonthsMember 2023-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2023-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2023-12-31 0001782999 ptv:SubsidiaryNotesPayableMember 2023-12-31 0001782999 ptv:TradeAndOtherPayablesMember ifrs-full:CarryingAmountMember 2023-12-31 0001782999 ptv:TradeAndOtherPayablesMember ptv:WithinThreeMonthsMember 2023-12-31 0001782999 ptv:TradeAndOtherPayablesMember ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2023-12-31 0001782999 ptv:TradeAndOtherPayablesMember ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2023-12-31 0001782999 ptv:TradeAndOtherPayablesMember 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ptv:WithinThreeMonthsMember 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2023-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2023-12-31 0001782999 ptv:WithinThreeMonthsMember 2023-12-31 0001782999 ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2023-12-31 0001782999 ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2023-12-31 0001782999 ptv:LongTermLoanMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:LongTermLoanMember ptv:WithinThreeMonthsMember 2022-12-31 0001782999 ptv:LongTermLoanMember ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2022-12-31 0001782999 ptv:LongTermLoanMember ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2022-12-31 0001782999 ptv:LongTermLoanMember 2022-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ptv:WithinThreeMonthsMember 2022-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2022-12-31 0001782999 ptv:SubsidiaryNotesPayableMember ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2022-12-31 0001782999 ptv:TradeAndOtherPayablesMember ifrs-full:CarryingAmountMember 2022-12-31 0001782999 ptv:TradeAndOtherPayablesMember ptv:WithinThreeMonthsMember 2022-12-31 0001782999 ptv:TradeAndOtherPayablesMember ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2022-12-31 0001782999 ptv:TradeAndOtherPayablesMember ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2022-12-31 0001782999 ptv:TradeAndOtherPayablesMember 2022-12-31 0001782999 ptv:SubsidiaryWarrantLiabilityMember ptv:WithinThreeMonthsMember 2022-12-31 0001782999 ptv:SubsidiaryWarrantLiabilityMember ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2022-12-31 0001782999 ptv:SubsidiaryWarrantLiabilityMember ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ptv:WithinThreeMonthsMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2022-12-31 0001782999 ptv:SubsidiaryPreferredSharesMember ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2022-12-31 0001782999 ptv:WithinThreeMonthsMember 2022-12-31 0001782999 ifrs-full:LaterThanThreeMonthsAndNotLaterThanOneYearMember 2022-12-31 0001782999 ifrs-full:LaterThanOneYearAndNotLaterThanFiveYearsMember 2022-12-31 0001782999 ptv:KarunaVorAndAkiliMember 2023-12-31 0001782999 ptv:KarunaVorAndAkiliMember ifrs-full:EquityPriceRiskMember 2023-12-31 0001782999 ifrs-full:AssociatesMember ptv:GelesisMember 2022-12-31 0001782999 ifrs-full:AssociatesMember ptv:GelesisMember 2023-12-31 0001782999 ifrs-full:AssociatesMember ptv:GelesisMember 2020-01-01 2020-12-31 0001782999 ifrs-full:RelatedPartiesMember 2023-01-01 2023-12-31 0001782999 ptv:NonexecutiveDirectorsMember 2023-01-01 2023-12-31 0001782999 ptv:NonexecutiveDirectorsMember 2022-01-01 2022-12-31 0001782999 ptv:NonexecutiveDirectorsMember 2021-01-01 2021-12-31 0001782999 ifrs-full:RelatedPartiesMember 2022-01-01 2022-12-31 0001782999 ptv:DirectorsAndSeniorManagersMember ptv:ConvertibleNotesMember 2023-12-31 0001782999 ptv:DirectorsAndSeniorManagersMember ptv:ConvertibleNotesMember 2022-12-31 0001782999 ptv:EntregaMember ptv:DrRobertLangerMember ifrs-full:OrdinarySharesMember 2023-12-31 0001782999 ptv:EnlightMember ptv:DrRajuKucherlapatiMember ptv:ClassBCommonMember 2023-12-31 0001782999 ptv:AkiliMember ptv:DrJohnLaMattinaMember ifrs-full:OrdinarySharesMember 2023-12-31 0001782999 ptv:VedantaBiosciencesMember ptv:DrJohnLaMattinaMember ifrs-full:OrdinarySharesMember 2023-12-31 0001782999 ptv:KarunaMember ptv:DrBharattChowriraMember ifrs-full:OrdinarySharesMember 2023-12-31 0001782999 ptv:AppeeringMember ptv:DrJohnLaMattinaIndividuallyMember ptv:ConvertibleNotesMember 2023-12-31 0001782999 ptv:DirectorsAndSeniorManagersMember ifrs-full:OrdinarySharesMember 2023-12-31 0001782999 ptv:SeniorManagersMember ifrs-full:OrdinarySharesMember 2021-12-31 0001782999 ptv:SeniorManagersMember ifrs-full:OrdinarySharesMember 2023-12-31 0001782999 ptv:SeniorManagersMember ifrs-full:OrdinarySharesMember 2022-12-31 0001782999 srt:DirectorMember ifrs-full:OrdinarySharesMember 2021-12-31 0001782999 ifrs-full:AssociatesMember 2023-12-31 0001782999 ptv:FederalMember 2023-01-01 2023-12-31 0001782999 ptv:FederalMember 2022-01-01 2022-12-31 0001782999 ptv:FederalMember 2021-01-01 2021-12-31 0001782999 ptv:StateMember 2023-01-01 2023-12-31 0001782999 ptv:StateMember 2022-01-01 2022-12-31 0001782999 ptv:StateMember 2021-01-01 2021-12-31 0001782999 country:US ifrs-full:UnusedTaxLossesMember 2023-12-31 0001782999 country:US ifrs-full:UnusedTaxLossesMember 2022-12-31 0001782999 country:US ifrs-full:UnusedTaxCreditsMember 2023-12-31 0001782999 country:US ifrs-full:UnusedTaxCreditsMember 2022-12-31 0001782999 country:US ptv:ShareBasedPaymentsMember 2023-12-31 0001782999 country:US ptv:ShareBasedPaymentsMember 2022-12-31 0001782999 country:US ptv:CapitalizedResearchAndExperimentalExpendituresMember 2023-12-31 0001782999 country:US ptv:CapitalizedResearchAndExperimentalExpendituresMember 2022-12-31 0001782999 country:US ptv:InvestmentsInAssociatesMember 2023-12-31 0001782999 country:US ptv:InvestmentsInAssociatesMember 2022-12-31 0001782999 country:US ifrs-full:LeaseLiabilitiesMember 2023-12-31 0001782999 country:US ifrs-full:LeaseLiabilitiesMember 2022-12-31 0001782999 country:US ptv:FutureRoyaltiesMember 2023-12-31 0001782999 country:US ptv:FutureRoyaltiesMember 2022-12-31 0001782999 country:US ifrs-full:OtherTemporaryDifferencesMember 2023-12-31 0001782999 country:US ifrs-full:OtherTemporaryDifferencesMember 2022-12-31 0001782999 country:US 2023-12-31 0001782999 country:US 2022-12-31 0001782999 country:US ptv:InvestmentsHeldAtFairValueMember 2023-12-31 0001782999 country:US ptv:InvestmentsHeldAtFairValueMember 2022-12-31 0001782999 country:US ifrs-full:RightofuseAssetsMember 2023-12-31 0001782999 country:US ifrs-full:RightofuseAssetsMember 2022-12-31 0001782999 country:US ifrs-full:PropertyPlantAndEquipmentMember 2023-12-31 0001782999 country:US ifrs-full:PropertyPlantAndEquipmentMember 2022-12-31 0001782999 country:US ptv:InvestmentInAssociatesMember 2023-12-31 0001782999 country:US ptv:InvestmentInAssociatesMember 2022-12-31 0001782999 ptv:GrossAmountMember 2023-12-31 0001782999 ptv:TaxEffectedMember 2023-12-31 0001782999 ptv:GrossAmountMember 2022-12-31 0001782999 ptv:TaxEffectedMember 2022-12-31 0001782999 ptv:NotLaterThan10YearsMember ptv:GrossAmountMember 2023-12-31 0001782999 ptv:NotLaterThan10YearsMember ptv:TaxEffectedMember 2023-12-31 0001782999 ptv:NotLaterThan10YearsMember ptv:GrossAmountMember 2022-12-31 0001782999 ptv:NotLaterThan10YearsMember ptv:TaxEffectedMember 2022-12-31 0001782999 ifrs-full:LaterThanTenYearsMember ptv:GrossAmountMember 2023-12-31 0001782999 ifrs-full:LaterThanTenYearsMember ptv:TaxEffectedMember 2023-12-31 0001782999 ifrs-full:LaterThanTenYearsMember ptv:GrossAmountMember 2022-12-31 0001782999 ifrs-full:LaterThanTenYearsMember ptv:TaxEffectedMember 2022-12-31 0001782999 ptv:AvailableIndefinitelyMember ptv:GrossAmountMember 2023-12-31 0001782999 ptv:AvailableIndefinitelyMember ptv:TaxEffectedMember 2023-12-31 0001782999 ptv:AvailableIndefinitelyMember ptv:GrossAmountMember 2022-12-31 0001782999 ptv:AvailableIndefinitelyMember ptv:TaxEffectedMember 2022-12-31 0001782999 ptv:FederalMember 2021-12-31 0001782999 ptv:FederalMember ptv:OperatingLossCarryforwardsNotSubjectToExpirationMember 2023-12-31 0001782999 ptv:FederalMember 2023-12-31 0001782999 ptv:FederalMember 2022-12-31 0001782999 stpr:MA 2023-12-31 0001782999 stpr:MA 2022-12-31 0001782999 stpr:MA 2021-12-31 0001782999 ifrs-full:OrdinarySharesMember ifrs-full:MajorOrdinaryShareTransactionsMember 2024-02-29 0001782999 ptv:KarunaMember ptv:SaleOfInvestmentHeldAtFairValueMember 2024-03-01 2024-03-31 0001782999 ptv:KarunaMember ifrs-full:OrdinarySharesMember ptv:SaleOfInvestmentHeldAtFairValueMember 2024-03-31 0001782999 ifrs-full:MajorOrdinaryShareTransactionsMember 2024-03-01 2024-03-31 0001782999 ptv:SeaportTherapeuticsMember ptv:MajorFinancingActivityMember 2024-04-01 2024-04-30 0001782999 ptv:SeaportTherapeuticsMember ptv:MajorEquityInvestmentMember 2024-04-01 2024-04-30 0001782999 ptv:SeaportTherapeuticsMember ptv:MajorEquityInvestmentMember 2024-04-30 shares iso4217:USD iso4217:USD shares pure ptv:segment ptv:entity ptv:business_day ptv:employee iso4217:GBP shares ptv:pence ptv:simulation utr:Y ptv:asset ptv:vote ptv:tranche ptv:installment utr:sqft ptv:period 2023 FY 0001782999 false true P1Y P1Y P10Y3M 20-F false true 2023-12-31 --12-31 false false 001-39670 PURETECH HEALTH PLC X0 6 Tide Street 6 Tide Street Suite 400 Suite 400 Boston Boston MA MA 02210 02210 US US Bharatt Chowrira 617 482-2333 American Depositary Shares, each representing 10 ordinary shares, par value £0.01 per share PRTC NASDAQ Ordinary shares, par value £0.01 per share* NASDAQ 271853731 No No Yes Yes Accelerated Filer false true false International Financial Reporting Standards false 238 1118 PricewaterhouseCoopers LLP Boston, Massachusetts KPMG LLP London, United Kingdom27 April 2023 except for Note 4 and Note 20, as to which the date is 25 April 2024 750000 2090000 9979000 2580000 13528000 7409000 3330000 15618000 17388000 53295000 60991000 57199000 96235000 152433000 110471000 -146199000 -197807000 -150282000 61787000 27251000 0 77945000 -32060000 179316000 -122000 -29303000 -20925000 -27630000 0 0 -908000 8131000 1592000 111072000 -25981000 159983000 16012000 5799000 214000 3424000 3939000 4771000 2650000 137063000 9606000 10159000 0 0 5078000 138924000 5050000 -6055000 -27749000 -73703000 0 28220000 0 0 8390000 0 -36103000 -92783000 -58953000 30525000 -55719000 3756000 -66628000 -37065000 -62709000 92000 -166000 0 0 -213000 0 92000 -379000 0 -66535000 -37444000 -62709000 -65697000 -50354000 -60558000 -931000 13290000 -2151000 -66628000 -37065000 -62709000 -65604000 -50733000 -60558000 -931000 13290000 -2151000 -66535000 -37444000 -62709000 -0.24 -0.18 -0.21 -0.24 -0.18 -0.21 9536000 22957000 9825000 14281000 906000 831000 317841000 251892000 3185000 9147000 4600000 16501000 0 835000 878000 10000 346771000 316454000 2376000 11867000 11746000 10040000 4309000 11617000 0 450000 1628000 2124000 136062000 200229000 191081000 149866000 347201000 386192000 693973000 702647000 5461000 5455000 290262000 289624000 44626000 26492000 138506000 138506000 182000 89000 -9538000 -14478000 83820000 149516000 464066000 542220000 -5835000 5369000 458232000 547589000 110159000 0 52462000 19645000 18250000 24155000 0 10244000 3501000 4128000 184371000 58172000 0 2185000 3394000 4972000 44107000 54840000 3699000 2345000 0 47000 169000 27339000 0 5156000 51370000 96885000 235741000 155057000 693973000 702647000 285885025 5417000 288978000 0 0 138506000 469000 -24050000 260429000 669748000 -16209000 653539000 -60558000 -60558000 -2151000 -62709000 -60558000 -60558000 -2151000 -62709000 1911560 27000 326000 352000 352000 615000 615000 615000 7109000 7109000 6252000 13361000 -10749000 -10749000 -10749000 -6773000 -6773000 -6773000 -2582000 -2582000 -2582000 -9636000 -9636000 8668000 -968000 5988000 5988000 -5922000 66000 -6000 -6000 287796585 5444000 289303000 0 0 138506000 469000 -40077000 199871000 593515000 -9368000 584147000 -50354000 -50354000 13290000 -37065000 -379000 -379000 -379000 -379000 -50354000 -50733000 13290000 -37444000 11904000 11904000 577022 11000 321000 332000 332000 10595347 26492000 26492000 26492000 45000 45000 45000 8856000 8856000 4711000 13567000 788046 1528000 1528000 1528000 15171000 15171000 -15164000 7000 -4000 -4000 289161653 5455000 289624000 -10595347 -26492000 138506000 89000 -14478000 149516000 542220000 5369000 547589000 289161653 5455000 289624000 -10595347 -26492000 138506000 89000 -14478000 149516000 542220000 5369000 547589000 -65697000 -65697000 -931000 -66628000 92000 92000 92000 92000 -65697000 -65604000 -931000 -66535000 -9085000 -9085000 306506 6000 638000 239226 530000 -22000 1153000 1153000 7683526 19650000 19650000 19650000 3348000 3348000 277000 3625000 425219 986000 156000 1142000 1142000 -1458000 -1458000 1458000 0 -6000 -6000 289468159 5461000 290262000 -17614428 -44626000 138506000 182000 -9538000 83820000 464066000 -5835000 458232000 -66628000 -37065000 -62709000 4933000 8893000 7287000 4415000 14698000 13950000 -77945000 32060000 -179316000 265000 29303000 20925000 0 28220000 0 0 8390000 0 61787000 27251000 0 -6055000 -27749000 -73703000 -27630000 0 0 0 8163000 800000 -318000 -138000 -53000 1260000 0 30525000 -55719000 3756000 -5078000 -138924000 -5050000 9750000 -7734000 -617000 2834000 -862000 -5350000 -283000 2123000 -1407000 3844000 22033000 8338000 1374000 359000 -103000 150000 20696000 27766000 14454000 3460000 214000 1701000 3366000 3382000 -105917000 -178792000 -158274000 70000 2176000 5571000 865000 0 30000 175000 0 90000 0 19961000 0 0 5000000 500000 33309000 118710000 218125000 0 0 15000000 0 15000000 0 16850000 15000000 0 13784000 479000 0 178860000 248733000 0 244556000 50000000 0 0 415000 381000 68991000 -107223000 197375000 100000000 0 0 0 0 37610000 0 393000 2215000 3338000 4025000 3375000 1153000 332000 352000 0 0 -10749000 0 0 2582000 0 7000 66000 19650000 26492000 0 0 0 806000 -23000 -41000 -5000 78141000 -29827000 22727000 41215000 -315842000 61827000 149866000 465708000 403881000 191081000 149866000 465708000 25000 0 1142000 1528000 0 0 0 1841000 0 0 1010000 0 0 25797000 702000 0 3516000 0 8092000 0 2477000 0 15078000 1407000 1902000 0 4146000 0 15446000 0 0 3403000 24568000 15853000 323000 -123000 9085000 -11904000 55115000 8882000 20456000 18848000 -61787000 -27251000 13784000 479000 Material Accounting Policies<div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Description of Business</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Health plc (the “Parent”) is a public company incorporated, domiciled and registered in the United Kingdom (“UK”). The registered number is 09582467 and the registered address is 13th Floor, One Angel Court, London, EC2R 7HJ, United Kingdom.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Parent and its subsidiaries are together referred to as the “Group”.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The accounting policies set out below have, unless otherwise stated, been applied consistently to all periods presented in these group financial statements.</span></div><div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For presentation of the Consolidated Statement of Comprehensive Income/(Loss), the Group uses a classification based on the function of expenses, rather than based on their nature, as it is more representative of the format used for internal reporting and management purposes and is consistent with international practice.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Certain amounts in the Consolidated Financial Statements and accompanying notes may not add due to rounding. All percentages have been calculated using unrounded amounts.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Basis of Measurement </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Consolidated Financial Statements are prepared on the historical cost basis except that the following assets and liabilities are stated at their fair value: investments held at fair value, investments in notes from associates and liabilities classified as fair value through the profit or loss. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Use of Judgments and Estimates </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In preparing the Consolidated Financial Statements, management has made judgements, estimates and assumptions that affect the application of the Group’s accounting policies and the reported amounts of assets, liabilities, income and expenses. Actual results may differ from these estimates. Estimates and underlying assumptions are reviewed on an on-going basis.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Significant estimation is applied in determining the following:</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Financial instruments valuations (see Note 18. Financial Instruments): In accordance with IFRS 9, the Group carries certain financial assets and financial liabilities at fair value, with changes in fair value through profit and loss ("FVTPL"). Valuation of the aforementioned financial instruments (assets and liabilities) includes making significant estimates, specifically determining the appropriate valuation methodology and making certain estimates such as the future expected returns on the financial instrument in different scenarios, appropriate discount rate, volatility, and term to exit. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Significant judgement is also applied in determining the following:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Whether financial instruments should be classified as liability or equity (see Note 16. Subsidiary Preferred Shares.). The judgement includes an assessment of whether the financial instruments include contractual obligations of the Group to deliver cash or other financial assets or to exchange financial assets or financial liabilities with another party, and whether those obligations could be settled by the Group exchanging a fixed amount of cash or other financial assets for a fixed number of its own equity instruments. Further information about these critical judgements and estimates is included below under Financial Instruments.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Whether the power to control investees exists (see Note 5. Investments Held at Fair Value and Note 6. Investments in Associates and accounting policy with regard to Subsidiaries below). The judgement includes an assessment of whether the Group has (i) power over the investee; (ii) exposure, or rights, to variable returns from its involvement with the investee; and (iii) the ability to use its power over the investee to affect the amount of its own returns. The Group considers among others its voting shares, shareholder agreements, ability to appoint board members, representation on the board, rights to appoint management, de facto control, investee dependence on the Group, etc. If the power to control the investee exists, it consolidates the financial statements of such investee in the Consolidated Financial Statements of the Group. Upon issuance of new shares in an investee and/or a change in any shareholders or governance agreements, the Group reassesses its ability to control the investee based on the revised voting interest, revised board composition and revised subsidiary governance and management structure. When such new circumstances result in the Group losing its power to control the investee, the investee is deconsolidated. On March 1 2023 Vedanta was deconsolidated. Although the Group holds 47% of the voting rights and the other shareholders are widely dispersed, the Group does not have de facto control because the investor rights agreement stipulates that the relevant activities of Vedanta are directed by Vedanta's Board and the Group does not control Vedanta's Board decision making. Voting rights are not the dominant factor for directing Vedanta's relevant activities.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Whether the Group has significant influence over financial and operating policies of investees in order to determine if the Group should account for its investment as an associate based on IAS 28 or a financial instrument based on IFRS 9. (refer to Note 5. Investments Held at Fair Value and Note 6. Investments in Associates ). This judgement includes, among others, an assessment whether the Group has representation on the board of directors of the investee, whether the Group participates in the policy making processes of the investee, whether there is any interchange of managerial personnel, whether there is any essential technical information provided to the investee and if there are any transactions between the Group and the investee.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Upon determining that the Group does have significant influence over the financial and operating policies of an investee, if the Group holds more than a single instrument issued by its equity-accounted investee, judgement is required to determine whether the additional instrument forms part of the investment in the associate, which is accounted for under IAS 28 and </span></div><div style="padding-left:11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">scoped out of IFRS 9, or it is a separate financial instrument that falls in the scope of IFRS 9. This judgement includes an assessment of the characteristics of the financial instrument of the investee held by the Group and whether such financial instrument provides access to returns underlying an ownership interest.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">When the Group has other investments in an equity accounted investee that are not accounted for under IAS 28, judgement is required in determining if such investments constitute long-term interests ("LTI") for the purposes of IAS 28. This determination is based on the individual facts and circumstances and characteristics of each investment, but is driven, among other factors, by the intention and likelihood to settle the instrument through redemption or repayment in the foreseeable future, and whether or not the investment is likely to be converted to common stock or other equity instruments. After considering the individual facts and circumstances of the Group’s investment in its associate's preferred stock in the manner described above, including the long-term nature of such investment, the ability of the Group to convert its preferred stock investment to an investment in common shares and the likelihood of such conversion, the Group concluded that such investment was considered a long term interest.</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">In determining the appropriate accounting treatment for the Royalty Purchase Agreement, management applied significant judgement (refer to Note 17. Sale of Future Royalties Liability).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023, the Group had cash and cash equivalents of $191,081 and short-term investments of $136,062. Considering the Group’s financial position as of December 31, 2023, and its principal risks and opportunities, the Group prepared a going concern analysis covering a period of at least the twelve-month period from the date of signing the Consolidated Financial Statements ("the going concern period") utilizing realistic scenarios and applying a severe but plausible downside scenario. Even under the downside scenario, the analysis demonstrates the Group continues to maintain sufficient liquidity headroom and continues to comply with all financial obligations. The Board of Directors believe the Group and the Parent is adequately resourced to continue in operational existence for at least the twelve-month period from the date of signing the Consolidated Financial Statements. Accordingly, the Board of Directors considered it appropriate to adopt the going concern basis of accounting in preparing the Consolidated Financial Statements and the PureTech Health plc Financial Statements. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Basis of consolidation</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Consolidated Financial Statements as of December 31, 2023 and 2022, and for each of the years ended December 31, 2023, 2022 and 2021, comprises PureTech Health plc and its consolidated subsidiaries. Intra-group balances and transactions, and any unrealized income and expenses arising from intra-group transactions, are eliminated.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiaries </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As used in these financial statements, the term subsidiaries refers to entities that are controlled by the Group. Under applicable accounting rules, the Group controls an entity when it is exposed to, or has the rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its power over the entity. In assessing control, the Group takes into consideration potential voting rights, board representation, shareholders' agreements, ability to appoint board of directors and management, de facto control and other related factors. The financial statements of subsidiaries are included in the Consolidated Financial Statements from the date that control commences until the date that control ceases. Losses applicable to the non-controlling interests in a subsidiary are allocated to the non-controlling interests even if doing so causes the non-controlling interests to have a deficit balance.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">A list of all current and former subsidiaries organized with respect to classification as of December 31, 2023, and the Group’s total voting percentage, based on outstanding voting common and preferred shares as of December 31, 2023, 2022 and 2021, is outlined below. All current subsidiaries are domiciled within the United States and conduct business activities solely within the United States. </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:43.142%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.996%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="24" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Voting percentage at December 31, through the holdings in</span></div></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Subsidiary</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Common</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"><span style="font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%"> Preferred</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Common</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"><span style="font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%"> Preferred</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Common</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"><span style="font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%"> Preferred</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Subsidiary operating companies</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Alivio Therapeutics, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega, Inc. (indirectly held through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">77.3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">77.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">77.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech LYT, Inc. (formerly Ariya Therapeutics, Inc.)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech LYT 100, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Management, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">3</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Health LLC</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">3</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Deconsolidated former subsidiary operating companies</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sonde Health, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2,5</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">40.2</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">40.2 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">51.8 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Akili Interactive Labs, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2,6</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">14.6</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1,2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22.8 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4.8 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">19.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Karuna Therapeutics, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2,6</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.1 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5.6 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2, 4</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48.6 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences Securities Corp. (indirectly held through Vedanta)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2, 4</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48.6 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vor Biopharma Inc</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">.2,6</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3.9</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4.1 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.6 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Nontrading holding companies</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:justify"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.4pt;font-weight:400;line-height:120%">Endra Holdings, LLC (held indirectly through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.46pt;font-weight:400;line-height:120%;position:relative;top:-2.94pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">86.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:justify"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.4pt;font-weight:400;line-height:120%">Ensof Holdings, LLC (held indirectly through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.46pt;font-weight:400;line-height:120%;position:relative;top:-2.94pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">86.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Securities Corp.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Securities II Corp.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Inactive subsidiaries</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Appeering, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Commense Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">99.1</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">99.1 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">99.1 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Enlight Biosciences, LLC</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">86.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8pt;font-weight:400;line-height:120%">Ensof Biosystems, Inc. (held indirectly through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.2pt;font-weight:400;line-height:120%;position:relative;top:-2.8pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">57.7</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">28.3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica, LLC </span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">28.7</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">56.7</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">56.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">56.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Knode Inc. (indirectly held through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">86.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Libra Biosciences, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Mandara Sciences, LLC</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">98.3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">98.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">98.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tal Medical, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    On October 30, 2023, Gelesis ceased operations and filed a voluntary petition for relief under the United States bankruptcy code. See Note 6. Investments in Associates for details.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Registered address is Corporation Trust Center, 1209 Orange St., Wilmington, DE 19801, USA.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">3    Registered address is 2711 Centerville Rd., Suite 400, Wilmington, DE 19808, USA.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">4    On March 1, 2023, the Group lost control over Vedanta and Vedanta was deconsolidated from the Group’s financial statements, resulting in only the profits and losses generated by Vedanta through the deconsolidation date being included in the Group’s Consolidated Statement of Comprehensive Income/(Loss). See Notes 5. Investments Held at Fair Value for further details about the accounting for the investments in Vedanta subsequent to deconsolidation.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">5    On May 25, 2022, the Group lost control over Sonde and Sonde was deconsolidated from the Group’s financial statements, resulting in only the profits and losses generated by Sonde through the deconsolidation date being included in the Group’s Consolidated Statement of Comprehensive Income/(Loss). See Notes 5. Investments Held at Fair Value and 6. Investments in Associates for further details about the accounting for the investments in Sonde subsequent to deconsolidation.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">6    See Notes 5. Investments Held at Fair Value and 6. Investments in Associates for additional discussion on the Group's investment held in Akili, Karuna and Vor.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">7    Follica became inactive during 2023.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span><br/></span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in Subsidiary Ownership and Loss of Control </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the Group’s interest in a subsidiary that do not result in a loss of control are accounted for as equity transactions.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Where the Group loses control of a subsidiary, the assets and liabilities are derecognized along with any related non-controlling interest (“NCI”). Any interest retained in the former subsidiary is measured at fair value when control is lost. Any resulting gain or loss is recognized as profit or loss in the Consolidated Statement of Comprehensive Income/(Loss).</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Associates </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As used in these financial statements, the term associates are those entities in which the Group has no control but maintains significant influence over the financial and operating policies. Significant influence is presumed to exist when the Group holds between 20 and 50 percent of the voting power of an entity, unless it can be clearly demonstrated that this is not the case. The Group evaluates if it maintains significant influence over associates by assessing if the Group has the power to participate in the financial and operating policy decisions of the associate.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Application of the Equity Method to Associates </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Associates are accounted for using the equity method (equity accounted investees) and are initially recognized at cost, or if recognized upon deconsolidation, they are initially recorded at fair value at the date of deconsolidation. The Consolidated </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial Statements include the Group’s share of the total comprehensive income or loss of equity accounted investees, from the date that significant influence commences until the date that significant influence ceases. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">To the extent the Group holds interests in associates that are not providing access to returns underlying ownership interests, the instrument is accounted for in accordance with IFRS 9 as investments held at fair value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">When the Group’s share of losses exceeds its equity method investment in the investee, losses are applied against long-term interests, which are investments accounted for under IFRS 9. Investments are determined to be long-term interests when they are long-term in nature and in substance they form part of the Group's net investment in that associate. This determination is impacted by many factors, among others, whether settlement by the investee through redemption or repayment is planned or likely in the foreseeable future, whether the investment can be converted and/or is likely to be converted to common stock or other equity instrument and other factors regarding the nature of the investment. Whilst this assessment is dependent on many specific facts and circumstances of each investment, typically conversion features whereby the investment is likely to convert to common stock or other equity instruments would point to the investment being a long-term interest. Similarly, where the investment is not planned or likely to be settled through redemption or repayment in the foreseeable future, this would indicate that the investment is a long-term interest. When the net investment in the associate, which includes the Group’s investments in other long-term interests, is reduced to nil, recognition of further losses is discontinued except to the extent that the Group has incurred legal or constructive obligations or made payments on behalf of an investee.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has adopted the amendments to IAS 28 Investments in Associates that addresses the dual application of IAS 28 and IFRS 9 when equity method losses are applied against long-term interests. The amendments provide the annual sequence in which both standards are to be applied in such a case. The Group has applied the equity method losses to the long-term interests presented as part of Investments held at fair value subsequent to remeasuring such investments to their fair value at balance sheet date.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sale of Future Royalties Liability</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group accounts for the sale of future royalties liability as a financial liability, as it continues to hold the rights under the royalty bearing licensing agreement and has a contractual obligation to deliver cash to an investor for a portion of the royalty it receives. Interest on the sale of future royalties liability is recognized using the effective interest rate over the life of the related royalty stream.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The sale of future royalties liability and the related interest expense are based on the Group’s current estimates of future royalties expected to be paid over the life of the arrangement. Forecasts are updated periodically as new data is obtained. Any increases, decreases or a shift in timing of estimated cash flows require the Group to re-calculate the amortized cost of the sale of future royalties liability as the present value of the estimated future contractual cash flows that are discounted at the liability’s original effective interest rate. The adjustment is recognized immediately in profit or loss as income or expense.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial Instruments </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Classification </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group classifies its financial assets in the following measurement categories:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Those to be measured subsequently at fair value either through other comprehensive income "FVOCI", or through profit or loss "FVTPL", and</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Those to be measured at amortized cost.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The classification depends on the Group’s business model for managing the financial assets and the contractual terms of the cash flows.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For assets measured at fair value, gains and losses are recorded in profit or loss. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Measurement </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">At initial recognition, the Group measures a financial asset at its fair value plus, in the case of a financial asset not at FVTPL, transaction costs that are directly attributable to the acquisition of the financial asset. Transaction costs of financial assets that are carried at FVTPL are expensed.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Impairment </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group assesses on a forward-looking basis the expected credit losses associated with its debt instruments carried at amortized cost. For trade receivables, the Group applies the simplified approach permitted by IFRS 9, which requires expected lifetime losses to be recognized from initial recognition of the receivables.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Financial Assets </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s financial assets consist of cash and cash equivalents, investments in debt securities, trade and other receivables, notes, restricted cash deposits and investments in equity securities. The Group’s financial assets are virtually all classified into the following categories: investments held at fair value, notes, trade and other receivables, short-term investments and cash and cash equivalents. The Group determines the classification of financial assets at initial recognition depending on the purpose for which the financial assets were acquired.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value are investments in equity instruments. Such investments consist of the Group's minority interest holdings where the Group has no significant influence or preferred share investments that are not providing access to returns underlying ownership interests and are categorized as debt instruments that are presented at fair value through profit and loss because the amounts receivable do not represent solely payments of principal and interest. These financial assets are initially measured at fair value and subsequently re-measured at fair value at each reporting date. The Group has elected to record the changes in fair values for the financial assets falling under this category through profit and loss. Please refer to Note 5. Investments Held at Fair Value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the fair value of financial assets at FVTPL are recognized in other income/(expense) in the Consolidated Statement of Comprehensive Income/(Loss) as applicable. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The notes from an associate, since their contractual terms do not consist solely of cash flow payments of principal and interest on the principal amount outstanding, are initially and subsequently measured at fair value, with changes in fair value recognized through profit and loss.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash and cash equivalents consist of demand deposits with banks and other financial institutions and highly liquid instruments with original maturities of three months or less at the date of purchase. Cash and cash equivalents are carried at cost, which approximates their fair value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term investments consist of short-term US treasury bills that are held to maturity. The contractual terms consist solely of payment of the principal and interest and the Group's business model is to hold the treasury bills to maturity. As such, such short-term investments are recorded at amortized cost. As of balance sheet date, amortized cost approximated the fair value of such short-term investments.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other receivables are non-derivative financial assets with fixed and determinable payments that are not quoted on active markets. These financial assets are carried at the amounts expected to be received less any expected lifetime losses. Such losses are determined taking into account previous experience, credit rating and economic stability of counterparty and economic conditions. When a trade receivable is determined to be uncollectible, it is written off against the available provision. As of balance sheet date, the Group did not record any such expected lifetime losses related to the outstanding trade and other receivable balances. Trade and other receivables are included in current assets, unless maturities are greater than 12 months after the end of the reporting period.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Financial Liabilities </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s financial liabilities primarily consist of trade and other payables, and preferred shares. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The majority of the Group’s subsidiaries have preferred shares and certain notes payable with embedded derivatives, which are classified as current liabilities. When the Group has preferred shares and notes with embedded derivatives that qualify for bifurcation, the Group has elected to account for the entire instrument as FVTPL after determining under IFRS 9 that the instrument qualifies to be accounted for under such FVTPL method.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group derecognizes a financial liability when its contractual obligations are discharged, cancelled or expire.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity Instruments Issued by the Group </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial instruments issued by the Group are treated as equity only to the extent that they meet the following two conditions, in accordance with IAS 32:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:4.26pt">They include no contractual obligations upon the Group to deliver cash or other financial assets or to exchange financial assets or financial liabilities with another party under conditions that are potentially unfavorable to the Group; and</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:4.26pt">Where the instrument will or may be settled in the Group’s own equity instruments, it is either a non-derivative that includes no obligation to deliver a variable number of the Group’s own equity instruments or is a derivative that will be settled by the Group exchanging a fixed amount of cash or other financial assets for a fixed number of its own equity instruments.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">To the extent that this definition is not met, the financial instrument is classified as a financial liability. Where the instrument so classified takes the legal form of the Group’s own shares, the amounts presented in the Group's shareholders' equity exclude amounts in relation to those shares.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the fair value of liabilities at FVTPL are recognized in net finance income /(costs) in the Consolidated Statement of Comprehensive Income/(Loss) as applicable. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">IFRS 15, Revenue from Contracts with Customers </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The standard establishes a five-step principle-based approach for revenue recognition and is based on the concept of recognizing an amount that reflects the consideration for performance obligations only when they are satisfied and the control of goods or services is transferred.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The majority of the Group’s contract revenue is generated from licenses and services, some of which are part of collaboration arrangements. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Management reviewed contracts where the Group received consideration in order to determine whether or not they should be accounted for in accordance with IFRS 15. To date, the Group has entered into transactions that generate revenue and meet the scope of either IFRS 15 or IAS 20 Accounting for Government Grants. Contract revenue is recognized at either a point-in-time or over time, depending on the nature of the performance obligations.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group accounts for agreements that meet the definition of IFRS 15 by applying the following five step model:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Identify the contract(s) with a customer – A contract with a customer exists when (i) the Group enters into an enforceable contract with a customer that defines each party’s rights regarding the goods or services to be transferred and identifies the payment terms related to those goods or services, (ii) the contract has commercial substance and, (iii) the Group determines that collection of substantially all consideration for goods or services that are transferred is probable based on the customer’s intent and ability to pay the promised consideration.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Identify the performance obligations in the contract – Performance obligations promised in a contract are identified based on the goods or services that will be transferred to the customer that are both capable of being distinct, whereby the customer can benefit from the good or service either on its own or together with other resources that are readily available from third parties or from the Group, and are distinct in the context of the contract, whereby the transfer of the goods or services is separately identifiable from other promises in the contract.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Determine the transaction price – The transaction price is determined based on the consideration to which the Group will be entitled in exchange for transferring goods or services to the customer. To the extent the transaction price includes variable consideration, the Group estimates the amount of variable consideration that should be included in the transaction price utilizing either the expected value method or the most likely amount method depending on the nature of the variable consideration. Variable consideration is included in the transaction price if, in the Group’s judgement, it is probable that a significant future reversal of cumulative revenue under the contract will not occur. </span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Allocate the transaction price to the performance obligations in the contract – If the contract contains a single performance obligation, the entire transaction price is allocated to the single performance obligation. Contracts that contain multiple performance obligations require an allocation of the transaction price to each performance obligation based on a relative standalone selling price basis. </span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Recognize revenue when (or as) the Group satisfies a performance obligation – The Group satisfies performance obligations either over time or at a point in time as discussed in further detail below. Revenue is recognized at the time the related performance obligation is satisfied by transferring a promised good or service to a customer.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revenue generated from services agreements (typically where licenses and related services were combined into one performance obligation) is determined to be recognized over time when it can be determined that the services meet one of the following: (a) the customer simultaneously receives and consumes the benefits provided by the entity’s performance as the entity performs; (b) the entity’s performance creates or enhances an asset that the customer controls as the asset is created or enhanced; or (c) the entity’s performance does not create an asset with an alternative use to the entity and the entity has an enforceable right to payment for performance completed to date.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">It was determined that the Group has contracts that meet criteria (a), since the customer simultaneously receives and consumes the benefits provided by the Group’s performance as the Group performs. Therefore revenue is recognized over time using the input method based on costs incurred to date as compared to total contract costs. The Group believes that in research and development service type agreements using costs incurred to date represents the most faithful depiction of the entity’s performance towards complete satisfaction of a performance obligation.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revenue from licenses that are not part of a combined performance obligation are recognized at a point in time due to the licenses relating to intellectual property that has significant stand-alone functionality and as such represent a right to use the entity's intellectual property as it exists at the point in time at which the license is granted.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Royalty income received in respect of licensing agreements when the license of intellectual property is the predominant item in the arrangement is recognized as the related third-party sales in the licensee occur.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amounts that are receivable or have been received per contractual terms but have not been recognized as revenue since performance has not yet occurred or has not yet been completed are recorded as deferred revenue. The Group classifies as non-current deferred revenue amounts received for which performance is expected to occur beyond one year or one operating cycle.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Grant Revenue</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group recognizes grants from governmental agencies as grant revenue in the Consolidated Statement of Comprehensive Income/(Loss), gross of the expenditures that were related to obtaining the grant, when there is reasonable assurance that the Group will comply with the conditions within the grant agreement and there is reasonable assurance that payments under the grants will be received. The Group evaluates the conditions of each grant as of each reporting date to ensure that the Group has reasonable assurance of meeting the conditions of each grant arrangement and that it is expected that the grant payment will be received as a result of meeting the necessary conditions.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group submits qualifying expenses for reimbursement after the Group has incurred the research and development expense. The Group records an unbilled receivable upon incurring such expenses. In cases in which the grant revenue is received prior to the expenses being incurred or recognized, the amounts received are deferred until the related expense is incurred and/or recognized. Grant revenue is recognized in the Consolidated Statement of Comprehensive Income/(Loss) at the time in which the Group recognizes the related reimbursable expense for which the grant is intended to compensate.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Functional and Presentation Currency </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Consolidated Financial Statements are presented in United States dollars (“US dollars”). The functional currency of all members of the Group is the U.S. dollar. The Group's share in foreign exchange differences in associates were reported in other comprehensive income/(loss).</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Foreign Currency </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Transactions in foreign currencies are translated to the respective functional currencies of Group entities at the foreign exchange rate ruling at the date of the transaction. Monetary assets and liabilities denominated in foreign currencies at the balance sheet date are retranslated to the functional currency at the foreign exchange rate ruling at that date. Foreign exchange differences arising on remeasurement are recognized in the Consolidated Statement of Comprehensive Income/(Loss). Non-monetary assets and liabilities that are measured in terms of historical cost in a foreign currency are translated using the exchange rate at the date of the transaction. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share Capital </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Ordinary shares are classified as equity. The Group's equity is comprised of share capital, share premium, merger reserve, other reserve, translation reserve, and retained earnings/accumulated deficit.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Treasury Shares</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Treasury shares are recognized at cost and are deducted from shareholders' equity. No gain or loss is recognized in profit and loss for the purchase, sale, re-issue or cancellation of the Group's own equity shares.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Property and Equipment </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Property and equipment is stated at cost less accumulated depreciation and any accumulated impairment losses. Cost includes expenditures that are directly attributable to the acquisition of the asset. Assets under construction represent leasehold improvements and machinery and equipment to be used in operations or research and development activities. When parts of an item of property and equipment have different useful lives, they are accounted for as separate items (major components) of property and equipment. Depreciation is calculated using the straight-line method over the estimated useful life of the related asset: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:47.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:50.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Laboratory and manufacturing equipment</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2-8 years</span></div></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Furniture and fixtures</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7 years</span></div></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Computer equipment and software</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1-5 years</span></div></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Leasehold improvements</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5-10 years, or the remaining term of the lease, if shorter</span></div></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation methods, useful lives and residual values are reviewed at each balance sheet date.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Intangible Assets </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Intangible assets, which include purchased patents and licenses with finite useful lives, are carried at historical cost less accumulated amortization, if amortization has commenced. Intangible assets with finite lives are amortized from the time they are available for their intended use. Amortization is calculated using the straight-line method to allocate the costs of patents and licenses over their estimated useful lives. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development intangible assets, which are still under development and have accordingly not yet obtained marketing approval, are presented as In-Process Research and Development (IPR&amp;D). The cost of IPR&amp;D represents upfront payments as well as additional contingent payments based on development, regulatory and sales milestones related to certain license agreement where the Group licenses IP from a third party. These milestones are capitalized as the milestone is triggered. See Note 25. Commitments and Contingencies. IPR&amp;D is not amortized since it is not yet available for its intended use, but it is evaluated for potential impairment on an annual basis or more frequently when facts and circumstances warrant.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment of Non-Financial Assets </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group reviews the carrying amounts of its property and equipment and intangible assets at each reporting date to determine whether there are indicators of impairment. If any such indicators of impairment exist, then an asset’s recoverable amount is estimated. The recoverable amount is the higher of an asset’s fair value less cost of disposal and value in use.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s IPR&amp;D intangible assets are not yet available for their intended use. As such, they are tested for impairment at least annually. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">An impairment loss is recognized when an asset’s carrying amount exceeds its recoverable amount. For the purposes of impairment testing, assets are grouped at the lowest levels for which there are largely independent cash flows. If a non- financial asset instrument is impaired, an impairment loss is recognized in the Consolidated Statement of Comprehensive Income/(Loss).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments in associates are considered impaired if, and only if, objective evidence indicates that one or more events, which occurred after the initial recognition, have had an impact on the future cash flows from the net investment and that impact can be reliably estimated. If an impairment exists, the Group measures an impairment by comparing the carrying value of the net investment in the associate to its recoverable amount and recording any excess as an impairment loss. See Note 6. Investments in Associates for impairment recorded in respect of an investment in associate during the year ended December 31, 2022.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Employee Benefits </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Short-Term Employee Benefits </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term employee benefit obligations are measured on an undiscounted basis and expensed as the related service is provided. A liability is recognized for the amount expected to be paid if the Group has a present legal or constructive obligation due to past service provided by the employee, and the obligation can be estimated reliably.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Defined Contribution Plans </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">A defined contribution plan is a post-employment benefit plan under which an entity pays fixed contributions into a separate entity and has no legal or constructive obligation to pay further amounts. Obligations for contributions to defined contribution plans are recognized as an employee benefit expense in the periods during which related services are rendered by employees. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Share-based Payments </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payment arrangements, in which the Group receives goods or services as consideration for its own equity instruments, are accounted for as equity-settled share-based payment transactions (except certain restricted stock units - see below) in accordance with IFRS 2, regardless of how the equity instruments are obtained by the Group. The grant date fair value of employee share-based payment awards is recognized as an expense with a corresponding increase in equity over the requisite service period related to the awards. The amount recognized as an expense is adjusted to reflect the actual number of awards for which the related service and non-market performance conditions are expected to be met, such that the amount ultimately recognized as an expense is based on the number of awards that do meet the related service and non-market performance conditions at the vesting date. For share-based payment awards with market conditions, the grant date fair value is measured to reflect such conditions and there is no true-up for differences between expected and actual outcomes.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Certain restricted stock units are treated as liability settled awards starting in 2021. Such awards are remeasured at every reporting date until settlement date and are recognized as compensation expense over the requisite service period. Differences in remeasurement are recognized in profit and loss. The cumulative cost that will ultimately be recognized in respect of these awards will equal to the amount at settlement. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of the awards is measured using option pricing models and other appropriate models, which take into account the terms and conditions of the awards granted. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Development Costs </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Expenditures on research activities are recognized as incurred in the Consolidated Statement of Comprehensive Income/(Loss). In accordance with IAS 38, development costs are capitalized only if the expenditure can be measured reliably, the product or process is technically and commercially feasible, future economic benefits are probable, the Group can demonstrate its ability to use or sell the intangible asset, the Group intends to and has sufficient resources to complete development and to use or sell the asset, and it is able to measure reliably the expenditure attributable to the intangible asset during its development. The point at which technical feasibility is determined to have been reached is, generally, when regulatory approval has been received where applicable. Management determines that commercial viability has been reached when a clear market and pricing point have been identified, which may coincide with achieving meaningful recurring sales. Otherwise, the development expenditure is recognized </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">as incurred in the Consolidated Statement of Comprehensive Income/(Loss). As of balance sheet date, the Group has not capitalized any development costs.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Provisions </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">A provision is recognized in the Consolidated Statement of Financial Position when the Group has a present legal or constructive obligation due to a past event that can be reliably measured, and it is probable that an outflow of economic benefits will be required to settle the obligation. Provisions are determined by discounting the expected future cash flows at a pre-tax rate that reflects risks specific to the liability.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Leases</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group leases real estate for use in operations. These leases have lease terms of approximately 10 years. The Group includes options that are reasonably certain to be exercised as part of the determination of the lease term. The group determines if an arrangement is a lease at inception of the contract in accordance with guidance detailed in IFRS 16. Right-of-use (ROU) assets represent the Group’s right to use an underlying asset for the lease term and lease liabilities represent the Group's obligation to make lease payments arising from the lease. Operating lease ROU assets and lease liabilities are recognized at commencement date based on the present value of the lease payments over the lease term. As most of the Group's leases do not provide an implicit rate, the Group used its estimated incremental borrowing rate, based on information available at commencement date, in determining the present value of future payments. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s leases are virtually all leases of real estate.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has elected to account for lease payments as an expense on a straight-line basis over the life of the lease for: </span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Leases with a term of 12 months or less and containing no purchase options; and </span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Leases where the underlying asset has a value of less than $5,000. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The right-of-use asset is depreciated on a straight-line basis and the lease liability gives rise to an interest charge. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Finance Income and Finance Costs </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Finance income consists of interest income on funds invested in money market funds and U.S. treasuries. Finance income is recognized as it is earned. Finance costs consist mainly of loan, notes and lease liability interest expenses, interest expense due to accretion of and adjustment to sale of future royalties liability as well as the changes in the fair value of financial liabilities carried at FVTPL (such changes can consist of finance income when the fair value of such financial liabilities decreases).</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Taxation </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax on the profit or loss for the year comprises current and deferred income tax. In accordance with IAS 12, tax is recognized in the Consolidated Statement of Comprehensive Income/(Loss) except to the extent that it relates to items recognized directly in equity.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Current income tax is the expected tax payable or receivable on the taxable income or loss for the year, using tax rates enacted or substantially enacted at the reporting date, and any adjustment to tax payable in respect of previous years.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax is recognized due to temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for taxation purposes. Deferred tax assets are recognized for unused tax losses, unused tax credits and deductible temporary differences to the extent that it is probable that future taxable profits will be available against which they can be used. Deferred tax assets with respect to investments in associates are recognized only to the extent that it is probable the temporary difference will reverse in the foreseeable future and taxable profit will be available against which the temporary difference can be utilized. Deferred tax assets are reviewed at each reporting date and are reduced to the extent that it is no longer probable that the related tax benefit will be realized.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax is measured at the tax rates that are expected to be applied to temporary differences when they reverse, using tax rates enacted or substantively enacted at the reporting date.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred income tax assets and liabilities are offset when there is a legally enforceable right to offset current tax assets against current tax liabilities and when the deferred income tax assets and liabilities relate to income taxes levied by the same taxation authority on either the same taxable entity or different taxable entities where there is an intention to settle the balances on a net basis.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Fair Value Measurements </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s accounting policies require that certain financial assets and certain financial liabilities be measured at their fair value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group uses valuation techniques that are appropriate in the circumstances and for which sufficient data are available to measure fair value, maximizing the use of relevant observable inputs and minimizing the use of unobservable inputs. Fair values are categorized into different levels in a fair value hierarchy based on the inputs used in the valuation techniques as follows:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Level 1: quoted prices (unadjusted) in active markets for identical assets or liabilities.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Level 2: inputs other than quoted prices included in Level 1 that are observable for the asset or liability, either directly (i.e. as prices) or indirectly (i.e. derived from prices).</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Level 3: inputs for the asset or liability that are not based on observable market data (unobservable inputs).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group recognizes transfers between levels of the fair value hierarchy at the end of the reporting period during which the change has occurred.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The carrying amount of cash and cash equivalents, accounts receivable, restricted cash, deposits, accounts payable, accrued expenses and other current liabilities in the Group’s Consolidated Statement of Financial Position approximates their fair value because of the short maturities of these instruments. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating Segments </span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating segments are reported in a manner that is consistent with the internal reporting provided to the chief operating decision maker (“CODM”). The CODM reviews discrete financial information for the operating segments in order to assess their </span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">performance and is responsible for making decisions about resources allocated to the segments. The CODM has been identified as the Group’s Board of Directors.</span></div> <div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For presentation of the Consolidated Statement of Comprehensive Income/(Loss), the Group uses a classification based on the function of expenses, rather than based on their nature, as it is more representative of the format used for internal reporting and management purposes and is consistent with international practice.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Certain amounts in the Consolidated Financial Statements and accompanying notes may not add due to rounding. All percentages have been calculated using unrounded amounts.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Basis of Measurement </span></div>The Consolidated Financial Statements are prepared on the historical cost basis except that the following assets and liabilities are stated at their fair value: investments held at fair value, investments in notes from associates and liabilities classified as fair value through the profit or loss. <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Use of Judgments and Estimates </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In preparing the Consolidated Financial Statements, management has made judgements, estimates and assumptions that affect the application of the Group’s accounting policies and the reported amounts of assets, liabilities, income and expenses. Actual results may differ from these estimates. Estimates and underlying assumptions are reviewed on an on-going basis.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Significant estimation is applied in determining the following:</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Financial instruments valuations (see Note 18. Financial Instruments): In accordance with IFRS 9, the Group carries certain financial assets and financial liabilities at fair value, with changes in fair value through profit and loss ("FVTPL"). Valuation of the aforementioned financial instruments (assets and liabilities) includes making significant estimates, specifically determining the appropriate valuation methodology and making certain estimates such as the future expected returns on the financial instrument in different scenarios, appropriate discount rate, volatility, and term to exit. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Significant judgement is also applied in determining the following:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Whether financial instruments should be classified as liability or equity (see Note 16. Subsidiary Preferred Shares.). The judgement includes an assessment of whether the financial instruments include contractual obligations of the Group to deliver cash or other financial assets or to exchange financial assets or financial liabilities with another party, and whether those obligations could be settled by the Group exchanging a fixed amount of cash or other financial assets for a fixed number of its own equity instruments. Further information about these critical judgements and estimates is included below under Financial Instruments.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Whether the power to control investees exists (see Note 5. Investments Held at Fair Value and Note 6. Investments in Associates and accounting policy with regard to Subsidiaries below). The judgement includes an assessment of whether the Group has (i) power over the investee; (ii) exposure, or rights, to variable returns from its involvement with the investee; and (iii) the ability to use its power over the investee to affect the amount of its own returns. The Group considers among others its voting shares, shareholder agreements, ability to appoint board members, representation on the board, rights to appoint management, de facto control, investee dependence on the Group, etc. If the power to control the investee exists, it consolidates the financial statements of such investee in the Consolidated Financial Statements of the Group. Upon issuance of new shares in an investee and/or a change in any shareholders or governance agreements, the Group reassesses its ability to control the investee based on the revised voting interest, revised board composition and revised subsidiary governance and management structure. When such new circumstances result in the Group losing its power to control the investee, the investee is deconsolidated. On March 1 2023 Vedanta was deconsolidated. Although the Group holds 47% of the voting rights and the other shareholders are widely dispersed, the Group does not have de facto control because the investor rights agreement stipulates that the relevant activities of Vedanta are directed by Vedanta's Board and the Group does not control Vedanta's Board decision making. Voting rights are not the dominant factor for directing Vedanta's relevant activities.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Whether the Group has significant influence over financial and operating policies of investees in order to determine if the Group should account for its investment as an associate based on IAS 28 or a financial instrument based on IFRS 9. (refer to Note 5. Investments Held at Fair Value and Note 6. Investments in Associates ). This judgement includes, among others, an assessment whether the Group has representation on the board of directors of the investee, whether the Group participates in the policy making processes of the investee, whether there is any interchange of managerial personnel, whether there is any essential technical information provided to the investee and if there are any transactions between the Group and the investee.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Upon determining that the Group does have significant influence over the financial and operating policies of an investee, if the Group holds more than a single instrument issued by its equity-accounted investee, judgement is required to determine whether the additional instrument forms part of the investment in the associate, which is accounted for under IAS 28 and </span></div><div style="padding-left:11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">scoped out of IFRS 9, or it is a separate financial instrument that falls in the scope of IFRS 9. This judgement includes an assessment of the characteristics of the financial instrument of the investee held by the Group and whether such financial instrument provides access to returns underlying an ownership interest.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">When the Group has other investments in an equity accounted investee that are not accounted for under IAS 28, judgement is required in determining if such investments constitute long-term interests ("LTI") for the purposes of IAS 28. This determination is based on the individual facts and circumstances and characteristics of each investment, but is driven, among other factors, by the intention and likelihood to settle the instrument through redemption or repayment in the foreseeable future, and whether or not the investment is likely to be converted to common stock or other equity instruments. After considering the individual facts and circumstances of the Group’s investment in its associate's preferred stock in the manner described above, including the long-term nature of such investment, the ability of the Group to convert its preferred stock investment to an investment in common shares and the likelihood of such conversion, the Group concluded that such investment was considered a long term interest.</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">In determining the appropriate accounting treatment for the Royalty Purchase Agreement, management applied significant judgement (refer to Note 17. Sale of Future Royalties Liability).</span></div> 0.47 191081000 136062000 Considering the Group’s financial position as of December 31, 2023, and its principal risks and opportunities, the Group prepared a going concern analysis covering a period of at least the twelve-month period from the date of signing the Consolidated Financial Statements ("the going concern period") utilizing realistic scenarios and applying a severe but plausible downside scenario. Even under the downside scenario, the analysis demonstrates the Group continues to maintain sufficient liquidity headroom and continues to comply with all financial obligations. The Board of Directors believe the Group and the Parent is adequately resourced to continue in operational existence for at least the twelve-month period from the date of signing the Consolidated Financial Statements. Accordingly, the Board of Directors considered it appropriate to adopt the going concern basis of accounting in preparing the Consolidated Financial Statements and the PureTech Health plc Financial Statements. <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Basis of consolidation</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Consolidated Financial Statements as of December 31, 2023 and 2022, and for each of the years ended December 31, 2023, 2022 and 2021, comprises PureTech Health plc and its consolidated subsidiaries. Intra-group balances and transactions, and any unrealized income and expenses arising from intra-group transactions, are eliminated.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiaries </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As used in these financial statements, the term subsidiaries refers to entities that are controlled by the Group. Under applicable accounting rules, the Group controls an entity when it is exposed to, or has the rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its power over the entity. In assessing control, the Group takes into consideration potential voting rights, board representation, shareholders' agreements, ability to appoint board of directors and management, de facto control and other related factors. The financial statements of subsidiaries are included in the Consolidated Financial Statements from the date that control commences until the date that control ceases. Losses applicable to the non-controlling interests in a subsidiary are allocated to the non-controlling interests even if doing so causes the non-controlling interests to have a deficit balance.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in Subsidiary Ownership and Loss of Control </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the Group’s interest in a subsidiary that do not result in a loss of control are accounted for as equity transactions.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Where the Group loses control of a subsidiary, the assets and liabilities are derecognized along with any related non-controlling interest (“NCI”). Any interest retained in the former subsidiary is measured at fair value when control is lost. Any resulting gain or loss is recognized as profit or loss in the Consolidated Statement of Comprehensive Income/(Loss).</span></div> All current subsidiaries are domiciled within the United States and conduct business activities solely within the United States. <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:43.142%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.990%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:7.996%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="24" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Voting percentage at December 31, through the holdings in</span></div></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Subsidiary</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Common</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"><span style="font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%"> Preferred</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Common</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"><span style="font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%"> Preferred</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Common</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"><span style="font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%"> Preferred</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Subsidiary operating companies</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Alivio Therapeutics, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega, Inc. (indirectly held through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">77.3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">77.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">77.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech LYT, Inc. (formerly Ariya Therapeutics, Inc.)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech LYT 100, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Management, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">3</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Health LLC</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">3</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Deconsolidated former subsidiary operating companies</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sonde Health, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2,5</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">40.2</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">40.2 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">51.8 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Akili Interactive Labs, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2,6</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">14.6</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1,2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22.8 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4.8 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">19.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Karuna Therapeutics, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2,6</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.1 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5.6 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2, 4</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48.6 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences Securities Corp. (indirectly held through Vedanta)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2, 4</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48.6 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vor Biopharma Inc</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">.2,6</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3.9</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4.1 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.6 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Nontrading holding companies</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:justify"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.4pt;font-weight:400;line-height:120%">Endra Holdings, LLC (held indirectly through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.46pt;font-weight:400;line-height:120%;position:relative;top:-2.94pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">86.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:justify"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.4pt;font-weight:400;line-height:120%">Ensof Holdings, LLC (held indirectly through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.46pt;font-weight:400;line-height:120%;position:relative;top:-2.94pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">86.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Securities Corp.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PureTech Securities II Corp.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Inactive subsidiaries</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Appeering, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Commense Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">99.1</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">99.1 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">99.1 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Enlight Biosciences, LLC</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">86.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8pt;font-weight:400;line-height:120%">Ensof Biosystems, Inc. (held indirectly through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.2pt;font-weight:400;line-height:120%;position:relative;top:-2.8pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">57.7</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">28.3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica, LLC </span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">28.7</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">56.7</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">56.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">56.7 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Knode Inc. (indirectly held through Enlight)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">86.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Libra Biosciences, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Mandara Sciences, LLC</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">98.3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">98.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">98.3 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tal Medical, Inc.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">100.0</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100.0 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    On October 30, 2023, Gelesis ceased operations and filed a voluntary petition for relief under the United States bankruptcy code. See Note 6. Investments in Associates for details.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Registered address is Corporation Trust Center, 1209 Orange St., Wilmington, DE 19801, USA.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">3    Registered address is 2711 Centerville Rd., Suite 400, Wilmington, DE 19808, USA.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">4    On March 1, 2023, the Group lost control over Vedanta and Vedanta was deconsolidated from the Group’s financial statements, resulting in only the profits and losses generated by Vedanta through the deconsolidation date being included in the Group’s Consolidated Statement of Comprehensive Income/(Loss). See Notes 5. Investments Held at Fair Value for further details about the accounting for the investments in Vedanta subsequent to deconsolidation.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">5    On May 25, 2022, the Group lost control over Sonde and Sonde was deconsolidated from the Group’s financial statements, resulting in only the profits and losses generated by Sonde through the deconsolidation date being included in the Group’s Consolidated Statement of Comprehensive Income/(Loss). See Notes 5. Investments Held at Fair Value and 6. Investments in Associates for further details about the accounting for the investments in Sonde subsequent to deconsolidation.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">6    See Notes 5. Investments Held at Fair Value and 6. Investments in Associates for additional discussion on the Group's investment held in Akili, Karuna and Vor.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">7    Follica became inactive during 2023.</span></div> 0 1.000 0 1.000 0 1.000 0 0.773 0 0.773 0 0.773 0 1.000 0 1.000 0 1.000 0 1.000 0 1.000 0 1.000 1.000 0 1.000 0 1.000 0 1.000 0 1.000 0 1.000 0 0 0.402 0 0.402 0 0.518 0.146 0 0.147 0 0 0.267 0 0 0.228 0 0.048 0.197 0.023 0 0.031 0 0.056 0 0 0.470 0 0.470 0 0.486 0 0.470 0 0.470 0 0.486 0.039 0 0.041 0 0.086 0 0.860 0 0.860 0 0.860 0 0.860 0 0.860 0 0.860 0 1.000 0 1.000 0 1.000 0 1.000 0 1.000 0 1.000 0 0 1.000 0 1.000 0 1.000 0 0.991 0 0.991 0 0.991 0.860 0 0.860 0 0.860 0 0.577 0.283 0.577 0.283 0.577 0.283 0.287 0.567 0.287 0.567 0.287 0.567 0 0.860 0 0.860 0 0.860 0 1.000 0 1.000 0 1.000 0.983 0 0.983 0 0.983 0 0 1.000 0 1.000 0 1.000 <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Associates </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As used in these financial statements, the term associates are those entities in which the Group has no control but maintains significant influence over the financial and operating policies. Significant influence is presumed to exist when the Group holds between 20 and 50 percent of the voting power of an entity, unless it can be clearly demonstrated that this is not the case. The Group evaluates if it maintains significant influence over associates by assessing if the Group has the power to participate in the financial and operating policy decisions of the associate.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Application of the Equity Method to Associates </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Associates are accounted for using the equity method (equity accounted investees) and are initially recognized at cost, or if recognized upon deconsolidation, they are initially recorded at fair value at the date of deconsolidation. The Consolidated </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial Statements include the Group’s share of the total comprehensive income or loss of equity accounted investees, from the date that significant influence commences until the date that significant influence ceases. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">To the extent the Group holds interests in associates that are not providing access to returns underlying ownership interests, the instrument is accounted for in accordance with IFRS 9 as investments held at fair value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">When the Group’s share of losses exceeds its equity method investment in the investee, losses are applied against long-term interests, which are investments accounted for under IFRS 9. Investments are determined to be long-term interests when they are long-term in nature and in substance they form part of the Group's net investment in that associate. This determination is impacted by many factors, among others, whether settlement by the investee through redemption or repayment is planned or likely in the foreseeable future, whether the investment can be converted and/or is likely to be converted to common stock or other equity instrument and other factors regarding the nature of the investment. Whilst this assessment is dependent on many specific facts and circumstances of each investment, typically conversion features whereby the investment is likely to convert to common stock or other equity instruments would point to the investment being a long-term interest. Similarly, where the investment is not planned or likely to be settled through redemption or repayment in the foreseeable future, this would indicate that the investment is a long-term interest. When the net investment in the associate, which includes the Group’s investments in other long-term interests, is reduced to nil, recognition of further losses is discontinued except to the extent that the Group has incurred legal or constructive obligations or made payments on behalf of an investee.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has adopted the amendments to IAS 28 Investments in Associates that addresses the dual application of IAS 28 and IFRS 9 when equity method losses are applied against long-term interests. The amendments provide the annual sequence in which both standards are to be applied in such a case. The Group has applied the equity method losses to the long-term interests presented as part of Investments held at fair value subsequent to remeasuring such investments to their fair value at balance sheet date.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sale of Future Royalties Liability</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group accounts for the sale of future royalties liability as a financial liability, as it continues to hold the rights under the royalty bearing licensing agreement and has a contractual obligation to deliver cash to an investor for a portion of the royalty it receives. Interest on the sale of future royalties liability is recognized using the effective interest rate over the life of the related royalty stream.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The sale of future royalties liability and the related interest expense are based on the Group’s current estimates of future royalties expected to be paid over the life of the arrangement. Forecasts are updated periodically as new data is obtained. Any increases, decreases or a shift in timing of estimated cash flows require the Group to re-calculate the amortized cost of the sale of future royalties liability as the present value of the estimated future contractual cash flows that are discounted at the liability’s original effective interest rate. The adjustment is recognized immediately in profit or loss as income or expense.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial Instruments </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Classification </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group classifies its financial assets in the following measurement categories:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Those to be measured subsequently at fair value either through other comprehensive income "FVOCI", or through profit or loss "FVTPL", and</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Those to be measured at amortized cost.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The classification depends on the Group’s business model for managing the financial assets and the contractual terms of the cash flows.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For assets measured at fair value, gains and losses are recorded in profit or loss. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Measurement </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">At initial recognition, the Group measures a financial asset at its fair value plus, in the case of a financial asset not at FVTPL, transaction costs that are directly attributable to the acquisition of the financial asset. Transaction costs of financial assets that are carried at FVTPL are expensed.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Impairment </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group assesses on a forward-looking basis the expected credit losses associated with its debt instruments carried at amortized cost. For trade receivables, the Group applies the simplified approach permitted by IFRS 9, which requires expected lifetime losses to be recognized from initial recognition of the receivables.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Financial Assets </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s financial assets consist of cash and cash equivalents, investments in debt securities, trade and other receivables, notes, restricted cash deposits and investments in equity securities. The Group’s financial assets are virtually all classified into the following categories: investments held at fair value, notes, trade and other receivables, short-term investments and cash and cash equivalents. The Group determines the classification of financial assets at initial recognition depending on the purpose for which the financial assets were acquired.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value are investments in equity instruments. Such investments consist of the Group's minority interest holdings where the Group has no significant influence or preferred share investments that are not providing access to returns underlying ownership interests and are categorized as debt instruments that are presented at fair value through profit and loss because the amounts receivable do not represent solely payments of principal and interest. These financial assets are initially measured at fair value and subsequently re-measured at fair value at each reporting date. The Group has elected to record the changes in fair values for the financial assets falling under this category through profit and loss. Please refer to Note 5. Investments Held at Fair Value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the fair value of financial assets at FVTPL are recognized in other income/(expense) in the Consolidated Statement of Comprehensive Income/(Loss) as applicable. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The notes from an associate, since their contractual terms do not consist solely of cash flow payments of principal and interest on the principal amount outstanding, are initially and subsequently measured at fair value, with changes in fair value recognized through profit and loss.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash and cash equivalents consist of demand deposits with banks and other financial institutions and highly liquid instruments with original maturities of three months or less at the date of purchase. Cash and cash equivalents are carried at cost, which approximates their fair value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term investments consist of short-term US treasury bills that are held to maturity. The contractual terms consist solely of payment of the principal and interest and the Group's business model is to hold the treasury bills to maturity. As such, such short-term investments are recorded at amortized cost. As of balance sheet date, amortized cost approximated the fair value of such short-term investments.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other receivables are non-derivative financial assets with fixed and determinable payments that are not quoted on active markets. These financial assets are carried at the amounts expected to be received less any expected lifetime losses. Such losses are determined taking into account previous experience, credit rating and economic stability of counterparty and economic conditions. When a trade receivable is determined to be uncollectible, it is written off against the available provision. As of balance sheet date, the Group did not record any such expected lifetime losses related to the outstanding trade and other receivable balances. Trade and other receivables are included in current assets, unless maturities are greater than 12 months after the end of the reporting period.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Financial Liabilities </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s financial liabilities primarily consist of trade and other payables, and preferred shares. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The majority of the Group’s subsidiaries have preferred shares and certain notes payable with embedded derivatives, which are classified as current liabilities. When the Group has preferred shares and notes with embedded derivatives that qualify for bifurcation, the Group has elected to account for the entire instrument as FVTPL after determining under IFRS 9 that the instrument qualifies to be accounted for under such FVTPL method.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group derecognizes a financial liability when its contractual obligations are discharged, cancelled or expire.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity Instruments Issued by the Group </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial instruments issued by the Group are treated as equity only to the extent that they meet the following two conditions, in accordance with IAS 32:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:4.26pt">They include no contractual obligations upon the Group to deliver cash or other financial assets or to exchange financial assets or financial liabilities with another party under conditions that are potentially unfavorable to the Group; and</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:4.26pt">Where the instrument will or may be settled in the Group’s own equity instruments, it is either a non-derivative that includes no obligation to deliver a variable number of the Group’s own equity instruments or is a derivative that will be settled by the Group exchanging a fixed amount of cash or other financial assets for a fixed number of its own equity instruments.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">To the extent that this definition is not met, the financial instrument is classified as a financial liability. Where the instrument so classified takes the legal form of the Group’s own shares, the amounts presented in the Group's shareholders' equity exclude amounts in relation to those shares.</span></div>Changes in the fair value of liabilities at FVTPL are recognized in net finance income /(costs) in the Consolidated Statement of Comprehensive Income/(Loss) as applicable. <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">IFRS 15, Revenue from Contracts with Customers </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The standard establishes a five-step principle-based approach for revenue recognition and is based on the concept of recognizing an amount that reflects the consideration for performance obligations only when they are satisfied and the control of goods or services is transferred.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The majority of the Group’s contract revenue is generated from licenses and services, some of which are part of collaboration arrangements. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Management reviewed contracts where the Group received consideration in order to determine whether or not they should be accounted for in accordance with IFRS 15. To date, the Group has entered into transactions that generate revenue and meet the scope of either IFRS 15 or IAS 20 Accounting for Government Grants. Contract revenue is recognized at either a point-in-time or over time, depending on the nature of the performance obligations.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group accounts for agreements that meet the definition of IFRS 15 by applying the following five step model:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Identify the contract(s) with a customer – A contract with a customer exists when (i) the Group enters into an enforceable contract with a customer that defines each party’s rights regarding the goods or services to be transferred and identifies the payment terms related to those goods or services, (ii) the contract has commercial substance and, (iii) the Group determines that collection of substantially all consideration for goods or services that are transferred is probable based on the customer’s intent and ability to pay the promised consideration.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Identify the performance obligations in the contract – Performance obligations promised in a contract are identified based on the goods or services that will be transferred to the customer that are both capable of being distinct, whereby the customer can benefit from the good or service either on its own or together with other resources that are readily available from third parties or from the Group, and are distinct in the context of the contract, whereby the transfer of the goods or services is separately identifiable from other promises in the contract.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Determine the transaction price – The transaction price is determined based on the consideration to which the Group will be entitled in exchange for transferring goods or services to the customer. To the extent the transaction price includes variable consideration, the Group estimates the amount of variable consideration that should be included in the transaction price utilizing either the expected value method or the most likely amount method depending on the nature of the variable consideration. Variable consideration is included in the transaction price if, in the Group’s judgement, it is probable that a significant future reversal of cumulative revenue under the contract will not occur. </span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Allocate the transaction price to the performance obligations in the contract – If the contract contains a single performance obligation, the entire transaction price is allocated to the single performance obligation. Contracts that contain multiple performance obligations require an allocation of the transaction price to each performance obligation based on a relative standalone selling price basis. </span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Recognize revenue when (or as) the Group satisfies a performance obligation – The Group satisfies performance obligations either over time or at a point in time as discussed in further detail below. Revenue is recognized at the time the related performance obligation is satisfied by transferring a promised good or service to a customer.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revenue generated from services agreements (typically where licenses and related services were combined into one performance obligation) is determined to be recognized over time when it can be determined that the services meet one of the following: (a) the customer simultaneously receives and consumes the benefits provided by the entity’s performance as the entity performs; (b) the entity’s performance creates or enhances an asset that the customer controls as the asset is created or enhanced; or (c) the entity’s performance does not create an asset with an alternative use to the entity and the entity has an enforceable right to payment for performance completed to date.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">It was determined that the Group has contracts that meet criteria (a), since the customer simultaneously receives and consumes the benefits provided by the Group’s performance as the Group performs. Therefore revenue is recognized over time using the input method based on costs incurred to date as compared to total contract costs. The Group believes that in research and development service type agreements using costs incurred to date represents the most faithful depiction of the entity’s performance towards complete satisfaction of a performance obligation.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revenue from licenses that are not part of a combined performance obligation are recognized at a point in time due to the licenses relating to intellectual property that has significant stand-alone functionality and as such represent a right to use the entity's intellectual property as it exists at the point in time at which the license is granted.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Royalty income received in respect of licensing agreements when the license of intellectual property is the predominant item in the arrangement is recognized as the related third-party sales in the licensee occur.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amounts that are receivable or have been received per contractual terms but have not been recognized as revenue since performance has not yet occurred or has not yet been completed are recorded as deferred revenue. The Group classifies as non-current deferred revenue amounts received for which performance is expected to occur beyond one year or one operating cycle.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Grant Revenue</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group recognizes grants from governmental agencies as grant revenue in the Consolidated Statement of Comprehensive Income/(Loss), gross of the expenditures that were related to obtaining the grant, when there is reasonable assurance that the Group will comply with the conditions within the grant agreement and there is reasonable assurance that payments under the grants will be received. The Group evaluates the conditions of each grant as of each reporting date to ensure that the Group has reasonable assurance of meeting the conditions of each grant arrangement and that it is expected that the grant payment will be received as a result of meeting the necessary conditions.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group submits qualifying expenses for reimbursement after the Group has incurred the research and development expense. The Group records an unbilled receivable upon incurring such expenses. In cases in which the grant revenue is received prior to the expenses being incurred or recognized, the amounts received are deferred until the related expense is incurred and/or recognized. Grant revenue is recognized in the Consolidated Statement of Comprehensive Income/(Loss) at the time in which the Group recognizes the related reimbursable expense for which the grant is intended to compensate.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Functional and Presentation Currency </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Consolidated Financial Statements are presented in United States dollars (“US dollars”). The functional currency of all members of the Group is the U.S. dollar. The Group's share in foreign exchange differences in associates were reported in other comprehensive income/(loss).</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Foreign Currency </span></div>Transactions in foreign currencies are translated to the respective functional currencies of Group entities at the foreign exchange rate ruling at the date of the transaction. Monetary assets and liabilities denominated in foreign currencies at the balance sheet date are retranslated to the functional currency at the foreign exchange rate ruling at that date. Foreign exchange differences arising on remeasurement are recognized in the Consolidated Statement of Comprehensive Income/(Loss). Non-monetary assets and liabilities that are measured in terms of historical cost in a foreign currency are translated using the exchange rate at the date of the transaction. <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share Capital </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Ordinary shares are classified as equity. The Group's equity is comprised of share capital, share premium, merger reserve, other reserve, translation reserve, and retained earnings/accumulated deficit.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Treasury Shares</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Treasury shares are recognized at cost and are deducted from shareholders' equity. No gain or loss is recognized in profit and loss for the purchase, sale, re-issue or cancellation of the Group's own equity shares.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Property and Equipment </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Property and equipment is stated at cost less accumulated depreciation and any accumulated impairment losses. Cost includes expenditures that are directly attributable to the acquisition of the asset. Assets under construction represent leasehold improvements and machinery and equipment to be used in operations or research and development activities. When parts of an item of property and equipment have different useful lives, they are accounted for as separate items (major components) of property and equipment. Depreciation is calculated using the straight-line method over the estimated useful life of the related asset: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:47.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:50.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Laboratory and manufacturing equipment</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2-8 years</span></div></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Furniture and fixtures</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7 years</span></div></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Computer equipment and software</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1-5 years</span></div></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Leasehold improvements</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5-10 years, or the remaining term of the lease, if shorter</span></div></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation methods, useful lives and residual values are reviewed at each balance sheet date.</span></div> Depreciation is calculated using the straight-line method over the estimated useful life of the related asset: <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:47.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:50.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Laboratory and manufacturing equipment</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2-8 years</span></div></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Furniture and fixtures</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7 years</span></div></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Computer equipment and software</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1-5 years</span></div></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Leasehold improvements</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5-10 years, or the remaining term of the lease, if shorter</span></div></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation methods, useful lives and residual values are reviewed at each balance sheet date.</span></div> P2Y P8Y P7Y P1Y P5Y P5Y P10Y <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Intangible Assets </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Intangible assets, which include purchased patents and licenses with finite useful lives, are carried at historical cost less accumulated amortization, if amortization has commenced. Intangible assets with finite lives are amortized from the time they are available for their intended use. Amortization is calculated using the straight-line method to allocate the costs of patents and licenses over their estimated useful lives. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development intangible assets, which are still under development and have accordingly not yet obtained marketing approval, are presented as In-Process Research and Development (IPR&amp;D). The cost of IPR&amp;D represents upfront payments as well as additional contingent payments based on development, regulatory and sales milestones related to certain license agreement where the Group licenses IP from a third party. These milestones are capitalized as the milestone is triggered. See Note 25. Commitments and Contingencies. IPR&amp;D is not amortized since it is not yet available for its intended use, but it is evaluated for potential impairment on an annual basis or more frequently when facts and circumstances warrant.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment of Non-Financial Assets </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group reviews the carrying amounts of its property and equipment and intangible assets at each reporting date to determine whether there are indicators of impairment. If any such indicators of impairment exist, then an asset’s recoverable amount is estimated. The recoverable amount is the higher of an asset’s fair value less cost of disposal and value in use.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s IPR&amp;D intangible assets are not yet available for their intended use. As such, they are tested for impairment at least annually. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">An impairment loss is recognized when an asset’s carrying amount exceeds its recoverable amount. For the purposes of impairment testing, assets are grouped at the lowest levels for which there are largely independent cash flows. If a non- financial asset instrument is impaired, an impairment loss is recognized in the Consolidated Statement of Comprehensive Income/(Loss).</span></div>Investments in associates are considered impaired if, and only if, objective evidence indicates that one or more events, which occurred after the initial recognition, have had an impact on the future cash flows from the net investment and that impact can be reliably estimated. If an impairment exists, the Group measures an impairment by comparing the carrying value of the net investment in the associate to its recoverable amount and recording any excess as an impairment loss. <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Employee Benefits </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Short-Term Employee Benefits </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term employee benefit obligations are measured on an undiscounted basis and expensed as the related service is provided. A liability is recognized for the amount expected to be paid if the Group has a present legal or constructive obligation due to past service provided by the employee, and the obligation can be estimated reliably.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Defined Contribution Plans </span></div>A defined contribution plan is a post-employment benefit plan under which an entity pays fixed contributions into a separate entity and has no legal or constructive obligation to pay further amounts. Obligations for contributions to defined contribution plans are recognized as an employee benefit expense in the periods during which related services are rendered by employees. <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Share-based Payments </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payment arrangements, in which the Group receives goods or services as consideration for its own equity instruments, are accounted for as equity-settled share-based payment transactions (except certain restricted stock units - see below) in accordance with IFRS 2, regardless of how the equity instruments are obtained by the Group. The grant date fair value of employee share-based payment awards is recognized as an expense with a corresponding increase in equity over the requisite service period related to the awards. The amount recognized as an expense is adjusted to reflect the actual number of awards for which the related service and non-market performance conditions are expected to be met, such that the amount ultimately recognized as an expense is based on the number of awards that do meet the related service and non-market performance conditions at the vesting date. For share-based payment awards with market conditions, the grant date fair value is measured to reflect such conditions and there is no true-up for differences between expected and actual outcomes.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Certain restricted stock units are treated as liability settled awards starting in 2021. Such awards are remeasured at every reporting date until settlement date and are recognized as compensation expense over the requisite service period. Differences in remeasurement are recognized in profit and loss. The cumulative cost that will ultimately be recognized in respect of these awards will equal to the amount at settlement. </span></div>The fair value of the awards is measured using option pricing models and other appropriate models, which take into account the terms and conditions of the awards granted. <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Development Costs </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Expenditures on research activities are recognized as incurred in the Consolidated Statement of Comprehensive Income/(Loss). In accordance with IAS 38, development costs are capitalized only if the expenditure can be measured reliably, the product or process is technically and commercially feasible, future economic benefits are probable, the Group can demonstrate its ability to use or sell the intangible asset, the Group intends to and has sufficient resources to complete development and to use or sell the asset, and it is able to measure reliably the expenditure attributable to the intangible asset during its development. The point at which technical feasibility is determined to have been reached is, generally, when regulatory approval has been received where applicable. Management determines that commercial viability has been reached when a clear market and pricing point have been identified, which may coincide with achieving meaningful recurring sales. Otherwise, the development expenditure is recognized </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">as incurred in the Consolidated Statement of Comprehensive Income/(Loss). As of balance sheet date, the Group has not capitalized any development costs.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Provisions </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">A provision is recognized in the Consolidated Statement of Financial Position when the Group has a present legal or constructive obligation due to a past event that can be reliably measured, and it is probable that an outflow of economic benefits will be required to settle the obligation. Provisions are determined by discounting the expected future cash flows at a pre-tax rate that reflects risks specific to the liability.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Leases</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group leases real estate for use in operations. These leases have lease terms of approximately 10 years. The Group includes options that are reasonably certain to be exercised as part of the determination of the lease term. The group determines if an arrangement is a lease at inception of the contract in accordance with guidance detailed in IFRS 16. Right-of-use (ROU) assets represent the Group’s right to use an underlying asset for the lease term and lease liabilities represent the Group's obligation to make lease payments arising from the lease. Operating lease ROU assets and lease liabilities are recognized at commencement date based on the present value of the lease payments over the lease term. As most of the Group's leases do not provide an implicit rate, the Group used its estimated incremental borrowing rate, based on information available at commencement date, in determining the present value of future payments. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s leases are virtually all leases of real estate.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has elected to account for lease payments as an expense on a straight-line basis over the life of the lease for: </span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Leases with a term of 12 months or less and containing no purchase options; and </span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Leases where the underlying asset has a value of less than $5,000. </span></div>The right-of-use asset is depreciated on a straight-line basis and the lease liability gives rise to an interest charge. P10Y <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Finance Income and Finance Costs </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Finance income consists of interest income on funds invested in money market funds and U.S. treasuries. Finance income is recognized as it is earned. Finance costs consist mainly of loan, notes and lease liability interest expenses, interest expense due to accretion of and adjustment to sale of future royalties liability as well as the changes in the fair value of financial liabilities carried at FVTPL (such changes can consist of finance income when the fair value of such financial liabilities decreases).</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Taxation </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax on the profit or loss for the year comprises current and deferred income tax. In accordance with IAS 12, tax is recognized in the Consolidated Statement of Comprehensive Income/(Loss) except to the extent that it relates to items recognized directly in equity.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Current income tax is the expected tax payable or receivable on the taxable income or loss for the year, using tax rates enacted or substantially enacted at the reporting date, and any adjustment to tax payable in respect of previous years.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax is recognized due to temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for taxation purposes. Deferred tax assets are recognized for unused tax losses, unused tax credits and deductible temporary differences to the extent that it is probable that future taxable profits will be available against which they can be used. Deferred tax assets with respect to investments in associates are recognized only to the extent that it is probable the temporary difference will reverse in the foreseeable future and taxable profit will be available against which the temporary difference can be utilized. Deferred tax assets are reviewed at each reporting date and are reduced to the extent that it is no longer probable that the related tax benefit will be realized.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax is measured at the tax rates that are expected to be applied to temporary differences when they reverse, using tax rates enacted or substantively enacted at the reporting date.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred income tax assets and liabilities are offset when there is a legally enforceable right to offset current tax assets against current tax liabilities and when the deferred income tax assets and liabilities relate to income taxes levied by the same taxation authority on either the same taxable entity or different taxable entities where there is an intention to settle the balances on a net basis.</span></div> <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Fair Value Measurements </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s accounting policies require that certain financial assets and certain financial liabilities be measured at their fair value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group uses valuation techniques that are appropriate in the circumstances and for which sufficient data are available to measure fair value, maximizing the use of relevant observable inputs and minimizing the use of unobservable inputs. Fair values are categorized into different levels in a fair value hierarchy based on the inputs used in the valuation techniques as follows:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Level 1: quoted prices (unadjusted) in active markets for identical assets or liabilities.</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Level 2: inputs other than quoted prices included in Level 1 that are observable for the asset or liability, either directly (i.e. as prices) or indirectly (i.e. derived from prices).</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">Level 3: inputs for the asset or liability that are not based on observable market data (unobservable inputs).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group recognizes transfers between levels of the fair value hierarchy at the end of the reporting period during which the change has occurred.</span></div>The carrying amount of cash and cash equivalents, accounts receivable, restricted cash, deposits, accounts payable, accrued expenses and other current liabilities in the Group’s Consolidated Statement of Financial Position approximates their fair value because of the short maturities of these instruments. <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating Segments </span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating segments are reported in a manner that is consistent with the internal reporting provided to the chief operating decision maker (“CODM”). The CODM reviews discrete financial information for the operating segments in order to assess their </span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">performance and is responsible for making decisions about resources allocated to the segments. The CODM has been identified as the Group’s Board of Directors.</span></div> New Standards and Interpretations<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has applied the following amendments for the first time for its annual reporting period commencing January 1, 2023:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">IFRS 17 </span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Insurance Contracts</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%;padding-left:7.09pt">Definition of Accounting Estimates</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> (Amendments to IAS 8)</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%;padding-left:7.09pt">Deferred Tax related to Assets and Liabilities Arising from a Single Transaction</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> (Amendments to IAS 12)</span></div><div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The amendments listed above did not have any impact on the amounts recognized in prior and current periods and are not expected to significantly affect the future periods.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Certain new accounting standards, amendments to accounting standards and interpretations have been published that are not mandatory for December 31, 2023 reporting periods and have not been early adopted by the Group. These standards, amendments or interpretations are not expected to have a material impact on the Group in the current or future reporting periods and on foreseeable future transactions.</span></div> New Standards and Interpretations<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has applied the following amendments for the first time for its annual reporting period commencing January 1, 2023:</span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%;padding-left:7.09pt">IFRS 17 </span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Insurance Contracts</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></div><div style="padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%;padding-left:7.09pt">Definition of Accounting Estimates</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> (Amendments to IAS 8)</span></div><div style="margin-bottom:5pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">•</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%;padding-left:7.09pt">Deferred Tax related to Assets and Liabilities Arising from a Single Transaction</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> (Amendments to IAS 12)</span></div><div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The amendments listed above did not have any impact on the amounts recognized in prior and current periods and are not expected to significantly affect the future periods.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Certain new accounting standards, amendments to accounting standards and interpretations have been published that are not mandatory for December 31, 2023 reporting periods and have not been early adopted by the Group. These standards, amendments or interpretations are not expected to have a material impact on the Group in the current or future reporting periods and on foreseeable future transactions.</span></div> Revenue <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revenue recorded in the Consolidated Statement of Comprehensive Income/(Loss) consists of the following:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ended December 31,</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contract revenue</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,090 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,979 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Grant revenue</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,580</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,528 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,409 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total revenue</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,330</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,618 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">17,388 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">All amounts recorded in contract revenue were generated in the United States. </span></div><div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For the years ended December 31, 2023, 2022 and 2021, contract revenue includes royalties received from an associate in the amounts of zero, $509 and $231, respectively.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Substantially all of the Group’s contracts related to contract revenue for the years ended December 31, 2023, 2022 and 2021 were determined to have a single performance obligation which consists of a combined deliverable of license of intellectual property and research and development services. Therefore, for such contracts, revenue is recognized over time based on the input method which the Group believes is a faithful depiction of the transfer of goods and services. Progress is measured based on costs incurred to date as compared to total projected costs. Payments for such contracts are primarily made up-front on a periodic basis.</span></div><div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2021, the Group received a $6,500 payment from Imbrium Therapeutics, Inc. following the exercise of the option to acquire an exclusive license for the Initial Product Candidate, as defined in the agreement. Since the license transferred was a right to use license, revenue from the option exercise was recognized at a point in time upon transfer of the license, which occurred during the year ended December 31, 2021.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disaggregated Revenue</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group disaggregates contract revenue in a manner that depicts how the nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factors. The Group disaggregates revenue based on contract revenue or grant revenue, and further disaggregates contract revenue based on the transfer of control of the underlying performance obligations.</span></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Timing of contract revenue recognition</span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ended December 31,</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Transferred at a point in time – Licensing Income</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">527 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,809 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Transferred over time</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,563 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,171 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"><div style="margin-bottom:10pt"><span><br/></span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,090 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,979 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:13.5pt;text-indent:-13.5pt"><span><br/></span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Customers over 10% of revenue</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Customer A</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Customer B</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,250 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Customer C</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">509 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,009 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,750 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div>Accounts receivables represent rights to consideration in exchange for products or services that have been transferred by the Group, when payment is unconditional and only the passage of time is required before payment is due. Accounts receivables do not bear interest and are recorded at the invoiced amount. Accounts receivables are included within trade and other receivables on the Consolidated Statement of Financial Position. The accounts receivables related to contract revenue were $555 and $606 as of December 31, 2023 and 2022, respectively. <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revenue recorded in the Consolidated Statement of Comprehensive Income/(Loss) consists of the following:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ended December 31,</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contract revenue</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,090 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,979 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Grant revenue</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,580</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,528 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,409 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total revenue</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,330</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,618 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">17,388 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 750000 2090000 9979000 2580000 13528000 7409000 3330000 15618000 17388000 0 509000 231000 6500000 <div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Timing of contract revenue recognition</span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ended December 31,</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Transferred at a point in time – Licensing Income</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">527 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,809 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Transferred over time</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,563 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,171 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"><div style="margin-bottom:10pt"><span><br/></span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,090 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,979 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:13.5pt;text-indent:-13.5pt"><span><br/></span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Customers over 10% of revenue</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Customer A</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Customer B</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,250 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Customer C</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">509 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,009 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,750 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 0 527000 6809000 750000 1563000 3171000 750000 2090000 9979000 750000 1500000 1500000 0 0 7250000 0 509000 0 750000 2009000 8750000 555000 606000 Segment Information<div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Basis for Segmentation </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Directors are the Group’s chief operating decision-makers. The Group’s operating segments are determined based on the financial information provided to the Board of Directors periodically for the purposes of allocating resources and assessing performance. During the second half of 2023, the Group changed the financial information that was regularly reviewed by the Board of Directors to allocate resources and assess performance. The Group has determined each of its Wholly-Owned Programs represents an operating segment and the Group has aggregated each of these operating segments into one reportable segment, the Wholly-Owned Programs segment, given the high level of operational and financial similarities across its Wholly-Owned Programs. Each of the Group’s Controlled Founded Entities represents an operating segment. The Group aggregates each Controlled Founded Entity operating segment into one reportable segment, the Controlled Founded Entities segment. For the Group’s entities that do not meet the definition of an operating segment, the Group presents this information in the Parent &amp; Other column in its segment footnote to reconcile the information in this footnote to the Consolidated Financial Statements. Substantially all of the Group’s revenue and profit generating activities are generated within the United States and, accordingly, no geographical disclosures are provided. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has retroactively recast its fiscal year 2022 and 2021 results on the new basis for comparability.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Following is the description of the Group's reportable segments:</span></div><div style="margin-top:5pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Wholly-Owned Programs</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Wholly-Owned Programs segment is advancing Wholly-Owned Programs which are focused on treatments for patients with devastating diseases. The Wholly-Owned Programs segment is comprised of the technologies that are wholly-owned and will be advanced through with either the Group's funding or non-dilutive sources of financing. The operational management of the Wholly-Owned Programs segment is conducted by the PureTech Health team, which is responsible for the strategy, business development, and research and development. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Controlled Founded Entities</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Controlled Founded Entities segment is comprised of the Group’s consolidated operational subsidiaries as of December 31, 2023 that either have, or have plans to hire, independent management teams and currently have already raised third-party dilutive capital. These subsidiaries have active research and development programs and either have entered into or plan to seek an equity or debt investment partner, who will provide additional industry knowledge and access to networks, as well as additional funding to continue the pursued growth of the entity. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s entities that were determined not to meet the definition of an operating segment are included in the Parent Company and Other column to reconcile the information in this footnote to the financial statements. This column captures activities not directly attributable to the Group's operating segments and includes the activities of the Parent, corporate support functions and certain research and development support functions that are not directly attributable to a strategic business segment as well as the elimination of intercompany transactions. This column also captures the operating results for the deconsolidated entities through the date of deconsolidation (e.g. Vedanta in 2023 and Sonde in 2022) and accounting for the Group's holdings in Founded Entities for which control has been lost, which primarily represents: the activity associated with deconsolidating an entity when the Group no longer controls the entity (e.g. Vedanta in 2023 and Sonde in 2022), the gain or loss on the Group's investments accounted for at fair value (e.g. the Group's ownership stakes in Karuna, Vor and Akili) and the Group's net income or loss of associates accounted for using the equity method. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(The term "Founded Entities" refers to entities which the Company incorporated and announced the incorporation as a Founded Entity externally. It includes certain of the Company’s wholly-owned subsidiaries which have been announced by the Company as Founded Entities, Controlled Founded Entities and deconsolidated Founded Entities.)</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In January 2024, the Group launched two new Founded Entities to advance certain programs from the Wholly-Owned Programs segment. Refer to Note 28. Subsequent Events for detail. The financial results of these programs were included in the Wholly-Owned Programs segment as of December 31, 2023 and 2022 and for the three years ended December 31, 2023, 2022 and 2021, respectively. Upon raising dilutive third-party financing, the financial results of these two entities will be included in the Controlled Founded Entities segment to the extent that the Group maintains control over these entities.</span></div><div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s Board of Directors reviews segment performance and allocates resources based upon revenue and operating loss as well as the funds available for each segment. The Board of Directors do not review any other information for purposes of assessing segment performance or allocating resources. </span></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="12" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">For the year ended December 31, 2023</span></div></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Wholly-Owned Programs</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Controlled Founded Entities</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Parent Company &amp; </span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Other</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Consolidated</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contract revenue</span></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Grant revenue</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">853</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,727</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,580</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total revenue</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">853</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,727</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,330</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative expenses</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(14,020)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(562)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(38,713)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(53,295)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(89,495)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(672)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(6,068)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(96,235)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total operating expense</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(103,516)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,233)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(44,781)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(149,530)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Operating income/(loss)</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(102,662)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(483)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(43,054)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(146,199)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/expenses not allocated to segments</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense):</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain on deconsolidation of subsidiary</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">61,787</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on investment held at fair value</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">77,945</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Realized loss on sale of investments</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(122)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on investment in notes from associates</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(27,630)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(908)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total other income/(expense)</span></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">111,072</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Net finance income/(costs)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,078</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share of net income/(loss) of associates accounted for using the equity method</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(6,055)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Income/(loss) before taxes</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(36,103)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="12" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">As of December 31, 2023</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Available Funds</span></div></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash and cash equivalents</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,140</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">675</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">188,266</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">191,081</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term Investments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">136,062</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">136,062</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Consolidated cash, cash equivalents and short-term investments</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,140</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">675</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">324,328</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">327,143</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:1pt;padding-left:11.34pt;text-indent:-11.34pt"><span><br/></span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="12" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31, 2022</span></div></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wholly-Owned Programs<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Controlled Founded Entities</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Parent</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Company &amp;</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Other</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Consolidated</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contract revenue</span></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">590 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,090 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Grant revenue</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,826 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,702 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,528 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total revenue</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,826 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,292 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,618 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative expenses</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,301)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(419)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(52,272)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(60,991)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(116,054)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,051)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(35,328)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(152,433)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total Operating expenses</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(124,355)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,470)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(87,600)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(213,425)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating income/(loss)</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(121,529)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">30 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(76,308)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(197,807)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/expenses not allocated to segments</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense):</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain on deconsolidation</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,251 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on investment held at fair value</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(32,060)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Realized loss on sale of investments</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(29,303)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,131 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total other income/(expense)</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(25,981)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Net finance income/(costs)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">138,924 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share of net income/(loss) of associate accounted for using the equity method</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(27,749)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain on dilution of ownership interest in associate</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28,220 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment of investment in associates</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,390)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/(loss) before taxes </span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,783)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="12" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31, 2022</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Available Funds</span></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash and cash equivalents</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,306 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">823 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">141,737 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149,866 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term Investments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Consolidated cash, cash equivalents and short-term investments</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,306 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">823 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">341,966 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">350,095 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="12" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31, 2021</span></div></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wholly-Owned Programs<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Controlled Founded Entities</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Parent</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Company &amp;</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Other</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Consolidated</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contract revenue</span></td><td colspan="2" style="border-top:0.5pt solid #6d6d6d;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,129 </span></td><td style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #6d6d6d;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.5pt solid #6d6d6d;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">350 </span></td><td style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #6d6d6d;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,979 </span></td><td style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Grant revenue</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,253 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,156 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,409 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total revenue</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,382 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,506 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">17,388 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative expenses</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,673)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(365)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(48,161)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(57,199)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(65,444)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(918)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(44,108)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(110,471)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total operating expense</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(74,118)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,284)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,269)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(167,671)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating income/(loss)</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(64,736)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">216 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(85,763)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(150,282)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/expenses not allocated to segments</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense):</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on investment held at fair value</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">179,316 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Realized loss on sale of investments</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(20,925)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,592 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense)</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">159,983 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Net finance income/(costs)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,050 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share of net income/(loss) of associate accounted for using the equity method</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(73,703)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/(loss) before taxes</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(58,953)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 1 1 2 2 <div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="12" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">For the year ended December 31, 2023</span></div></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Wholly-Owned Programs</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Controlled Founded Entities</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Parent Company &amp; </span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Other</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Consolidated</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contract revenue</span></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Grant revenue</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">853</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,727</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,580</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total revenue</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">853</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">750</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,727</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,330</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative expenses</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(14,020)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(562)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(38,713)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(53,295)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(89,495)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(672)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(6,068)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(96,235)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total operating expense</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(103,516)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,233)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(44,781)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(149,530)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Operating income/(loss)</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(102,662)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(483)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(43,054)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(146,199)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/expenses not allocated to segments</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense):</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain on deconsolidation of subsidiary</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">61,787</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on investment held at fair value</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">77,945</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Realized loss on sale of investments</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(122)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on investment in notes from associates</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(27,630)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(908)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total other income/(expense)</span></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">111,072</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Net finance income/(costs)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,078</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share of net income/(loss) of associates accounted for using the equity method</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(6,055)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Income/(loss) before taxes</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(36,103)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="12" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">As of December 31, 2023</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Available Funds</span></div></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash and cash equivalents</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,140</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">675</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">188,266</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">191,081</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term Investments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">136,062</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">136,062</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Consolidated cash, cash equivalents and short-term investments</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,140</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">675</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">324,328</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">327,143</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:1pt;padding-left:11.34pt;text-indent:-11.34pt"><span><br/></span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="12" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31, 2022</span></div></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wholly-Owned Programs<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Controlled Founded Entities</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Parent</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Company &amp;</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Other</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Consolidated</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contract revenue</span></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">590 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,090 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Grant revenue</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,826 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,702 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,528 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total revenue</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,826 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,292 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,618 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative expenses</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,301)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(419)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(52,272)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(60,991)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(116,054)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,051)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(35,328)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(152,433)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total Operating expenses</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(124,355)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,470)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(87,600)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(213,425)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating income/(loss)</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(121,529)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">30 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(76,308)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(197,807)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/expenses not allocated to segments</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense):</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain on deconsolidation</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,251 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on investment held at fair value</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(32,060)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Realized loss on sale of investments</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(29,303)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,131 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total other income/(expense)</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(25,981)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Net finance income/(costs)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">138,924 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share of net income/(loss) of associate accounted for using the equity method</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(27,749)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain on dilution of ownership interest in associate</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28,220 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment of investment in associates</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,390)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/(loss) before taxes </span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,783)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="12" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31, 2022</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Available Funds</span></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash and cash equivalents</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,306 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">823 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">141,737 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149,866 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term Investments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Consolidated cash, cash equivalents and short-term investments</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,306 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">823 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">341,966 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">350,095 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="12" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31, 2021</span></div></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wholly-Owned Programs<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Controlled Founded Entities</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Parent</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Company &amp;</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Other</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Consolidated</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contract revenue</span></td><td colspan="2" style="border-top:0.5pt solid #6d6d6d;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,129 </span></td><td style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #6d6d6d;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.5pt solid #6d6d6d;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">350 </span></td><td style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #6d6d6d;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,979 </span></td><td style="border-top:0.5pt solid #6d6d6d;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Grant revenue</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,253 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,156 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,409 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total revenue</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,382 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,500 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,506 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">17,388 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative expenses</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,673)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(365)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(48,161)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(57,199)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(65,444)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(918)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(44,108)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(110,471)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total operating expense</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(74,118)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,284)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,269)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(167,671)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating income/(loss)</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(64,736)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">216 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(85,763)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(150,282)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/expenses not allocated to segments</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 6.67pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense):</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on investment held at fair value</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">179,316 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Realized loss on sale of investments</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(20,925)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt 2px 12.34pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,592 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other income/(expense)</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">159,983 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Net finance income/(costs)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,050 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share of net income/(loss) of associate accounted for using the equity method</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(73,703)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/(loss) before taxes</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(58,953)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 0 750000 0 750000 853000 0 1727000 2580000 853000 750000 1727000 3330000 14020000 562000 38713000 53295000 89495000 672000 6068000 96235000 103516000 1233000 44781000 149530000 -102662000 -483000 -43054000 -146199000 61787000 77945000 -122000 -27630000 -908000 111072000 5078000 -6055000 -36103000 2140000 675000 188266000 191081000 0 0 136062000 136062000 2140000 675000 324328000 327143000 0 1500000 590000 2090000 2826000 0 10702000 13528000 2826000 1500000 11292000 15618000 8301000 419000 52272000 60991000 116054000 1051000 35328000 152433000 124355000 1470000 87600000 213425000 -121529000 30000 -76308000 -197807000 27251000 -32060000 -29303000 8131000 -25981000 138924000 -27749000 28220000 8390000 -92783000 7306000 823000 141737000 149866000 0 0 200229000 200229000 7306000 823000 341966000 350095000 8129000 1500000 350000 9979000 1253000 0 6156000 7409000 9382000 1500000 6506000 17388000 8673000 365000 48161000 57199000 65444000 918000 44108000 110471000 74118000 1284000 92269000 167671000 -64736000 216000 -85763000 -150282000 179316000 -20925000 1592000 159983000 5050000 -73703000 -58953000 Investments Held at Fair Value<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value include both unlisted and listed securities held by the Group. These investments, which include interests in Akili, Vor, Karuna, Sonde, Vedanta, Gelesis and other insignificant investments, are initially measured at fair value and are subsequently re-measured at fair value at each reporting date with changes in the fair value recorded through profit and loss. Activities related to such investments during the periods are shown below:</span></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investments held at fair value</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">493,888 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Sonde preferred shares - Sonde deconsolidation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,168 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sale of Karuna and Vor shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(118,710)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss realised on sale of investments as a result of written call option</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(29,303)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Akili common shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis Earn-out Shares received in the SPAC exchange</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,214 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exchange of Gelesis preferred shares to Gelesis common shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,303)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss – change in fair value through profit and loss</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(32,060)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022 and January 1, 2023</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">251,892 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Vedanta preferred shares – Vedanta deconsolidation</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">20,456 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Gelesis 2023 Warrants</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,121 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sale of Karuna shares </span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(33,309)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss realised on sale of investments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(265)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain – change in fair value through profit and loss</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">77,945 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023 </span></div></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">317,841</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On March 1, 2023, Vedanta issued convertible debt to a syndicate of investors. The Group did not participate in this round of financing. As part of the issuance of the debt, the convertible debt holders were granted representation on Vedanta's Board of Directors and the Group lost control over the Vedanta Board of Directors and the power to direct the relevant Vedanta activities. Consequently, Vedanta was deconsolidated on March 1, 2023 and its results of operations are included in the Consolidated Financial Statements through the date of deconsolidation.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Following deconsolidation, the Group has significant influence over Vedanta through its voting interest in Vedanta and its remaining representation on Vedanta's Board of Directors. However, the Group only holds convertible preferred shares in Vedanta that do not provide their holders with access to returns associated with a residual equity interest, and as such are accounted for under IFRS 9, as investments held at fair value with changes in fair value recorded in profit and loss. Under IFRS 9, the preferred share investments are categorized as debt instruments that are presented at fair value through profit and loss because the amounts receivable do not represent solely payments of principal and interest.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Upon deconsolidation, the Group derecognized its assets, liabilities and non-controlling interest in respect of Vedanta and recorded its aforementioned investment in Vedanta at fair value. The deconsolidation resulted in a gain of $61,787. As of the date of deconsolidation, the investment in Vedanta convertible preferred shares held at fair value amounted to $20,456.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2023, the Group recognized a loss of $6,303 for the changes in the fair value of the investment in Vedanta that was included in gain/(loss) on investments held at fair value within the Consolidated Statement of Comprehensive Income/(Loss). The fair value of the Group’s investment in Vedanta is $14,153 as of December 31, 2023. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Karuna</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Karuna was deconsolidated in March 2019. During 2019, Karuna completed its IPO and the Group lost its significant influence in Karuna. The shares held in Karuna are accounted for as an investment held at fair value under IFRS 9.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2021</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On February 9, 2021, the Group sold 1,000,000 common shares of Karuna for $118,000. On November 9, 2021, the Group sold an additional 750,000 common shares of Karuna for $100,125. As a result of the aforementioned sales, the Group recorded a loss of $20,925, attributable to blockage discount included in the sales price, in realized gain/(loss) on sale of investments within the Consolidated Statement of Comprehensive Income/(Loss).</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2022</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On August 8, 2022, the Group sold 125,000 shares of Karuna common stock. In addition, the Group wrote a series of call options entitling the holders thereof to purchase up to 477,100 Karuna common stock at a set price, which were exercised in full in August and September 2022. Aggregate proceeds to the Group from all aforementioned transactions amounted to $115,457, net of transaction fees. As a result of the aforementioned sales, the Group recorded a loss of $29,303, attributable to the exercise of the aforementioned call options, in realized gain/(loss) on sale of investment within the Consolidated Statement of Comprehensive Income/(Loss). </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2023</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the three months ended December 31, 2023, the Group sold 167,579 shares of Karuna common stock with aggregate proceeds of $33,309, net of transaction fees. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the years ended December 31, 2023, 2022, and 2021 the Group recorded gains of $107,079, $134,952, $109,987, respectively for the changes in the fair value of the Karuna investment that were included in gain/(loss) on investments held at fair value within the Consolidated Statement of Comprehensive Income/(Loss). As of December 31, 2023, the Group held 886,885 shares or 2.3 percent of total outstanding Karuna common stock. In December 2023, Karuna entered into a definitive merger agreement with Bristol Myers Squibb ("BMS") under which Karuna common shares were acquired by Bristol Myers Squibb for $330 per share in March 2024. See Note 28. Subsequent Events. The fair value of the Group’s investment in Karuna is $280,708 as of December 31, 2023. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vor</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vor was deconsolidated in February 2019. As the Group did not hold common shares in Vor upon deconsolidation and the preferred shares it held did not have equity-like features. Therefore, the preferred shares held by the Group fell under the guidance of IFRS 9 and were treated as a financial asset held at fair value with changes in fair value recorded in the Consolidated Statement of Comprehensive Income/(Loss). </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2021</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On January 8, 2021, the Group participated in the second closing of Vor’s Series B preferred share financing. For consideration of $500, the Group received an additional 961,538 Series B preferred shares. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On February 9, 2021, Vor closed its initial public offering (the "IPO") of 9,828,017 shares of its common stock at a price of $18.00 per share. Subsequent to the closing, the Group held 3,207,200 shares of Vor common stock, representing 8.6 percent of Vor common stock. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2022</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In August and December 2022, the Group sold an aggregate of 535,400 shares of Vor common stock for aggregate proceeds of $3,253.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the years ended December 31, 2023, 2022 and 2021, the Group recognized a loss of $11,756, a loss of $16,247, and a gain of $3,903, respectively, for the changes in the fair value of the investment that were included in gain/(loss) on investments held at fair value within the Consolidated Statement of Comprehensive Income/(Loss). The fair value of the Group’s investment in Vor is $6,012 as of December 31, 2023.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis was deconsolidated in July 2019. The common stock held in Gelesis was accounted for under the equity method, while the preferred shares and warrants held by the Group fell under the guidance of IFRS 9 and were treated as financial assets held at fair value, with changes to the fair value of the instruments recorded through the Consolidated Statement of Comprehensive Income/(Loss). Please refer to Note 6. Investments in Associates for information regarding the Group's investment in Gelesis as an associate.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2021</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2021, as the equity method based investment in Gelesis was reduced to zero previously, the Group allocated a portion of its share in the net loss in Gelesis of $73,703, to its preferred share and warrant investments in Gelesis, which were considered to be long-term interests in Gelesis.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2022</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On January 13, 2022, Gelesis completed its business combination with Capstar Special Purpose Acquisition Corp ("Capstar"). As part of the business combination, all shares in Gelesis, common and preferred, including the shares held by the Group, were exchanged for common shares of the merged entity and unvested common shares that will vest upon the stock price of the new combined entity reaching certain target prices (hereinafter "Gelesis Earn-out Shares"). In addition, the Group invested $15,000 in the class A common shares of Capstar as part of the Private Investment in Public Equity ("PIPE") transaction that took place immediately prior to the closing of the business combination and an additional approximately $4,961, as part of the Backstop agreement signed with Capstar on December 30, 2021 (See Note 6. Investments in Associates). Pursuant to the business combination, Gelesis became a wholly-owned subsidiary of Capstar and Capstar changed its name to Gelesis Holdings, Inc., which began trading on the New York Stock Exchange under the ticker symbol "GLS" on January 14, 2022. The exchange of the preferred stock (including warrants) for common stock (including common stock warrants) represents an additional investment in Gelesis equity investment. The Group recorded the changes in fair value of the preferred stock and warrants through the date of the exchange upon which the preferred shares and warrants were derecognized and recorded as an additional investment in </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis equity interest. All equity method losses allocated in prior periods against the investment in Gelesis held at fair value were reclassified to include within the equity method investment in Gelesis and were offset against the gain on dilution of interest. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As part of the aforementioned exchange, the Group received 4,526,622 Gelesis Earn-out Shares, which were valued on the date of the exchange at $14,214. The Group accounted for such Gelesis Earn-out Shares under IFRS 9 as investments held at fair value with changes in fair value recorded through profit and loss.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2023</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In February and May 2023, as part of Gelesis' issuance of senior secured promissory notes to the Group, Gelesis also issued to the Group (i) warrants to purchase 23,688,047 shares of Gelesis common stock with an exercise price of $0.2744 per share (ii) warrants to purchase 192,307,692 shares of Gelesis common stock at an exercise price of $0.0182 per share and (iii) warrants to purchase 43,133,803 shares of Gelesis common stock at an exercise price of $0.0142 per share. These warrants expire five years after issuance and are collectively referred to as the Gelesis 2023 Warrants.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Gelesis 2023 Warrants were recorded at their initial fair value of $1,121 and then subsequently re-measured to fair value through the profit and loss. As of December 31, 2023, the fair value of the Gelesis 2023 Warrants was $0 as Gelesis ceased operations in October 2023</span><span style="color:#000000;font-family:'Arial',sans-serif;font-size:11pt;font-weight:400;line-height:120%">.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the years ended December 31, 2023, 2022 and 2021, the Group recognized a loss of $1,264, a loss of $18,476 and a gain of $34,566, respectively, related to the change in the fair value of these instruments that was included in gain/(loss) on investments held at fair value within the Consolidated Statement of Comprehensive Income/(Loss). </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sonde</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On May 25, 2022, Sonde completed a Series B preferred share financing, which resulted in the Group losing control over Sonde and the deconsolidation of Sonde. Therefore, the results of operations of Sonde are included in the Consolidated Financial Statements through the date of deconsolidation.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Upon deconsolidation, the Group derecognized its assets and liabilities and non-controlling interest in respect of Sonde and recorded its aforementioned investments in Sonde at fair value. The deconsolidation resulted in a gain of $27,251. As of the date of deconsolidation, the investment in Sonde preferred shares held at fair value amounted to $11,168. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Following deconsolidation, the Group had significant influence in Sonde through its 48.2% voting interest in Sonde and its remaining representation on Sonde's Board of Directors. The Group holds Preferred A-1, A-2 and B shares. The Preferred A-1 shares have the same terms as common stock and provide their shareholders with access to returns associated with a residual equity ownership in Sonde. Consequently, the investment in Preferred A-1 shares is accounted for under the equity method. The convertible Preferred A-2 and B shares do not provide their shareholders with access to returns associated with a residual equity interest and as such are accounted for under IFRS 9, as investments held at fair value with changes in fair value recorded in profit and loss. Under IFRS 9, the A-2 and B preferred share investments are categorized as debt instruments that are presented at fair value through profit and loss because the amounts receivable do not represent solely payments of principal and interest.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the years ended December 31, 2023 and 2022, the Group recognized a loss of $994, and a gain of $235, respectively, for the changes in the fair value of the investment in Sonde that were included in gain/(loss) on investments held at fair value within the Consolidated Statement of Comprehensive Income/(Loss). The fair value of the Group’s investment in Sonde is $10,408 as of December 31, 2023. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Akili</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Akili was deconsolidated in 2018. At time of deconsolidation, as the Group did not hold common shares in Akili and the preferred shares it held did not have equity-like features. Therefore, the preferred shares held by the Group fell under the guidance of IFRS 9 and were treated as a financial asset held at fair value and changes to the fair value of the preferred shares were recorded through the Consolidated Statement of Comprehensive Income/(Loss), in accordance with IFRS 9. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On May 25, 2021, Akili completed its Series D financing for gross proceeds of $110,000 in which Akili issued 13,053,508 Series D preferred shares. The Group did not participate in this round of financing and as a result, the Group's interest in Akili was reduced from 41.9 percent to 27.5 percent.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On August 19, 2022, Akili Interactive merged with Social Capital Suvretta Holdings Corp. I, a special purpose acquisition company. The combined company's securities began trading on August 22, 2022 on the Nasdaq Stock Market under the ticker symbol "AKLI". As part of this transaction, the Akili Interactive shares held by the Group were exchanged for the common stock of the combined company's securities as well as unvested common stock ("Akili Earnout Shares") that will vest when the share price exceeds certain thresholds. In addition, as part of a PIPE transaction that took place concurrently with the closing of the transaction, the Group purchased 500,000 shares for a total consideration of $5,000. Following the closing of the aforementioned transactions, the Group holds 12,527,477 shares of the combined entity and 1,433,914 Akili Earn-out Shares, with fair value amounted to $6,422 as of December 31, 2023.</span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the years ended December 31, 2023, 2022 and 2021, the Group recognized a loss of $8,681, a loss of $131,419, and a gain of $32,151, respectively, for the changes in the fair value of the investment in Akili that were included in gain/(loss) on investments held at fair value within the Consolidated Statement of Comprehensive Income/(Loss).</span></div> Activities related to such investments during the periods are shown below:<div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investments held at fair value</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">493,888 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Sonde preferred shares - Sonde deconsolidation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,168 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sale of Karuna and Vor shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(118,710)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss realised on sale of investments as a result of written call option</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(29,303)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Akili common shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis Earn-out Shares received in the SPAC exchange</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,214 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exchange of Gelesis preferred shares to Gelesis common shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,303)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss – change in fair value through profit and loss</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(32,060)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022 and January 1, 2023</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">251,892 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Vedanta preferred shares – Vedanta deconsolidation</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">20,456 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Gelesis 2023 Warrants</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,121 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sale of Karuna shares </span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(33,309)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss realised on sale of investments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(265)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain – change in fair value through profit and loss</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">77,945 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023 </span></div></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">317,841</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 493888000 11168000 118710000 29303000 5000000 14214000 -92303000 -32060000 251892000 20456000 1121000 33309000 265000 77945000 317841000 61787000 20456000 -6303000 14153000 1000000 118000000 750000 100125000 20925000 125000 477100 115457000 29303000 167579 33309000 107079000 134952000 109987000 886885 0.023 330 280708000 500000 961538 9828017 18.00 3207200 0.086 535400 3253000 -11756000 -16247000 3903000 6012000 0 73703000 15000000 4961000 4526622 14214000 23688047 0.2744 192307692 0.0182 43133803 0.0142 P5Y 1121000 0 -1264000 -18476000 34566000 27251000 11168000 0.482 -994000 235000 10408000 110000000 13053508 0.419 0.275 500000 5000000 12527477 1433914 6422000 -8681000 -131419000 32151000 Investments in Associates<div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis was founded by the Group and raised funding through preferred shares financings as well as issuances of warrants and loans. As of July 1, 2019, Gelesis was deconsolidated from the Group’s financial statements. Upon deconsolidation, the preferred shares and warrants held by the Group fell under the guidance of IFRS 9 </span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Financial Instruments</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> and were treated as financial assets held at fair value and the investment in common shares of Gelesis was subject to IAS 28 </span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Investment in Associates</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> as the Group had significant influence over Gelesis. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2021</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Due to the Group's share in the losses of Gelesis, in 2020, the Group's investment in Gelesis accounted for under the equity method was reduced to zero. Since the Group had investments in Gelesis warrants and preferred shares that were deemed to be long-term interests, the Group continued recognizing its share in Gelesis losses while applying such losses to its preferred share and warrant investment in Gelesis accounted for as an investment held at fair value. In 2021, total investment in Gelesis, including the long-term interests, was reduced to zero. Since the Group did not incur legal or constructive obligations or made payments on behalf of Gelesis, the Group discontinued recognizing equity method losses in 2021. As of December 31, 2021, unrecognized equity method losses amounted to $38,101, which included $709 of unrecognized other comprehensive loss.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During 2021, due to exercise of stock options into common shares in Gelesis, the Group's equity interest in Gelesis was reduced from 47.9 percent at December 31, 2020 to 42.0 percent as of December 31, 2021. The gain resulting from the issuance of shares to third parties and the resulting reduction in the Group's share in the accumulated deficit of Gelesis under the equity method was fully offset by the unrecognized equity method losses.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Backstop agreement – 2022 and 2021</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On December 30, 2021, the Group signed a Backstop agreement with Capstar and had committed to acquire Capstar class A common shares at $10 per share immediately prior to the closing of the business combination between Gelesis and Capstar, in case, the Available Funds, as defined in the agreement, were less than $15,000. According to the Backstop agreement, if the Group had to acquire any shares under the agreement, the Group would receive an additional 1,322,500 class A common shares of Capstar at no additional consideration.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group determined that such agreement meets the definition of a derivative under IFRS 9 and as such should be recorded at fair value with changes in fair value recorded through profit and loss. The derivative was initially recorded at fair value adjusted to defer the day 1 gain equal to the difference between the fair value of $11,200 and transaction price of zero on the effective date of the Backstop agreement and as such was initially recorded at zero. The deferred gain was amortized over the period from the effective date until settlement date, January 13, 2022. During the years ended December 31, 2022 and 2021, the Group recognized income of $10,400 and $800, respectively, for the amortization of the deferred gain. During the year ended December 31, 2022, the Group recognized a loss of $2,776 in respect of the decrease in the fair value of the derivative until the settlement date, resulting in a net gain of $7,624 recorded during the year ended December 31, 2022 in respect of the Backstop agreement. The gain was included in other Income/(expense) in the Consolidated Statement of Comprehensive Income/(Loss). The fair value of the derivative on the settlement date in the amount of $8,424 represents an additional investment in Gelesis as part of the SPAC transaction described below.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On January 13, 2022, as part of the conclusion of the aforementioned Backstop agreement, the Group acquired 496,145 class A common shares of Capstar for $4,961 and received an additional 1,322,500 class A common shares of Capstar for no additional consideration.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2022</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Share exchange – Capstar</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On January 13, 2022, Gelesis completed its business combination with Capstar. As part of the business combination, all shares in Gelesis, common and preferred, including the shares held by the Group, were exchanged for common shares of the merged entity and unvested common shares that will vest upon the stock price of the new combined entity reaching certain target prices (the "Gelesis Earn-out Shares"). In addition, the Group invested $15,000 in the class A common shares of Capstar as part of the PIPE transaction that took place immediately prior to the closing of the business combination and an additional $4,961, as part of the Backstop agreement described above. Pursuant to the business combination, Gelesis became a wholly-owned subsidiary of Capstar and Capstar changed its name to Gelesis Holdings, Inc., which began trading on the New York Stock Exchange under the ticker symbol "GLS" on January 14, 2022. Following the closing of the business combination, the PIPE transaction, the settlement of the aforementioned Backstop agreement with Capstar, and the exchange of all preferred shares in Gelesis to common shares in the new combined entity, the Group holds 16,727,582 common shares of Gelesis Holdings Inc., which was equal to approximately 23.2% of Gelesis Holdings Inc's outstanding common shares at the time of the exchange. Due to the Group's significant equity holding and voting interest in Gelesis, the Group continued to maintain significant influence in Gelesis and as such continued to account for its Gelesis equity investment under the equity method.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis was deemed to be the acquirer in Gelesis Holdings Inc. and the financial assets and financial liabilities in Capstar were deemed to be acquired by Gelesis in consideration for the shares held by Capstar legacy shareholders. As such, the Group did not revalue the retained investment in Gelesis but rather treated the exchange as a dilution of its equity interest in Gelesis from 42.0 percent as of December 31, 2021 to 22.8 percent as of January 13, 2022 (including warrants that provide its holders access to returns associated with equity holders). After considering the aforementioned additional investments, the exchange of the preferred stock, previously accounted for as an investment held at fair value, to common stock (and representing an additional equity investment in Gelesis), the earn-out shares received in Gelesis (see Note 5. Investments Held at Fair Value) and the offset of previously unrecognized equity method losses, the net gain recorded on the dilution of interest amounted to $28,255.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Impairment</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Following Gelesis’ decline in its market price in 2022 and its lack of liquidity, the Group recorded an impairment loss of $8,390 as of December 31, 2022 in respect of its investment in Gelesis. The recoverable amount of the investment in Gelesis was $4,910 as of December 31, 2022, which was determined based on fair value less costs to sell (which were estimated to be insignificant). Fair value was determined based on level 1 of the fair value hierarchy as Gelesis shares were traded on an active market as of December 31, 2022.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The impairment loss was presented separately in the Consolidated Statement of Comprehensive Income/(loss) for the year ended December 31, 2022 in the line item impairment of investment in associates.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">2023</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2023, the Group entered into agreements with Gelesis to purchase senior secured convertible promissory notes and warrants for shares of Gelesis common stock (see Note 7. Investment in Notes from Associates). The warrants to purchase shares of Gelesis common stock represented potential voting rights to the Group and it is therefore </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">necessary to consider whether they were substantive. If these potential voting rights were substantive and the Group had the practical ability to exercise the rights and take control of greater than 50% of Gelesis common stock, the Group would be required to consolidate Gelesis under the accounting standards.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In February 2023, the Group obtained warrants to purchase 23,688,047 shares of Gelesis common stock (the “February Warrants”) at an exercise price of $0.2744 per share. The exercise of the February Warrants was subject to the approval of the Gelesis stockholders until May 1, 2023. On May 1, 2023, stockholder approval was no longer required for the Group to exercise the February Warrants. The potential voting rights associated with the February Warrants were not substantive as the exercise price of the February Warrants was at a significant premium to the fair value of the Gelesis common stock.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In May 2023, the Group obtained warrants to purchase 235,441,495 shares of Gelesis common stock (the “May Warrants”). The May Warrants were exercisable at the option of the Group and had an exercise price of either $0.0182 or $0.0142. The May Warrants were substantive as the Group would have benefited from exercising such warrants since their exercise price was at the money or at an insignificant premium over the fair value of the Gelesis common stock. However, that benefit from exercising the May Warrants only existed for a short period of time because in June 2023, the potential voting rights associated with the May Warrants were impacted by the terms and conditions of the Merger Agreement as described below and were no longer substantive. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In October 2023, the Group terminated the Merger Agreement with Gelesis and the potential voting rights associated with the May Warrants were not substantive. Also, in October 2023, Gelesis ceased operations and filed a voluntary petition for relief under the provisions of Chapter 7 of Title 11 of the United States Bankruptcy Code. A Chapter 7 trustee has been appointed by the Bankruptcy Court who has control over the assets and liabilities of Gelesis, effectively eliminating the authority and powers of the Board of Directors of Gelesis and its executive officers to act on behalf of Gelesis. The assets of Gelesis will be liquidated and Gelesis no longer has any officers or employees. The Group ceased accounting for Gelesis as an equity method investment as it no longer had significant influence in Gelesis. During the year ended December 31, 2023, the Group recorded $4,910 as its share in the losses of Gelesis and the Group’s balance in this equity method investment was zero as of December 31, 2023. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Merger Agreement </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On June 12, 2023, PureTech Health LLC and Caviar Merger Sub LLC, a Delaware limited liability company and a wholly-owned subsidiary of PureTech (“Merger Sub”), entered into an agreement (the "Merger Agreement"), pursuant to which Gelesis would merge with and into Merger Sub, with Merger Sub continuing as the surviving company ( the “Merger”). If the Merger had been completed, PureTech would have acquired all issued and outstanding shares of common stock of Gelesis not otherwise held by PureTech, and Gelesis would have become an indirect wholly-owned subsidiary of PureTech. On October 12, 2023, the Group terminated the Merger Agreement. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sonde</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On May 25, 2022, Sonde completed a Series B preferred share financing. As a result of the aforementioned financing, the Group's voting interest was reduced below 50% and the Group lost its control over Sonde and as such ceased to consolidate Sonde on the date the round of financing was completed. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Following deconsolidation, the Group has significant influence in Sonde through its voting interest in Sonde and its remaining representation on Sonde's Board of Directors. The Group's voting interest at date of deconsolidation and as of December 31, 2022 was 48.2% and 40.17%, respectively. The Group holds Preferred A-1, A-2 and B shares. The Preferred A-1 shares, in substance, have the same terms as common stock and as such provide their shareholders with access to returns associated with a residual equity ownership in Sonde. Consequently, the investment in Preferred A-1 shares is accounted for under the equity method. The Preferred A-2 and B shares, however, do not provide their shareholders with access to returns associated with a residual equity interest and as such are accounted for under IFRS 9, as investments held at fair value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of the Preferred A-1 shares on the date of deconsolidation amounted to $7,716, which is the initial value of the equity method investment in Sonde. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the years ended December 31, 2023 and 2022, the Group recorded losses of $1,052 and $3,443, respectively, related to Sonde's equity method of accounting. As of December 31, 2023, the Sonde equity method investment has a balance of $3,185.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes the activity related to the investment in associates balance for the years ended December 31, 2023 and 2022.</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment in Associates</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">As of January 1, 2022</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash investment in associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">19,961 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additional investment as a result of settling the Backstop agreement (see above)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,424 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain on dilution of interest in associate (*)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,793 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Sonde - deconsolidation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,680 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share in net loss of associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(27,749)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reversal of equity method losses recorded against LTI (due to decrease in the fair value of such LTI):</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(4,406)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share in other comprehensive loss of associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(166)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,390)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">As of December 31, 2022 and January 1, 2023</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,147 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share in net loss of associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,055)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share in other comprehensive income of associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">92 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">As of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,185</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">*    Gain on dilution of interest was further increased due to the receipt of Gelesis Earn-out Shares accounted for as investments held at fair value (see above).</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Summarized financial information</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes the financial information of Gelesis as of December 31, 2022 and for the years ended December 31, 2022 and 2021, as included in its own financial statements, adjusted for fair value adjustments at deconsolidation and differences in accounting policies. The table also reconciles the summarized financial information to the carrying amount of the Group’s interest in Gelesis. As of December 31, 2023, the Group’s investment in Gelesis is $0 and Gelesis does not represent a significant equity method investment. As a result, such a disclosure for Gelesis is not presented for the year ended December 31, 2023. </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:0 1pt"></td></tr><tr style="height:12pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of and for the year ended December 31,</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Percentage ownership interest</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22.5 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-current assets</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">333,040 </span></td><td style="border-top:0.25pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Current assets</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">23,495 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-current liabilities</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(99,053)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Current liabilities</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(80,010)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-controlling interests and options issued to third parties</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(46,204)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Net assets (deficit) attributable to shareholders of Gelesis Inc.</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">131,268 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Group's share of net assets (net deficit)</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,504 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Goodwill</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,858 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment </span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(28,452)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Investment in associates</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,910 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr style="height:11pt"><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" rowspan="2" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:11pt"><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revenue</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25,767 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,185 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss from continuing operations (100%)</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(111,567)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(271,430)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total comprehensive loss (100%)</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(112,285)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(273,005)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Group's share in net losses - limited to net investment amount (*)</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24,306)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(73,703)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Group's share of total comprehensive loss - limited to net investment amount</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24,472)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(73,703)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">*    For the year ended December 31, 2022, the amount includes $4,406 reversal of equity method losses recorded against long-term Interests ("LTI") due to the decrease in fair value of such LTI.</span></div>Investment in Notes from Associates <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Unsecured Promissory Note</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On July 27, 2022, the Group, as a lender, entered into an unsecured promissory note (the "Junior Note") with Gelesis, as a borrower, in the amount of $15,000. The Junior Note bears an annual interest rate of 15% per annum. The maturity date of the Junior Note is the earlier of December 31, 2023 or five business days following the consummation of a qualified financing by Gelesis. Based on the terms of the Junior Note, due to the option to convert to a variable amount of shares at the time of default, the Junior Note is required to be measured at fair value with changes in fair value recorded through profit and loss. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023 and December 31, 2022 the fair value of the Junior Note was $0 and $16,501, respectively. In the year ended December 31, 2023, the Group recorded a loss of $16,501 for the change in the fair value of the Junior Note which was included in gain/(loss) on investments in notes from associates within the Consolidated Statement of Comprehensive Income/(Loss). The fair value of the Junior Note was determined to be $0 as of December 31, 2023 as Gelesis has ceased operations and filed for bankruptcy. In the year ended December 31, 2022, the Group recorded interest income of $963 and a gain of $539 for the change in the fair value of the Junior Note which was included in other income/(expense) in the Consolidated Statement of Comprehensive Income/(Loss). </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Senior Secured Convertible Promissory Notes</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2023, the Group entered into multiple agreements with Gelesis to purchase for $11,850 senior secured convertible promissory notes (the "Senior Notes") and warrants for share of Gelesis common stock. The initial fair value of the Senior Notes was determined to be $10,729 while $1,121 was determined to be the initial fair value of the warrants. The Senior Notes represent debt instruments that are presented at fair value through profit and loss as the amounts receivable do not solely represent payments of principal and interest as the Senior Notes are convertible into Gelesis common stock. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Senior Notes are secured by a first-priority lien on substantially all assets of Gelesis and the guarantors (other than the equity interests in, and assets held by Gelesis s.r.l., a subsidiary of Gelesis, and certain other exceptions).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In October 2023, Gelesis ceased operations and filed a voluntary petition for relief under the provisions of Chapter 7 of Title 11 of the United States Bankruptcy Code. Therefore, the Group determined that the fair value of the Senior Notes was $0 as of December 31, 2023 and the Group recorded a loss of $10,729 for the changes in the fair value of the Senior Notes. The loss was included in gain/(loss) on investments in notes from associates in the Consolidated Statement of Comprehensive Income/(Loss). </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On April 24, 2023, Vedanta closed the second tranche of its convertible debt for additional proceeds of $18,000, of which $5,000 were invested by the Group. The convertible debt carries an interest rate of 9 percent per annum. The debt has various conversion triggers and the conversion price is established at the lower of 80% of the equity price of the last financing round, or a certain pre-money valuation cap established in the agreement. If the convertible debt is not earlier converted or repaid, the entire outstanding amount of the convertible debt shall be due and payable upon the earliest to occur of (a) the later of (x) November 1, 2025 and (y) the date which is sixty (60) days after all amounts owed under, or in connection with, the loan Vedanta received from a certain investor have been paid in full, or (b) the consummation of a Deemed Liquidation Event (as defined in Vedanta’s Amended and Restated Certificate of Incorporation).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Due to the terms of the convertible debt, the investment in such convertible debt is measured at fair value with changes in the fair value recorded through profit and loss. During the years ended December 31, 2023, the Group recorded a loss of $400 for the changes in the fair value of the Vedanta convertible debt which was included in gain/(loss) on investments in notes from associates in the Consolidated Statement of Comprehensive Income/(Loss). </span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:112%">Following is the activity in respect of investments in notes from associates during the periods</span><span style="color:#000000;font-family:'Arial',sans-serif;font-size:11pt;font-weight:400;line-height:112%">.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:112%"> The fair value of the $4,600 note from associate as of December 31, 2023 is determined using unobservable Level 3 inputs. See Note 18. Financial Instruments for additional information.</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment in notes from associates</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment In Gelesis notes</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the fair value of the notes</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022 and January 1, 2023</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">16,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment In Gelesis notes</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,729 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Vedanta convertible debt</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the fair value of the notes and convertible debt</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(27,630)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023 </span></div></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,600</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 0 0 38101000 709000 0.479 0.42 10 15000000 1322500 0 11200000 0 0 10400000 800000 -2776000 7624000 8424000 496145 4961000 1322500 0 15000000 4961000 16727582 0.232 0.42 0.228 28255000 8390000 4910000 23688047 0.2744 235441495 0.0182 0.0142 4910000 0 0.482 0.4017 7716000 -1052000 -3443000 3185000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes the activity related to the investment in associates balance for the years ended December 31, 2023 and 2022.</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment in Associates</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">As of January 1, 2022</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash investment in associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">19,961 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additional investment as a result of settling the Backstop agreement (see above)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,424 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain on dilution of interest in associate (*)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,793 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Sonde - deconsolidation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,680 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share in net loss of associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(27,749)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reversal of equity method losses recorded against LTI (due to decrease in the fair value of such LTI):</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(4,406)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share in other comprehensive loss of associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(166)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,390)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">As of December 31, 2022 and January 1, 2023</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,147 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share in net loss of associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,055)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share in other comprehensive income of associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">92 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">As of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,185</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">*    Gain on dilution of interest was further increased due to the receipt of Gelesis Earn-out Shares accounted for as investments held at fair value (see above).</span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:112%">Following is the activity in respect of investments in notes from associates during the periods</span><span style="color:#000000;font-family:'Arial',sans-serif;font-size:11pt;font-weight:400;line-height:112%">.</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:112%"> The fair value of the $4,600 note from associate as of December 31, 2023 is determined using unobservable Level 3 inputs. See Note 18. Financial Instruments for additional information.</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment in notes from associates</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment In Gelesis notes</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the fair value of the notes</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022 and January 1, 2023</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">16,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment In Gelesis notes</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,729 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Vedanta convertible debt</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in the fair value of the notes and convertible debt</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(27,630)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023 </span></div></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,600</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 0 19961000 8424000 13793000 7680000 -27749000 4406000 -166000 8390000 9147000 -6055000 92000 3185000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes the financial information of Gelesis as of December 31, 2022 and for the years ended December 31, 2022 and 2021, as included in its own financial statements, adjusted for fair value adjustments at deconsolidation and differences in accounting policies. The table also reconciles the summarized financial information to the carrying amount of the Group’s interest in Gelesis. As of December 31, 2023, the Group’s investment in Gelesis is $0 and Gelesis does not represent a significant equity method investment. As a result, such a disclosure for Gelesis is not presented for the year ended December 31, 2023. </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:0 1pt"></td></tr><tr style="height:12pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of and for the year ended December 31,</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Percentage ownership interest</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22.5 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-current assets</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">333,040 </span></td><td style="border-top:0.25pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Current assets</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">23,495 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-current liabilities</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(99,053)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Current liabilities</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(80,010)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-controlling interests and options issued to third parties</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(46,204)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Net assets (deficit) attributable to shareholders of Gelesis Inc.</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">131,268 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Group's share of net assets (net deficit)</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,504 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Goodwill</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,858 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment </span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(28,452)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Investment in associates</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,910 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr style="height:11pt"><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="display:none"></td><td colspan="3" rowspan="2" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:11pt"><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revenue</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25,767 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,185 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss from continuing operations (100%)</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(111,567)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(271,430)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total comprehensive loss (100%)</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(112,285)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(273,005)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Group's share in net losses - limited to net investment amount (*)</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24,306)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(73,703)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Group's share of total comprehensive loss - limited to net investment amount</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24,472)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(73,703)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">*    For the year ended December 31, 2022, the amount includes $4,406 reversal of equity method losses recorded against long-term Interests ("LTI") due to the decrease in fair value of such LTI.</span></div> 0 0.225 333040000 23495000 99053000 80010000 46204000 131268000 29504000 3858000 28452000 4910000 25767000 11185000 -111567000 -271430000 -112285000 -273005000 -24306000 -73703000 -24472000 -73703000 4406000 15000000 0.15 5 0 16501000 -16501000 0 963000 539000 11850000 -10729000 1121000 0 -10729000 18000000 5000000 0.09 0.80 P60D -400000 4600000 0 15000000 1501000 16501000 10729000 5000000 -27630000 4600000 Operating Expenses <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total operating expenses were as follows:</span></div><div style="margin-bottom:5.25pt;margin-top:9pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ending December 31,</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">53,295</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">60,991 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57,199 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">96,235</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">152,433 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">110,471 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total operating expenses</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">149,530</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">213,425 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">167,671 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The average number of persons employed by the Group during the year, analyzed by category, was as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ending December 31,</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">40</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">52 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">56</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">144 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">119 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">96</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">201 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">171 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The aggregate payroll costs of these persons were as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ending December 31,</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">24,586</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25,322 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26,438 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21,102</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">36,321 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28,950 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">45,688</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">61,643 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">55,388 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Detailed operating expenses were as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ending December 31,</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Salaries and wages</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">37,084</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">41,750 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">36,792 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Healthcare and other benefits</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,599</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,908 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,563 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Payroll taxes</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,590</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,286 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,084 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,415</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,699 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,950 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total payroll costs</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">45,688</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">61,643 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">55,388 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amortization </span></div></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,979</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,048 </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,940 </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,955</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,845 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,347 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total amortization and depreciation expenses</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,933</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,893 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,287 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other general and administrative expenses</span></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">25,180</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">31,600 </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26,714 </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other research and development expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">73,729</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">111,288 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">78,282 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total other operating expenses</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">98,909</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">142,888 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">104,996 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total operating expenses</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">149,530</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">213,425 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">167,671 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Please refer to Note 9. Share-based Payments for further disclosures related to share-based payments and Note 26. Related Parties Transactions for management’s remuneration disclosures.</span></div> <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total operating expenses were as follows:</span></div><div style="margin-bottom:5.25pt;margin-top:9pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ending December 31,</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">53,295</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">60,991 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57,199 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">96,235</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">152,433 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">110,471 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total operating expenses</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">149,530</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">213,425 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">167,671 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Detailed operating expenses were as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ending December 31,</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Salaries and wages</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">37,084</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">41,750 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">36,792 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Healthcare and other benefits</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,599</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,908 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,563 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Payroll taxes</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,590</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,286 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,084 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,415</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,699 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,950 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total payroll costs</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">45,688</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">61,643 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">55,388 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amortization </span></div></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,979</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,048 </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,940 </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,955</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,845 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,347 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total amortization and depreciation expenses</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,933</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,893 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,287 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other general and administrative expenses</span></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">25,180</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">31,600 </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26,714 </span></td><td style="border-top:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other research and development expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">73,729</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">111,288 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">78,282 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total other operating expenses</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">98,909</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">142,888 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">104,996 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total operating expenses</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">149,530</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">213,425 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">167,671 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 53295000 60991000 57199000 96235000 152433000 110471000 149530000 213425000 167671000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The average number of persons employed by the Group during the year, analyzed by category, was as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ending December 31,</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">40</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">52 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">56</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">144 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">119 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">96</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">201 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">171 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 40 57 52 56 144 119 96 201 171 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The aggregate payroll costs of these persons were as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ending December 31,</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">24,586</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25,322 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26,438 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21,102</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">36,321 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">28,950 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">45,688</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">61,643 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">55,388 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 24586000 25322000 26438000 21102000 36321000 28950000 45688000 61643000 55388000 37084000 41750000 36792000 2599000 2908000 2563000 1590000 2286000 2084000 4415000 14699000 13950000 45688000 61643000 55388000 1979000 3048000 2940000 2955000 5845000 4347000 4933000 8893000 7287000 25180000 31600000 26714000 73729000 111288000 78282000 98909000 142888000 104996000 149530000 213425000 167671000 <span style="color:#183964;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Share-based Payments</span><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payments includes stock options, time-based restricted stock units (“RSUs”) and performance-based RSUs in which the expense is recognized based on the grant date fair value of these awards, except for performance-based RSUs to executives that are treated as liability awards where expense is recognized based on reporting date fair value up until settlement date.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based Payment Expense</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group's share-based payment expense for the years ended December 31, 2023, 2022 and 2021, was $4,415, $14,699, and $13,950 respectively. The following table provides the classification of the Group’s consolidated share-based payment expense as reflected in the Consolidated Statement of Income/(Loss):</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Year ended December 31,</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,185</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,862 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,310 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,230</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,837 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,640 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,415</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,699 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,950 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Performance Share Plan</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In June 2015, the Group adopted the Performance Stock Plan (the “2015 PSP”). Under the 2015 PSP and subsequent amendments, awards of ordinary shares may be made to the Directors, senior managers and employees, and other individuals providing services to the Group up to a maximum authorized amount of 10.0 percent of the total ordinary shares outstanding. The shares have various vesting terms over a period of service between <span style="-sec-ix-hidden:f-1294">one</span> and four years, provided the recipient remains continuously engaged as a service provider. The options awards expire 10 years from the grant date.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In June 2023 the Group adopted a new Performance Stock Plan (the "2023 PSP") that has the same terms as the 2015 PSP but instituted for all new awards a limit of 10.0 percent of the total ordinary shares outstanding over a five-year period.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The share-based awards granted under the PSPs are generally equity-settled (see cash settlements below). As of December 31, 2023, the Group had issued 27,384,777 units of share-based awards under these plans.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSU activity for the years ended December 31, 2023, 2022 and 2021 is detailed as follows:</span></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Number of Shares/Units</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Weighted Average Grant Date Fair Value (GBP) (*)</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding (Non-vested) at January 1, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,422,582 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.46 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs Granted in Period</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,195,133 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.15 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vested</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,176,695)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.93 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(808,305)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.25 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding (Non-vested) at December 31, 2021 and January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,632,715 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.91 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs Granted in Period</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,309,883 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.76 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vested</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(696,398)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.80 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,155,420)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.67 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding (Non-vested) at December 31, 2022 and January 1, 2023</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6,090,780</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.74</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs Granted in Period</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,679,669 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.28 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vested</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(716,029)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.00 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,880,274)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.94 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding (Non-vested) at December 31, 2023</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">7,174,146</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.10</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">*    For liability awards - based on fair value at reporting date.</span></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span><br/></span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Each RSU entitles the holder to one ordinary share on vesting and the RSU awards are generally based on a vesting schedule over a <span style="-sec-ix-hidden:f-1328">one</span> to three-year requisite service period in which the Group recognizes compensation expense for the RSUs. Following vesting, each recipient will be required to make a payment of one pence per ordinary share on settlement of the RSUs. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs granted to the non-executive directors are time-based and equity-settled. The grant date fair value on such RSUs is recognized over the vesting term.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs granted to executives are performance-based and vesting of such RSUs is subject to the satisfaction of both performance and market conditions. The performance condition is based on the achievement of the Group's strategic targets. The market conditions are based on the achievement of the absolute total shareholder return (“TSR”), TSR as compared to the FTSE 250 Index, and TSR as compared to the MSCI Europe Health Care Index. The RSU award performance criteria have changed over time as the criteria are continually evaluated by the Group’s Remuneration Committee.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group recognizes the estimated fair value of performance-based awards with non-market conditions as share-based compensation expense over the performance period based upon its determination of whether it is probable that the performance targets will be achieved. The Group assesses the probability of achieving the performance targets at each reporting period. Cumulative adjustments, if any, are recorded to reflect subsequent changes in the estimated outcome of performance-related conditions.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of the performance-based awards with market conditions is based on the Monte Carlo simulation analysis utilizing a Geometric Brownian Motion process with 100,000 simulations to value those shares. The model considers share price volatility, risk-free rate and other covariance of comparable public companies and other market data to predict distribution of relative share performance.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Liability settled RSUs classification</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The RSUs to executives are treated as liability awards as the Group has a historical practice of settling these awards in cash, and as such adjusted to fair value at every reporting date until settlement with changes in fair value recorded in earnings as stock based compensation expense.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group incurred share-based payment expenses for RSUs of $827 (including $402 expense in respect of RSU liability awards), $1,637 (including $1,131 expense in respect of RSU liability awards), and $1,540 (including $589 expense in respect of RSU liability awards) for the years ended December 31, 2023, 2022 and 2021, respectively. The decrease in the share-based compensation expense in respect of the RSUs for the year ended December 31, 2023, as compared to the year ended December 31, 2022 is due to reduction in the fair value of the liability awards.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023, the carrying amount of the RSU liability awards was $4,782, $1,281 current; $3,501 non current, out of which $1,283 related to awards that have met all their performance and market conditions.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Stock Options</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Stock option activity for the years ended December 31, 2023, 2022 and 2021, is detailed as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Number of Options</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd Average Exercise Price (GBP)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd Average of<br/>remaining contractual<br/>term (in years)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd Average Stock Price at Exercise (GBP)</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding at January 1, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,916,086 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.81 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.38</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Granted</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,424,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.34 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exercised</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,238,187)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.70 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.63</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited and expired</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(687,781)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.53 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.19pt;font-weight:700;line-height:120%">Options Exercisable at December 31, 2021 and January 1, 2022</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,773,873 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.42 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6.50</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding at December 31, 2021 and January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,414,118 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.58 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.29</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Granted</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,881,000 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.04 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exercised</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(577,022)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.50 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.43</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited and expired</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,924,215)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.89 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.19pt;font-weight:700;line-height:120%">Options Exercisable at December 31, 2022 and January 1, 2023</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6,185,216</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.03</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6.21</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding at December 31, 2022 and January 1, 2023</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">17,793,881</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.31</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">8.03</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Granted</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,120,975 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.22 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exercised</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(534,034)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.71 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.46</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited and expired</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,424,232)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.40 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Options Exercisable at December 31, 2023</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">9,065,830</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.19</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6.01</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding at December 31, 2023</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">16,956,590</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.29</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">7.20</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of the stock options awarded by the Group was estimated at the grant date using the Black-Scholes option valuation model, considering the terms and conditions upon which options were granted, with the following weighted-average assumptions:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">At December 31,</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Expected volatility</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">43.69</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">41.70 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">41.05 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Expected terms (in years)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6.16</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6.11</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6.16</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Risk-free interest rate</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4.04</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.13 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.06 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Expected dividend yield</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exercise price (GBP)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.22</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.04</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.34</span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Underlying stock price (GBP)</span></td><td colspan="3" style="border-bottom:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.22</span></td><td colspan="3" style="border-bottom:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.04</span></td><td colspan="3" style="border-bottom:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.34</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">These assumptions resulted in an estimated weighted-average grant-date fair value per share of stock options granted during the years ended December 31, 2023, 2022 and 2021 of $1.37 ,$1.15 and $1.87, respectively.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group incurred share-based payment expense for the stock options of $3,310, $8,351 and $6,158 for the years ended December 31, 2023, 2022 and 2021, respectively. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For shares outstanding as of December 31, 2023, the range of exercise prices is detailed as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Range of Exercise Prices (GBP)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Options<br/>Outstanding</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd<br/>Average<br/>Exercise<br/>Price (GBP)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd Average of<br/>remaining contractual<br/>term (in years)</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.01</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">439,490 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5.76</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.00 to 2.00</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,989,572 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.54 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5.64</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.00 to 3.00</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,664,028 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.25 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.55</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.00 to 4.00</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,863,500 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.33 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7.10</span></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">16,956,590</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.29</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">7.20</span></td></tr></table></div><div style="margin-top:6pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary Plans</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Certain subsidiaries of the Group have adopted stock option plans. A summary of stock option activity by number of shares in these subsidiaries is presented in the following table:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:17.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.324%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Outstanding as of January 1, 2023</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Granted During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Exercised During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Expired During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Forfeited During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Deconsolidation During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Outstanding as of December 31, 2023</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">344,500</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">344,500</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,776,120</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,170,547)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(605,573)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,824,576</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,313)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(29,607)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,793,656)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:17.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.475%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding as of January 1, 2022</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Granted During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Exercised During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Expired During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Forfeited During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Deconsolidation During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding as of December 31, 2022</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">349,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">45,000 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(50,000)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">344,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,686,120 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">90,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,776,120 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sonde</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,049,004 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,049,004)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,991,637 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">490,506 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(400,000)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(65,235)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(192,332)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,824,576 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:17.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.475%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding as of January 1, 2021</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Granted During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Exercised During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Expired During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Forfeited During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Deconsolidation During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding as of December 31, 2021</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Alivio</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,888,168 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">197,398 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,373,750)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(506,260)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,205,556)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">962,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(525,000)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(87,500)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">349,500 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,309,040 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,383,080 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,000)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,686,120 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sonde</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,192,834 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(51,507)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,323)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,049,004 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,741,888 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">451,532 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(52,938)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(76,491)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(72,354)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,991,637 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The weighted-average exercise prices and remaining contractual life for the options outstanding as of December 31, 2023, were as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding at December 31, 2023</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of options</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Weighted-average exercise price</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Weighted-average contractual life outstanding</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">344,500</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.91</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3.92</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">There were no grants in 2023 under any of the subsidiary option plans. The weighted average exercise prices for the options granted for the years ended December 31, 2022 and 2021, were as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ended December 31,</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.02 </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.86 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.86 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></div></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14.94 </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">19.69 </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The weighted average exercise prices for options forfeited during the year ended December 31, 2023, were as follows: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Forfeited during the year ended December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of options</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Weighted-average exercise price</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">605,573</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.86</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">29,607</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">17.06</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The weighted average exercise prices for options exercisable as of December 31, 2023, were as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Exercisable at December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of Options</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Weighted-average exercise price</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Exercise Price Range<br/>$</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">329,500</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.99</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.02-2.36</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">There were no subsidiary options exercised during the year ended December 31, 2023.</span></div>For the years ended December 31, 2023, 2022 and 2021, the subsidiaries incurred share-based payment expense of $277, $4,711 and $6,252, respectively. 4415000 14699000 13950000 The following table provides the classification of the Group’s consolidated share-based payment expense as reflected in the Consolidated Statement of Income/(Loss):<div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Year ended December 31,</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">General and administrative</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,185</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,862 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,310 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Research and development</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,230</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,837 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,640 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,415</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,699 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,950 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 3185000 8862000 9310000 1230000 5837000 4640000 4415000 14699000 13950000 0.10 P4Y P10Y 0.10 P5Y 27384777 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSU activity for the years ended December 31, 2023, 2022 and 2021 is detailed as follows:</span></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Number of Shares/Units</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Weighted Average Grant Date Fair Value (GBP) (*)</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding (Non-vested) at January 1, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,422,582 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.46 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs Granted in Period</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,195,133 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.15 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vested</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,176,695)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.93 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(808,305)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.25 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding (Non-vested) at December 31, 2021 and January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,632,715 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.91 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs Granted in Period</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,309,883 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.76 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vested</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(696,398)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.80 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,155,420)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.67 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding (Non-vested) at December 31, 2022 and January 1, 2023</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6,090,780</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.74</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">RSUs Granted in Period</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,679,669 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.28 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vested</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(716,029)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.00 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,880,274)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.94 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding (Non-vested) at December 31, 2023</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">7,174,146</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.10</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">*    For liability awards - based on fair value at reporting date.</span></div> 3422582 2.46 2195133 2.15 1176695 2.93 808305 2.25 3632715 1.91 4309883 1.76 696398 2.80 1155420 2.67 6090780 1.74 3679669 1.28 716029 2.00 1880274 1.94 7174146 1.10 1 P3Y 1 100000 827000 402000 1637000 1131000 1540000 589000 4782000 1281000 3501000 1283000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Stock option activity for the years ended December 31, 2023, 2022 and 2021, is detailed as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Number of Options</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd Average Exercise Price (GBP)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd Average of<br/>remaining contractual<br/>term (in years)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd Average Stock Price at Exercise (GBP)</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding at January 1, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,916,086 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.81 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.38</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Granted</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,424,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.34 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exercised</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,238,187)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.70 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.63</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited and expired</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(687,781)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.53 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.19pt;font-weight:700;line-height:120%">Options Exercisable at December 31, 2021 and January 1, 2022</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,773,873 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.42 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6.50</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding at December 31, 2021 and January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,414,118 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.58 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.29</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Granted</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,881,000 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.04 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exercised</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(577,022)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.50 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.43</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited and expired</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,924,215)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.89 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.19pt;font-weight:700;line-height:120%">Options Exercisable at December 31, 2022 and January 1, 2023</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6,185,216</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.03</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6.21</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding at December 31, 2022 and January 1, 2023</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">17,793,881</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.31</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">8.03</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Granted</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,120,975 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.22 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exercised</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(534,034)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.71 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.46</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Forfeited and expired</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,424,232)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.40 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Options Exercisable at December 31, 2023</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">9,065,830</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.19</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6.01</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Outstanding at December 31, 2023</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">16,956,590</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.29</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">7.20</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td></tr></table></div> 10916086 1.81 P8Y4M17D 5424000 3.34 2238187 0.70 3.63 687781 2.53 4773873 1.42 P6Y6M 13414118 2.58 P8Y3M14D 8881000 2.04 577022 0.50 2.43 3924215 2.89 6185216 2.03 P6Y2M15D 17793881 2.31 P8Y10D 3120975 2.22 534034 1.71 2.46 3424232 2.40 9065830 2.19 P6Y3D 16956590 2.29 P7Y2M12D <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of the stock options awarded by the Group was estimated at the grant date using the Black-Scholes option valuation model, considering the terms and conditions upon which options were granted, with the following weighted-average assumptions:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">At December 31,</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Expected volatility</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">43.69</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">41.70 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">41.05 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Expected terms (in years)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6.16</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6.11</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6.16</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Risk-free interest rate</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4.04</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.13 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.06 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Expected dividend yield</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exercise price (GBP)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.22</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.04</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.34</span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Underlying stock price (GBP)</span></td><td colspan="3" style="border-bottom:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.22</span></td><td colspan="3" style="border-bottom:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.04</span></td><td colspan="3" style="border-bottom:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.34</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 0.4369 0.4170 0.4105 6.16 6.11 6.16 0.0404 0.0213 0.0106 0 0 0 2.22 2.04 3.34 2.22 2.04 3.34 1.37 1.15 1.87 3310000 8351000 6158000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For shares outstanding as of December 31, 2023, the range of exercise prices is detailed as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Range of Exercise Prices (GBP)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Options<br/>Outstanding</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd<br/>Average<br/>Exercise<br/>Price (GBP)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Wtd Average of<br/>remaining contractual<br/>term (in years)</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.01</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">439,490 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5.76</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.00 to 2.00</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,989,572 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.54 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5.64</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.00 to 3.00</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,664,028 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.25 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.55</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.00 to 4.00</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,863,500 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.33 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7.10</span></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">16,956,590</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2.29</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">7.20</span></td></tr></table></div> 0.01 439490 0 P5Y9M3D 1.00 2.00 4989572 1.54 P5Y7M20D 2.00 3.00 6664028 2.25 P8Y6M18D 3.00 4.00 4863500 3.33 P7Y1M6D 16956590 2.29 P7Y2M12D A summary of stock option activity by number of shares in these subsidiaries is presented in the following table:<div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:17.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.324%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Outstanding as of January 1, 2023</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Granted During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Exercised During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Expired During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Forfeited During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Deconsolidation During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Outstanding as of December 31, 2023</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">344,500</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">344,500</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,776,120</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,170,547)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(605,573)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,824,576</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,313)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(29,607)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,793,656)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:17.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.475%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding as of January 1, 2022</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Granted During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Exercised During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Expired During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Forfeited During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Deconsolidation During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding as of December 31, 2022</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">349,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">45,000 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(50,000)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">344,500 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,686,120 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">90,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,776,120 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sonde</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,049,004 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,049,004)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,991,637 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">490,506 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(400,000)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(65,235)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(192,332)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,824,576 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:17.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.475%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding as of January 1, 2021</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Granted During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Exercised During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Expired During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Forfeited During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Deconsolidation During the Year</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding as of December 31, 2021</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Alivio</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,888,168 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">197,398 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,373,750)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(506,260)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,205,556)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">962,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(525,000)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(87,500)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">349,500 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,309,040 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,383,080 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,000)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,686,120 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sonde</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,192,834 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(51,507)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,323)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,049,004 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,741,888 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">451,532 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(52,938)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(76,491)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(72,354)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,991,637 </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 344500 0 0 0 0 0 344500 2776120 0 0 2170547 605573 0 0 1824576 0 0 1313 29607 1793656 0 349500 45000 0 50000 0 0 344500 2686120 90000 0 0 0 0 2776120 2049004 0 0 0 0 2049004 0 1991637 490506 400000 65235 192332 0 1824576 3888168 197398 2373750 506260 1205556 0 0 962000 0 525000 87500 0 0 349500 1309040 1383080 0 6000 0 0 2686120 2192834 0 0 51507 92323 0 2049004 1741888 451532 52938 76491 72354 0 1991637 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The weighted-average exercise prices and remaining contractual life for the options outstanding as of December 31, 2023, were as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Outstanding at December 31, 2023</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of options</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Weighted-average exercise price</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Weighted-average contractual life outstanding</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">344,500</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.91</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3.92</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 344500 1.91 P3Y11M1D The weighted average exercise prices for the options granted for the years ended December 31, 2022 and 2021, were as follows:<div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ended December 31,</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.02 </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.86 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.86 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></div></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14.94 </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">19.69 </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 0.02 0 1.86 1.86 14.94 19.69 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The weighted average exercise prices for options forfeited during the year ended December 31, 2023, were as follows: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Forfeited during the year ended December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of options</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Weighted-average exercise price</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">605,573</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.86</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">29,607</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">17.06</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 605573 1.86 29607 17.06 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The weighted average exercise prices for options exercisable as of December 31, 2023, were as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.844%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Exercisable at December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of Options</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Weighted-average exercise price</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Exercise Price Range<br/>$</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">329,500</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.99</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #494949;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.02-2.36</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 329500 1.99 0.02 2.36 0 277000 4711000 6252000 Finance Income/(Costs), net <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table shows the breakdown of finance income and costs:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ended December 31,</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Finance income</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest income from financial assets</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">16,012</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,799 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">214 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total finance income</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">16,012</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,799 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">214 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Finance costs</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contractual interest expense on notes payable</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,422)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(212)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,031)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest expense on other borrowings</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(363)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,759)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,502)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest expense on lease liability</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,544)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,982)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,181)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on foreign currency exchange</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(94)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(56)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total finance cost – contractual</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(3,424)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,939)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(4,771)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) from change in fair value of warrant liability</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">33</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,740 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,419 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) from change in fair value of preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,617</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">130,825 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,362 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) from change in fair value of convertible debt</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(502)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(175)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total finance income/(costs) – fair value accounting</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,650</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">137,063 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,606 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total finance costs - non cash interest expense related to sale of future royalties</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(10,159)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Finance income/(costs), net</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,078</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">138,924 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,050 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> Finance Income/(Costs), net <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table shows the breakdown of finance income and costs:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the years ended December 31,</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Finance income</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest income from financial assets</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">16,012</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,799 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">214 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total finance income</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">16,012</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,799 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">214 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Finance costs</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Contractual interest expense on notes payable</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,422)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(212)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,031)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest expense on other borrowings</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(363)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,759)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,502)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest expense on lease liability</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,544)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,982)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,181)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on foreign currency exchange</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(94)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(56)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total finance cost – contractual</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(3,424)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,939)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(4,771)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) from change in fair value of warrant liability</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">33</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,740 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,419 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) from change in fair value of preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,617</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">130,825 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,362 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) from change in fair value of convertible debt</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(502)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(175)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total finance income/(costs) – fair value accounting</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,650</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">137,063 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,606 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total finance costs - non cash interest expense related to sale of future royalties</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(10,159)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Finance income/(costs), net</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,078</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">138,924 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,050 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 16012000 5799000 214000 16012000 5799000 214000 1422000 212000 1031000 363000 1759000 1502000 1544000 1982000 2181000 -94000 14000 -56000 3424000 3939000 4771000 33000 6740000 1419000 2617000 130825000 8362000 0 -502000 -175000 2650000 137063000 9606000 10159000 0 0 5078000 138924000 5050000 Earnings/(Loss) per Share <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Basic earnings/(loss) per share is calculated by dividing the Group's net income or loss for the year attributable to ordinary shareholders by the weighted average number of ordinary shares outstanding, net of treasury shares.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Diluted EPS is calculated by dividing the Group's net income or loss for the year by the weighted average number of ordinary shares outstanding, net of treasury shares, plus the weighted average number of ordinary shares that would be issued at conversion of all the dilutive potential ordinary shares into ordinary shares. Dilutive effects arise from equity-settled shares from the Group's share-based plans. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For the years ended December 31, 2023, 2022 and 2021, the Group incurred a net loss and therefore all outstanding potential securities were considered anti-dilutive. The amount of potential securities that were excluded from the diluted calculation amounted to 1,509,900, 3,134,131 and 6,553,905 shares, respectively. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Earnings/(Loss) Attributable to Owners of the Group:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:28.596%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Diluted $</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted $</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted $</span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/(loss) for the year, attributable to the owners of the Group</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(65,697)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(65,697)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(50,354)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(50,354)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(60,558)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(60,558)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Weighted-Average Number of Ordinary Shares:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:28.596%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Basic</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Diluted</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.1pt;font-weight:400;line-height:120%">Issued ordinary shares at January 1,</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">278,566,306</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">278,566,306</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">287,796,585 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">287,796,585 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">285,885,025 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">285,885,025 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Effect of shares issued &amp; treasury shares purchased</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,263,773)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,263,773)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,037,150)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,037,150)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">705,958 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">705,958 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Weighted average number of ordinary shares at December 31,</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">276,302,533</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">276,302,533</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">284,759,435 </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">284,759,435 </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">286,590,983 </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">286,590,983 </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Earnings/(Loss) per Share:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:28.596%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Diluted $</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted $</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted $</span></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Basic and diluted earnings/(loss) per share</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(0.24)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(0.24)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.18)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.18)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.21)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.21)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 1509900 3134131 6553905 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Earnings/(Loss) Attributable to Owners of the Group:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:28.596%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Diluted $</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted $</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted $</span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/(loss) for the year, attributable to the owners of the Group</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(65,697)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(65,697)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(50,354)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(50,354)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(60,558)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(60,558)</span></td><td style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> -65697000 -65697000 -50354000 -50354000 -60558000 -60558000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Weighted-Average Number of Ordinary Shares:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:28.596%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Basic</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Diluted</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.1pt;font-weight:400;line-height:120%">Issued ordinary shares at January 1,</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">278,566,306</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">278,566,306</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">287,796,585 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">287,796,585 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">285,885,025 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">285,885,025 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Effect of shares issued &amp; treasury shares purchased</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,263,773)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,263,773)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,037,150)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,037,150)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">705,958 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">705,958 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Weighted average number of ordinary shares at December 31,</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">276,302,533</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">276,302,533</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">284,759,435 </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">284,759,435 </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">286,590,983 </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">286,590,983 </span></td><td style="border-bottom:0.5pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 278566306 278566306 287796585 287796585 285885025 285885025 2263773 2263773 3037150 3037150 -705958 -705958 276302533 276302533 284759435 284759435 286590983 286590983 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Earnings/(Loss) per Share:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:28.596%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Diluted $</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted $</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Basic $</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Diluted $</span></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Basic and diluted earnings/(loss) per share</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(0.24)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(0.24)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.18)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.18)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.21)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.21)</span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> -0.24 -0.24 -0.18 -0.18 -0.21 -0.21 Property and Equipment<div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.809%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Cost</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Laboratory and Manufacturing Equipment</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Furniture and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Fixtures</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Computer Equipment and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Software</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Leasehold Improvements</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Construction in</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">process</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,733 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,452 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,329 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">18,485 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,116 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">41,115 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions, net of transfers</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">390 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">412 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,362 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,176 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disposals</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(118)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(77)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(195)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(58)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(58)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reclassifications</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,336 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">58 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">137 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,067 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,598)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,341 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,510 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,419 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">23,964 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,803 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">43,037 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions, net of transfers</span></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">87 </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">87 </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disposals/Impairment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,886)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(137)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,023)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(5,092)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(438)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(365)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,799)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,871)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(17,565)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reclassifications</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(18)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(18)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,363</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,072</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">917</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">15,165</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">22,518</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.809%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Accumulated depreciation and impairment loss</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Laboratory and Manufacturing Equipment</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Furniture and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Fixtures</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Computer Equipment and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Software</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Leasehold Improvements</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Construction in</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">process</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(5,686)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(663)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,190)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,806)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(14,344)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,082)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(212)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(107)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,444)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(5,845)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disposals</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">53 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">53 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(7,711)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(875)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,244)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(10,250)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(20,080)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation</span></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(892)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(162)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(45)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,856)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,955)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disposals</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">543 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">38 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">581 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,917 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">357 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,858 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,472 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(4,142)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(698)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(894)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(7,248)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(12,982)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.809%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Property and Equipment, net</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Laboratory and Manufacturing Equipment</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Furniture and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Fixtures</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Computer Equipment and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Software</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Leasehold Improvements</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Construction in</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">process</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,630 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">635 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">174 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,714 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,803 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22,957 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,221</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">375</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">23</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">7,917</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">9,536</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation of property and equipment is included in the general and administrative expenses and research and development expenses in the Consolidated Statement of Comprehensive Income/(Loss). The Group recorded depreciation expense of $2,955, $5,845 and $4,347 for the years ended December 31, 2023, 2022 and 2021, respectively.</span></div> <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.809%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Cost</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Laboratory and Manufacturing Equipment</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Furniture and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Fixtures</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Computer Equipment and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Software</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Leasehold Improvements</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Construction in</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">process</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,733 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,452 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,329 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">18,485 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,116 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">41,115 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions, net of transfers</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">390 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">412 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,362 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,176 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disposals</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(118)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(77)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(195)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(58)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(58)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reclassifications</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,336 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">58 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">137 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,067 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,598)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,341 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,510 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,419 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">23,964 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,803 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">43,037 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions, net of transfers</span></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">87 </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">87 </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disposals/Impairment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,886)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(137)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,023)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(5,092)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(438)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(365)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,799)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,871)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(17,565)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reclassifications</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(18)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(18)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,363</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,072</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">917</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">15,165</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">22,518</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 11733000 1452000 1329000 18485000 8116000 41115000 390000 0 11000 412000 1362000 2176000 118000 0 0 0 77000 195000 0 0 58000 0 0 58000 1336000 58000 137000 5067000 -6598000 0 13341000 1510000 1419000 23964000 2803000 43037000 0 0 0 0 87000 87000 2886000 0 137000 0 0 3023000 5092000 438000 365000 8799000 2871000 17565000 0 0 0 0 -18000 -18000 5363000 1072000 917000 15165000 1000 22518000 <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.809%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Accumulated depreciation and impairment loss</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Laboratory and Manufacturing Equipment</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Furniture and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Fixtures</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Computer Equipment and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Software</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Leasehold Improvements</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Construction in</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">process</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(5,686)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(663)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,190)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,806)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(14,344)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,082)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(212)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(107)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,444)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(5,845)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disposals</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">53 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">53 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(7,711)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(875)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,244)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(10,250)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(20,080)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation</span></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(892)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(162)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(45)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,856)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,955)</span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Disposals</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">543 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">38 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">581 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,917 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">357 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,858 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9,472 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(4,142)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(698)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(894)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(7,248)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(12,982)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> -5686000 -663000 -1190000 -6806000 0 -14344000 2082000 212000 107000 3444000 0 5845000 -57000 0 0 0 0 -57000 0 0 -53000 0 0 -53000 -7711000 -875000 -1244000 -10250000 0 -20080000 892000 162000 45000 1856000 0 2955000 -543000 0 -38000 0 0 -581000 -3917000 -339000 -357000 -4858000 0 -9472000 -4142000 -698000 -894000 -7248000 0 -12982000 <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.809%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Property and Equipment, net</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Laboratory and Manufacturing Equipment</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Furniture and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Fixtures</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Computer Equipment and</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Software</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Leasehold Improvements</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Construction in</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">process</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,630 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">635 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">174 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,714 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,803 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22,957 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,221</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">375</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">23</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">7,917</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">9,536</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 5630000 635000 174000 13714000 2803000 22957000 1221000 375000 23000 7917000 1000 9536000 2955000 5845000 4347000 Intangible Assets<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Intangible assets consist of licenses of intellectual property acquired by the Group through various agreements with third parties and are recorded at the value of the consideration transferred. Information regarding the cost and accumulated amortization of intangible assets is as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Cost</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Licenses</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">990 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(163)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(21)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">831 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions</span></td><td colspan="2" style="border-top:0.5pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200 </span></td><td style="border-top:0.5pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(105)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(19)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">906</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Accumulated amortization</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Licenses</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amortization</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amortization</span></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Intangible assets, net</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Licenses</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">831 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">906</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Substantially all the intangible asset licenses represent in-process-research-and-development assets since they are still being developed and not ready for their intended use. As such, these assets are not amortized but tested for impairment annually. </span></div><div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2023, the Group wrote off two of its research intangible assets for which research was ceased in the amount of $105.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2023, Vedanta , Inc. was deconsolidated and as such, $19 net in intangible assets were derecognized.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31,2022, the Group wrote off one of its research intangible assets for which research was ceased in the amount of $163.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2022, Sonde Health, Inc. was deconsolidated and as such, $18 net intangible assets were derecognized.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group tested all intangible assets for impairment as of the balance sheet date and concluded that none of such assets were impaired. </span></div>The Group had negligible amortization expense for the years ended December 31, 2022 and 2021 and no amortization expense for the year ended December 31, 2023. Information regarding the cost and accumulated amortization of intangible assets is as follows:<div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Cost</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Licenses</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">990 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(163)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(21)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">831 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions</span></td><td colspan="2" style="border-top:0.5pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200 </span></td><td style="border-top:0.5pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Impairment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(105)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiaries</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(19)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">906</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 990000 25000 163000 -21000 831000 200000 105000 -19000 906000 <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Accumulated amortization</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Licenses</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amortization</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amortization</span></td><td colspan="2" style="border-top:0.5pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.5pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> -3000 1000 4000 0 0 0 0 <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Intangible assets, net</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Licenses</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">831 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">906</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 831000 906000 2 105000 19000 163000 18000 Other Financial Assets <div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other financial assets consist primarily of restricted cash reserved as collateral against a letter of credit with a bank that is issued for the benefit of a landlord in lieu of a security deposit for office space leased by the Group. The restricted cash was $1,628 and $2,124 as of December 31, 2023 and 2022, respectively.</span></div> 1628000 2124000 Equity<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total equity for the Group as of December 31, 2023, and 2022, was as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:17pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">December 31, 2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">December 31, 2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:11pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Equity</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share capital, £0.01 par value, issued and paid 271,853,731 and 278,566,306 as of December 31, 2023 and 2022, respectively</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,461</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,455 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share premium</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">290,262</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">289,624 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Treasury shares, 17,614,428 and 10,595,347 as of December 31, 2023 and 2022, respectively</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(44,626)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(26,492)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Merger Reserve</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">138,506</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">138,506 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Translation reserve</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">182</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">89 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other reserves</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(9,538)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(14,478)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Retained earnings/(accumulated deficit)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">83,820</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149,516 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity attributable to owners of the Group</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">464,066</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">542,220 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-controlling interests</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(5,835)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,369 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total equity</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">458,232</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">547,589 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Changes in share capital and share premium relate primarily to incentive options exercises during the period.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Shareholders are entitled to vote on all matters submitted to shareholders for a vote. Each ordinary share is entitled to one vote and is entitled to receive dividends when and if declared by the Group’s Directors. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On June 18, 2015, the Group acquired the entire issued share capital of PureTech LLC in return for 159,648,387 ordinary shares. This was accounted for as a common control transaction at cost. It was deemed that the share capital was issued in line with movements in share capital as shown prior to the transaction taking place. In addition, the merger reserve records amounts previously recorded as share premium.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other reserves comprise the cumulative credit to share-based payment reserves corresponding to share-based payment expenses recognized through Consolidated Statement of Comprehensive Income/(Loss), settlements of vested stock awards as well as other additions that flow directly through equity such as the excess or deficit from changes in ownership of subsidiaries while control is maintained by the Group.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On May 9, 2022, the Group announced the commencement of a $50,000 share repurchase program (the "Program") of its ordinary shares of one pence each (the “Ordinary Shares”). The Group executed the Program in two equal tranches. The Group entered into an irrevocable non-discretionary instruction with Jefferies International Limited (“Jefferies”) in relation to the purchase by Jefferies of the Ordinary Shares for an aggregate consideration (excluding expenses) of no greater than $25,000 for each tranche, and the simultaneous on-sale of such Ordinary Shares by Jefferies to the Group, subject to certain volume and price restrictions. Jefferies made its trading decisions in relation to the Ordinary Shares independently of, and uninfluenced by, the Group. Purchases could continue during any close period to which the Group was subject. The instruction to Jeffries could be amended or withdrawn so long as the Group was not in a close period or otherwise in possession of inside information.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Any purchases of the Ordinary Shares under the Program were carried out on the London Stock Exchange and could be carried out on any other UK recognized investment exchange in accordance with pre-set parameters and subject to limits prescribed by the Group’s general authority to repurchase the Ordinary Shares granted by its shareholders at its annual general meeting on May 27, 2021, and relevant Rules and Regulations. All Ordinary Shares repurchased under the Program are held in treasury and re-issued for settlement of share-based awards. As of December 31, 2023, the Group had repurchased an aggregate of 18,278,873 Ordinary Shares under the share repurchase program with 7,683,526 shares repurchased in 2023. The Program was completed during the month ended February 2024.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023, the Group’s issued share capital was 289,468,159 shares, including 17,614,428 shares repurchased under the Program and were held by the Group in treasury. The Group does not have a limited amount of authorized share capital.</span></div> <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total equity for the Group as of December 31, 2023, and 2022, was as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:17pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">December 31, 2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">December 31, 2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:11pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Equity</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share capital, £0.01 par value, issued and paid 271,853,731 and 278,566,306 as of December 31, 2023 and 2022, respectively</span></div></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,461</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,455 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share premium</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">290,262</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">289,624 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Treasury shares, 17,614,428 and 10,595,347 as of December 31, 2023 and 2022, respectively</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(44,626)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(26,492)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Merger Reserve</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">138,506</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">138,506 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Translation reserve</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">182</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">89 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other reserves</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(9,538)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(14,478)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Retained earnings/(accumulated deficit)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">83,820</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149,516 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity attributable to owners of the Group</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">464,066</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">542,220 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-controlling interests</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(5,835)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,369 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total equity</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">458,232</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">547,589 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div> 0.01 0.01 271853731 278566306 5461000 5455000 290262000 289624000 17614428 10595347 44626000 26492000 138506000 138506000 182000 89000 -9538000 -14478000 83820000 149516000 464066000 542220000 -5835000 5369000 458232000 547589000 1 159648387 50000000 1 2 25000000 18278873 7683526 289468159 17614428 Subsidiary Preferred Shares <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Preferred shares issued by subsidiaries often contain redemption and conversion features that are assessed under IFRS 9 in conjunction with the host preferred share instrument. This balance represents subsidiary preferred shares issued to third parties. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The subsidiary preferred shares are redeemable upon the occurrence of a contingent event, other than full liquidation of the Group, that is not considered to be within the control of the Group. Therefore these subsidiary preferred shares are classified as liabilities. These liabilities are measured at fair value through profit and loss. The preferred shares are convertible into ordinary shares of the subsidiaries at the option of the holders and are mandatorily convertible into ordinary shares under certain circumstances. Under certain scenarios, the number of ordinary shares receivable on conversion will change and therefore, the number of shares that will be issued is not fixed. As such the conversion feature is considered to be an embedded derivative that normally would require bifurcation. However, since the preferred share liabilities are measured at fair value through profit and loss, as mentioned above, no bifurcation is required. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The preferred shares are entitled to vote with holders of common shares on an as converted basis.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of all subsidiary preferred shares as of December 31, 2023 and December 31, 2022, is as follows: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31,</span></div></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">169 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">350 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26,820 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total subsidiary preferred share balance</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As is customary, in the event of any voluntary or involuntary liquidation, dissolution or winding up of a subsidiary, the holders of subsidiary preferred shares which are outstanding shall be entitled to be paid out of the assets of the subsidiary available for distribution to shareholders and before any payment shall be made to holders of ordinary shares. A merger, acquisition, sale of voting control or other transaction of a subsidiary in which the shareholders of the subsidiary immediately before the transaction do not own a majority of the outstanding shares of the surviving company shall be deemed to be a liquidation event. Additionally, a sale, lease, transfer or other disposition of all or substantially all of the assets of the subsidiary shall also be deemed a liquidation event.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023 and December 31, 2022, the minimum liquidation preference reflecting the amounts that would be payable to the subsidiary preferred holders upon a liquidation event of the subsidiaries, is as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31,</span></div></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,216</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,216 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6,405</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,405 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149,568 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total minimum liquidation preference</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">8,621</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">158,189 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For the years ended December 31, 2023 and 2022, the Group recognized the following changes in the value of subsidiary preferred shares:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">174,017 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Decrease in value of preferred shares measured at fair value – finance costs (income)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(130,825)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary - (Sonde)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(15,853)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Decrease in value of preferred shares measured at fair value – finance costs (income)</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,617)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary – (Vedanta)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24,554)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#183964;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of all subsidiary preferred shares as of December 31, 2023 and December 31, 2022, is as follows: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31,</span></div></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">169 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">350 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26,820 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total subsidiary preferred share balance</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div> 169000 169000 0 350000 0 26820000 169000 27339000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023 and December 31, 2022, the minimum liquidation preference reflecting the amounts that would be payable to the subsidiary preferred holders upon a liquidation event of the subsidiaries, is as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31,</span></div></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,216</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,216 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Follica</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6,405</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">6,405 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149,568 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total minimum liquidation preference</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">8,621</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">158,189 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div> 2216000 2216000 6405000 6405000 0 149568000 8621000 158189000 <div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For the years ended December 31, 2023 and 2022, the Group recognized the following changes in the value of subsidiary preferred shares:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">174,017 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Decrease in value of preferred shares measured at fair value – finance costs (income)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(130,825)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary - (Sonde)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(15,853)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Decrease in value of preferred shares measured at fair value – finance costs (income)</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,617)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary – (Vedanta)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24,554)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#183964;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 174017000 -130825000 15853000 27339000 -2617000 24554000 169000 Sale of Future Royalties Liability<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On March 4, 2011, the Group entered into a license agreement with Karuna Therapeutics, Inc. (“Karuna”) according to which the Group granted Karuna an exclusive license to research, develop and sell KarXT in exchange for a royalty on annual net sales, development and regulatory milestones and a fixed portion of sublicensing income, if any (hereinafter “License Agreement”).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On March 22, 2023, the Group signed an agreement with Royalty Pharma (hereinafter "Royalty Purchase Agreement"), according to which the Group sold Royalty Pharma a partial right to receive royalty payments made by Karuna in respect of net sales of KarXT, if and when received. According to the Royalty Purchase Agreement, all royalties due to the Group under the License Agreement will be paid to Royalty Pharma up until an annual threshold of $60,000, while all royalties above such annual threshold in a given year will be split 33% to Royalty Pharma and 67% to the Group. Under the terms of the Royalty Purchase Agreement, the Group received a non-refundable initial payment of $100,000 at the execution of the Royalty Purchase Agreement and is eligible to receive additional payments in the aggregate of up to an additional $400,000 based on the achievement of certain regulatory and commercial milestones.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group continues to hold the rights under the License Agreement and has a contractual obligation to deliver cash to Royalty Pharma for a portion of the royalties it receives. Therefore, the Group will continue to account for any royalties and regulatory milestones due to the Group under the License Agreement as revenue in its Consolidated Statement of Comprehensive Income/(Loss) and record the proceeds from the Royalty Purchase Agreement as a financial liability on its Consolidated Statement of Financial Position. In determining the appropriate accounting treatment for the Royalty Purchase Agreement, management applied significant judgement.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The acquisition of Karuna by Bristol Meyers Squibb (NYSE: BMY), which closed on March 18, 2024, had no impact on the Group's rights or obligations under the License Agreement or Royalty Purchase Agreement, each of which remains in full force and effect.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In order to determine the amortized cost of the sale of future royalties liability, management is required to estimate the total amount of future receipts from and payments to Royalty Pharma under the Royalty Purchase Agreement over the life of the agreement. The $100,000 liability, recorded at execution of the Royalty Purchase Agreement, will be accreted to the total of these receipts and payments as interest expense over the life of the Royalty Purchase Agreement. These estimates contain assumptions that impact both the amortized cost of the liability and the interest expense that will be recognized in future periods. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additional proceeds received from Royalty Pharma will increase the Group’s financial liability. As royalty payments are made to Royalty Pharma, the balance of the liability will be effectively repaid over the life of the Royalty Purchase Agreement. The estimated timing and amount of royalty payments to and proceeds from Royalty Pharma are likely to change over the life of the Royalty Purchase Agreement. A significant increase or decrease in estimated royalty payments, or a significant shift in the timing of cash flows, will materially impact the sale of future royalties liability, interest expense and the time period for repayment. The Group will periodically assess the expected payments to, or proceeds from, Royalty Pharma, and any such changes in amount or timing of cash flows will require the Group to re-calculate the amortized cost of the sale of future royalties liability as the present value of the estimated future cash flows from the Royalty Purchase Agreement that are discounted at the liability’s original effective interest rate. The adjustment is recognized immediately in profit or loss as income or expense. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following shows the activity in respect of the sale of future royalties liability:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Sale of future royalties liability</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2023</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amounts received at closing</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non cash interest expense recognized</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,159 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">110,159</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 60000000 0.33 0.67 100000000 400000000 100000000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following shows the activity in respect of the sale of future royalties liability:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Sale of future royalties liability</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance as of January 1, 2023</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amounts received at closing</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">100,000 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non cash interest expense recognized</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,159 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">110,159</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 0 100000000 10159000 110159000 Financial Instruments <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s financial instruments consist of financial assets in the form of notes, convertible notes and investment in shares, and financial liabilities, including preferred shares. Many of these financial instruments are presented at fair value, with changes in fair value recorded through profit and loss.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Fair Value Process</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For financial instruments measured at fair value under IFRS 9, the change in the fair value is reflected through profit and loss. Using the guidance in IFRS 13, the total business enterprise value and allocable equity of each entity being valued can be determined using a market backsolve approach through a recent arm’s length financing round (or a future probable arm's length transaction), market/asset probability-weighted expected return method ("PWERM") approach, discounted cash flow approach, or hybrid approaches. The approaches, in order of strongest fair value evidence, are detailed as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:21.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:76.779%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Valuation Method</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Description</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Market – Backsolve</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The market backsolve approach benchmarks the original issue price (OIP) of the company’s latest funding transaction as current value.</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Market/Asset – PWERM</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Under a PWERM, the company value is based upon the probability-weighted present value of expected future investment returns, considering each of the possible future outcomes available to the enterprise. Possible future outcomes can include IPO scenarios, potential SPAC transactions, merger and acquisition transactions as well as other similar exit transactions of the investee.</span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">I</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">ncome Based – DCF</span></div></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The income approach is used to estimate fair value based on the income streams, such as cash flows or earnings, that an asset or business can be expected to generate.</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">At each measurement date, investments held at fair value (that are not publicly traded) as well as the fair value of preferred share liabilities, including embedded conversion rights that are not bifurcated, were determined using the following allocation methods: option pricing model (“OPM”), PWERM, or hybrid allocation framework. The methods are detailed as follows:</span></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:21.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:76.779%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Allocation Method</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Description</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">OPM</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The OPM model treats preferred stock as call options on the enterprise’s equity value, with exercise prices based on the liquidation preferences of the preferred stock.</span><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PWERM</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Under a PWERM, share value is based upon the probability-weighted present value of expected future investment returns, considering each of the possible future outcomes available to the enterprise, as well as the rights of each share class. </span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Hybrid</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The hybrid method is a combination of the PWERM and OPM. Under the hybrid method, multiple liquidity scenarios are weighted based on the probability of the scenario's occurrence, similar to the PWERM, while also utilizing the OPM to estimate the allocation of value in one or more of the scenarios. </span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Valuation policies and procedures are regularly monitored by the Group. Fair value measurements, including those categorized within Level 3, are prepared and reviewed for reasonableness and compliance with the fair value measurements guidance under IFRS accounting standards. The Group measures fair value using the following fair value hierarchy that reflects the significance of the inputs used in making the measurements:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:21.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:76.779%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Fair Value<br/>Hierarchy Level</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Description</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Level 1</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Inputs that are quoted market prices (unadjusted) in active markets for identical instruments.</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Level 2</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Inputs other than quoted prices included within Level 1 that are observable either directly (i.e. as prices) or indirectly (i.e. derived from prices). </span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Level 3</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Inputs that are unobservable. This category includes all instruments for which the valuation technique includes inputs not based on observable data and the unobservable inputs have a significant effect on the instruments' valuation. </span></div></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Whilst the Group considers the methodologies and assumptions adopted in fair value measurements as supportable and reasonable, because of the inherent uncertainty of valuation, those estimated values may differ significantly from the values that would have been used had a ready market for the investment existed.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary Preferred Shares Liability and Subsidiary Convertible Notes</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes the changes in the Group’s subsidiary preferred shares and convertible notes liabilities measured at fair value, which were categorized as Level 3 in the fair value hierarchy:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"><div style="margin-bottom:10pt"><span><br/></span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Subsidiary Preferred Shares<br/>$</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Subsidiary Convertible<br/>Notes<br/>$</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">118,972 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25,000 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Value at issuance</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">37,610 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,215 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Conversion to subsidiary preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25,797 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(25,797)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest - contractual</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,362)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">175 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at December 31, 2021 and January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">174,017 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,461 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Value at issuance</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">393 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest - contractual</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation - Sonde</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(15,853)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,403)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(130,825)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">502 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at December 31, 2022 and January 1, 2023</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in fair value</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,617)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation - Vedanta</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24,554)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The change in fair value of preferred shares and convertible notes liabilities are recorded in finance income/(costs) – fair value accounting in the Consolidated Statement of Comprehensive Income/(Loss).</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments Held at Fair Value</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Karuna, Vor and Akili Valuation</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Karuna (Nasdaq: KRTX), Vor (Nasdaq: VOR), Akili (Nasdaq: AKLI) and additional immaterial investments are listed entities on an active exchange, and as such, the fair value as of December 31, 2023, was calculated utilizing the quoted common share price which is categorized as Level 1 in the fair value hierarchy. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-style:italic;font-weight:400;line-height:120%">Vedanta and Sonde</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023, the Group accounts for the following investments under IFRS 9 as investments held at fair value with changes in fair value through the profit and loss: Sonde preferred A-2 and B shares and Vedanta convertible preferred shares (subsequent to the date of deconsolidation). The valuation of the aforementioned investments is categorized as Level 3 in the fair value hierarchy due to the use of significant unobservable inputs to value such assets. During the year ended December 31, 2023, the Group recorded such investments at fair value and recognized a loss of $7,298 for the change in fair value of the investments. In addition, the Group determined that the fair value of its investment in the Gelesis 2023 Warrants was $0 as Gelesis ceased operations in October 2023.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes the changes in all the Group’s investments held at fair value, which were categorized as Level 3 in the fair value hierarchy:</span></div><div style="margin-bottom:5.25pt;text-align:justify"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">206,892 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash purchase of Vor preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">500 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reclassification of Vor from level 3 to level 1</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(33,365)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on change in fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">65,505 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at December 31, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">239,533 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of Sonde</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,168 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis Earn-out Shares received in the SPAC exchange</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,214 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exchange of Gelesis preferred shares to Gelesis common shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,303)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reclassification of Akili to level 1 investment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(128,764)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on change in fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(31,253)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">12,593 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of Vedanta - new investment in Vedanta preferred shares</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">20,456 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Gelesis 2023 Warrants</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,121 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on changes in fair value</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(9,299)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">24,872</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The change in fair value of investments held at fair value is recorded in gain/(loss) on investments held at fair value in the Consolidated Statement of Comprehensive Income/(Loss).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">At December 31, 2023, the Group’s material investments held at fair value categorized as Level 3 in the fair value hierarchy include the preferred shares of Sonde and Vedanta, with fair value of $10,408 and $14,153, respectively. The significant unobservable inputs used at December 31, 2023 in the fair value measurement of these investments and the sensitivity of the fair value measurements for these investments to changes to these significant unobservable inputs are summarized in the table below. </span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:47.536%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.022%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31, 2023</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment (Sonde) Measured through </span></div><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Market Backsolve &amp; OPM</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Unobservable Inputs</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Input Value </span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Sensitivity Range</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Investment Fair Value Increase/(Decrease)</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity Value</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">53,242</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-5 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(464)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+5%</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">463 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Time to Liquidity</span></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:right;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.00</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-6 Months</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">39 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+ 6 Months</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(42)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Volatility</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">60 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-10 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">19</span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+10%</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(35)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:47.536%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.022%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31, 2023</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment (Vedanta) Measured through Market Backsolve that Leverages a Monte Carlo Simulation</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Unobservable Inputs</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Input Value </span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Sensitivity Range</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment Fair Value Increase/(Decrease)</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity Value</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">127,883</span></td><td colspan="2" style="border-top:0.25pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-5 </span></td><td style="border-top:0.25pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,416)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+5%</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,069 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Time to Liquidity</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.23</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">- 6 Months</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,907)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+ 6 Months</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,261 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Volatility</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">120 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-10 </span></td><td style="border-top:0.25pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(954)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #001544;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+10%</span></td><td colspan="2" style="border-bottom:0.25pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">474 </span></td><td style="border-bottom:0.25pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments in Notes from Associates</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2022, the investment in notes from associates was $16,501 and represents investments the Group made in convertible promissory notes of Gelesis. During the year ended December 31, 2023, the Group invested $10,729 in convertible promissory notes of Gelesis and $5,000 in a convertible note of Vedanta. The Group recorded a loss of $27,630 for the change in fair value of the notes from associates in the gain/(loss) on investments in notes from associates within the Consolidated Statement of Comprehensive Income/Loss. The loss was driven by a reduction in the fair value of the Gelesis convertible promissory notes of $27,230 as Gelesis filed for bankruptcy in October 2023 and a change in the fair value of the Vedanata convertible note of $400. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The convertible debt issued by Vedanta was valued using a market backsolve approach that leverages a Monte Carlo simulation. The significant unobservable inputs categorized as Level 3 in the fair value hierarchy used at December 31, 2023, in the fair value measurement of the convertible debt are the same as the inputs disclosed above for Vedanta preferred shares. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Fair Value Measurement and Classification</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of financial instruments by category as of December 31, 2023 and 2022:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.960%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:9.657%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="21" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Carrying Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="12" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Fair Value</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Financial Assets<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Financial Liabilities<br/>$</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Level 1<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Level 2<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Level 3<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Total<br/>$</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Financial assets</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:5.52pt;font-weight:700;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">:</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Money Markets</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1,2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">156,705</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">156,705</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">156,705</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in notes from associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,600</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,600</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,600</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">317,841</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">292,970</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">24,872</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">317,841</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total financial assets</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">479,146</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">449,675</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">29,472</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">479,146</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Financial liabilities:</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based liability awards</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,782</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,782</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,782</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total financial liabilities</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,951</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,951</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,951</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    Issued by a diverse group of corporations, largely consisting of financial institutions, virtually all of which are investment grade.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Included within cash and cash equivalents.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">3. Excluded from the table above are short-term investments of $136,062 that are classified at amortized cost as of December 31, 2023. The cost of these short-term investments approximates current fair value. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has a number of financial instruments that are not measured at fair value in the Consolidated Statement of Financial Position. For these instruments the fair values are not materially different from their carrying amounts.</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.203%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="21" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td></tr><tr><td colspan="3" style="padding:0 1pt"><div style="margin-bottom:10pt"><span><br/></span></div></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Carrying Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="12" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Fair Value</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Financial Assets<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Financial Liabilities<br/>$</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Level 1<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Level 2<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Level 3<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total<br/>$</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial assets:</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Money Markets</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1,2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">95,249 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">95,249 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">95,249 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term investments</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Note from associate</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">16,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">16,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">16,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">251,892 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">239,299 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">12,593 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">251,892 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other receivables</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">3</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total financial assets</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">575,738 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">534,777 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,094 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">575,738 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial liabilities:</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary warrant liability</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary notes payable</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,097 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">248 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based liability awards</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,932 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,396 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,537 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,932 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total financial liabilities</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">35,664 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,396 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,097 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,171 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">35,664 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    Issued by a diverse group of corporations, largely consisting of financial institutions, virtually all of which are investment grade.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Included within cash and cash equivalents.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">3 Outstanding receivables are owed primarily by government agencies and large corporations, virtually all of which are investment grade.</span></div> The approaches, in order of strongest fair value evidence, are detailed as follows:<div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:21.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:76.779%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Valuation Method</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Description</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Market – Backsolve</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The market backsolve approach benchmarks the original issue price (OIP) of the company’s latest funding transaction as current value.</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Market/Asset – PWERM</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Under a PWERM, the company value is based upon the probability-weighted present value of expected future investment returns, considering each of the possible future outcomes available to the enterprise. Possible future outcomes can include IPO scenarios, potential SPAC transactions, merger and acquisition transactions as well as other similar exit transactions of the investee.</span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">I</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">ncome Based – DCF</span></div></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The income approach is used to estimate fair value based on the income streams, such as cash flows or earnings, that an asset or business can be expected to generate.</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div>The methods are detailed as follows:<div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:21.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:76.779%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Allocation Method</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Description</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">OPM</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The OPM model treats preferred stock as call options on the enterprise’s equity value, with exercise prices based on the liquidation preferences of the preferred stock.</span><span style="color:#000000;font-family:'Arial',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">PWERM</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Under a PWERM, share value is based upon the probability-weighted present value of expected future investment returns, considering each of the possible future outcomes available to the enterprise, as well as the rights of each share class. </span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Hybrid</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The hybrid method is a combination of the PWERM and OPM. Under the hybrid method, multiple liquidity scenarios are weighted based on the probability of the scenario's occurrence, similar to the PWERM, while also utilizing the OPM to estimate the allocation of value in one or more of the scenarios. </span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div>The Group measures fair value using the following fair value hierarchy that reflects the significance of the inputs used in making the measurements:<div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:21.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:76.779%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Fair Value<br/>Hierarchy Level</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Description</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Level 1</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Inputs that are quoted market prices (unadjusted) in active markets for identical instruments.</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Level 2</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Inputs other than quoted prices included within Level 1 that are observable either directly (i.e. as prices) or indirectly (i.e. derived from prices). </span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Level 3</span></td><td colspan="3" style="border-bottom:0.25pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Inputs that are unobservable. This category includes all instruments for which the valuation technique includes inputs not based on observable data and the unobservable inputs have a significant effect on the instruments' valuation. </span></div></td></tr></table></div> <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes the changes in the Group’s subsidiary preferred shares and convertible notes liabilities measured at fair value, which were categorized as Level 3 in the fair value hierarchy:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"><div style="margin-bottom:10pt"><span><br/></span></div></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Subsidiary Preferred Shares<br/>$</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Subsidiary Convertible<br/>Notes<br/>$</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">118,972 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25,000 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Value at issuance</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">37,610 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,215 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Conversion to subsidiary preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">25,797 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(25,797)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest - contractual</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,362)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">175 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at December 31, 2021 and January 1, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">174,017 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,461 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Value at issuance</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">393 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest - contractual</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation - Sonde</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(15,853)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,403)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(130,825)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">502 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at December 31, 2022 and January 1, 2023</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in fair value</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,617)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation - Vedanta</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24,554)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 118972000 25000000 37610000 2215000 25797000 -25797000 0 867000 -8362000 175000 174017000 2461000 0 393000 0 48000 15853000 3403000 -130825000 502000 27339000 0 -2617000 0 24554000 0 169000 0 -7298000 0 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes the changes in all the Group’s investments held at fair value, which were categorized as Level 3 in the fair value hierarchy:</span></div><div style="margin-bottom:5.25pt;text-align:justify"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">206,892 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash purchase of Vor preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">500 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reclassification of Vor from level 3 to level 1</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(33,365)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on change in fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">65,505 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at December 31, 2021</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">239,533 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of Sonde</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,168 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gelesis Earn-out Shares received in the SPAC exchange</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,214 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Exchange of Gelesis preferred shares to Gelesis common shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,303)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reclassification of Akili to level 1 investment</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(128,764)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on change in fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(31,253)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31, 2022</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">12,593 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of Vedanta - new investment in Vedanta preferred shares</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">20,456 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Gelesis 2023 Warrants</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,121 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gain/(loss) on changes in fair value</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(9,299)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance as of December 31, 2023</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">24,872</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div> 206892000 500000 33365000 65505000 239533000 11168000 14214000 -92303000 128764000 -31253000 12593000 20456000 1121000 -9299000 24872000 10408000 14153000 The significant unobservable inputs used at December 31, 2023 in the fair value measurement of these investments and the sensitivity of the fair value measurements for these investments to changes to these significant unobservable inputs are summarized in the table below. <div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:47.536%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.022%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31, 2023</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment (Sonde) Measured through </span></div><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Market Backsolve &amp; OPM</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Unobservable Inputs</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Input Value </span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Sensitivity Range</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Investment Fair Value Increase/(Decrease)</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity Value</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">53,242</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-5 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(464)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+5%</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">463 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Time to Liquidity</span></td><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:right;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2.00</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-6 Months</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">39 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+ 6 Months</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(42)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Volatility</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">60 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-10 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">19</span></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+10%</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 35 Light',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(35)</span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:47.536%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.021%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.022%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31, 2023</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment (Vedanta) Measured through Market Backsolve that Leverages a Monte Carlo Simulation</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Unobservable Inputs</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Input Value </span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Sensitivity Range</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Investment Fair Value Increase/(Decrease)</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity Value</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">127,883</span></td><td colspan="2" style="border-top:0.25pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-5 </span></td><td style="border-top:0.25pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,416)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+5%</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,069 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Time to Liquidity</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1.23</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">- 6 Months</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,907)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+ 6 Months</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,261 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #001544;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Volatility</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">120 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">-10 </span></td><td style="border-top:0.25pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">%</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(954)</span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.25pt solid #001544;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">+10%</span></td><td colspan="2" style="border-bottom:0.25pt solid #001544;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">474 </span></td><td style="border-bottom:0.25pt solid #001544;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 53242000 0.05 -464000 0.05 463000 2.00 P6M 39000 P6M -42000 0.60 -0.10 19000 0.10 -35000 127883000 0.05 -1416000 0.05 1069000 1.23 P6M -3907000 P6M 1261000 1.20 0.10 -954000 0.10 474000 16501000 10729000 5000000 -27630000 -27230000 -400000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The fair value of financial instruments by category as of December 31, 2023 and 2022:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.960%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:9.657%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="21" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Carrying Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="12" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Fair Value</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Financial Assets<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Financial Liabilities<br/>$</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Level 1<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Level 2<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Level 3<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Total<br/>$</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Financial assets</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:5.52pt;font-weight:700;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">:</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Money Markets</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1,2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">156,705</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">156,705</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">156,705</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in notes from associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,600</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,600</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,600</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">317,841</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">292,970</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">24,872</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">317,841</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total financial assets</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">479,146</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">449,675</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">29,472</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">479,146</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Financial liabilities:</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based liability awards</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,782</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,782</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,782</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total financial liabilities</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,951</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,951</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,951</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    Issued by a diverse group of corporations, largely consisting of financial institutions, virtually all of which are investment grade.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Included within cash and cash equivalents.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">3. Excluded from the table above are short-term investments of $136,062 that are classified at amortized cost as of December 31, 2023. The cost of these short-term investments approximates current fair value. </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:29.203%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="21" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td></tr><tr><td colspan="3" style="padding:0 1pt"><div style="margin-bottom:10pt"><span><br/></span></div></td><td colspan="6" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Carrying Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="12" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Fair Value</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Financial Assets<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Financial Liabilities<br/>$</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Level 1<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Level 2<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Level 3<br/>$</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total<br/>$</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial assets:</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Money Markets</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1,2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">95,249 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">95,249 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">95,249 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term investments</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Note from associate</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">16,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">16,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">16,501 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">251,892 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">239,299 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">12,593 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">251,892 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other receivables</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">3</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total financial assets</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">575,738 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">534,777 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,094 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">575,738 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Financial liabilities:</span></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #000;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary warrant liability</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary preferred shares</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary notes payable</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,097 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">248 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based liability awards</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,932 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,396 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,537 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,932 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total financial liabilities</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">35,664 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,396 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,097 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,171 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">35,664 </span></td><td style="border-bottom:0.25pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    Issued by a diverse group of corporations, largely consisting of financial institutions, virtually all of which are investment grade.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Included within cash and cash equivalents.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">3 Outstanding receivables are owed primarily by government agencies and large corporations, virtually all of which are investment grade.</span></div> 156705000 156705000 0 0 156705000 4600000 0 0 4600000 4600000 317841000 292970000 0 24872000 317841000 479146000 449675000 0 29472000 479146000 169000 0 0 169000 169000 4782000 0 0 4782000 4782000 4951000 0 0 4951000 4951000 136062000 95249000 95249000 0 0 95249000 200229000 200229000 0 0 200229000 16501000 0 0 16501000 16501000 251892000 239299000 0 12593000 251892000 11867000 0 11867000 0 11867000 575738000 534777000 11867000 29094000 575738000 47000 0 0 47000 47000 27339000 0 0 27339000 27339000 2345000 0 2097000 248000 2345000 5932000 4396000 0 1537000 5932000 35664000 4396000 2097000 29171000 35664000 Subsidiary Notes Payable <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The subsidiary notes payable are comprised of loans and convertible notes. As of December 31, 2023 and December 31, 2022, the loan in Follica and the convertible notes for Knode and Appeering did not contain embedded derivatives and therefore these instruments continue to be held at amortized cost. The notes payable consist of the following:</span></div><div style="margin-bottom:5.25pt;margin-top:4pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31,</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loans</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,439</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,097 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Convertible notes</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">260</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">248 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total subsidiary notes payable</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,699</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loans</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In October 2010, Follica entered into a loan and security agreement with Lighthouse Capital Partners VI, L.P. The loan is secured by Follica’s assets, including Follica’s intellectual property and bears interest at a rate of 5.0 percent in the interest only period and 12.0 percent in the repayment period.</span></div><div style="margin-top:5pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Convertible Notes</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Convertible Notes outstanding were as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"><div style="margin-bottom:10pt"><span><br/></span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Knode</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Appeering</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Sonde</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="24" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">January 1, 2022</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">94 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">141 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,461 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,696 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gross principal - issuance of notes - financing activity</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">393 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">393 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest on convertible notes - finance costs</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">60 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in fair value - finance costs</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">502 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">502 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,403)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,403)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">December 31, 2022 and January 1, 2023</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">99 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">248 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest on convertible notes - finance costs</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">December 31, 2023</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">104</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">156</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">260</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On April 6, 2021, and on November 24, 2021, Sonde issued unsecured convertible promissory notes to its existing shareholders for a combined total of $4,329, of which $2,215 were issued to third-party shareholders (and $2,113 were issued to the Group and eliminated in consolidation). In addition, in March 2022, Sonde issued an additional amount of $921, of which $393 were issued to third parties (and $528 issued to the Group and eliminated in consolidation). The notes bore interest at an annual rate of 6.0 percent and were to mature on the second anniversary of the issuance. The notes were to mandatorily convert in a Qualified Financing, as defined in the note purchase agreement, at a discount of 20.0 percent from the price per share in the Qualified Financing. In addition, the notes allowed for optional conversion concurrently with a discount of 20.0 percent from the price per share in the Non Qualified Equity Financing. Upon the completion of the Preferred B round of financing in Sonde on May 25, 2022, the Group lost control in Sonde and all convertible notes were derecognized as part of the deconsolidation - See Note 5. Investments Held at Fair Value.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For Sonde convertible notes, since these notes contained embedded derivatives, the notes were assessed under IFRS 9 and the entire financial instruments were elected to be accounted for as FVTPL. The Sonde notes were deconsolidated in May 2022 as described above.</span></div> The notes payable consist of the following:<div style="margin-bottom:5.25pt;margin-top:4pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31,</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loans</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,439</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,097 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Convertible notes</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">260</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">248 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total subsidiary notes payable</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,699</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div> 3439000 2097000 260000 248000 3699000 2345000 0.05 0.12 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Convertible Notes outstanding were as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.839%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"><div style="margin-bottom:10pt"><span><br/></span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Knode</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Appeering</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Sonde</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="24" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">January 1, 2022</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">94 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">141 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,461 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,696 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Gross principal - issuance of notes - financing activity</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">393 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">393 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest on convertible notes - finance costs</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">60 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Change in fair value - finance costs</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">502 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">502 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,403)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,403)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">December 31, 2022 and January 1, 2023</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">99 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">248 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest on convertible notes - finance costs</span></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">December 31, 2023</span></div></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">104</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">156</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">260</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 94000 141000 2461000 2696000 0 0 393000 393000 5000 8000 48000 60000 0 0 502000 502000 0 0 3403000 3403000 99000 149000 0 248000 5000 8000 0 13000 104000 156000 0 260000 4329000 2215000 2113000 921000 393000 528000 0.06 0.20 0.20 Non-Controlling Interest<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023, non-controlling interests include Entrega and Follica. Ownership interests of the non-controlling interests in these entities as of December 31, 2023 were 11.7 percent, and 19.9 percent, respectively. As of December 31, 2022, non-controlling interests include Entrega, Follica, and Vedanta. Ownership interests of the non-controlling interests in these entities were 11.7 percent , 19.9 percent, and 12.2 percent, respectively. As of December 31, 2021, non-controlling interests include Entrega, Follica, Sonde, and Vedanta. Ownership interests of the non-controlling interests in these entities were 11.7 percent, 19.9 percent, 6.2 percent and 3.7 percent, respectively. During the year ended December 31, 2023, Vedanta Biosciences, Inc was deconsolidated. During the year ended December 31, 2022, Sonde Health, Inc was deconsolidated. See Note 5. Investments Held at Fair Value. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Non-controlling interests include the amounts recorded for subsidiary stock options.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On June 11, 2021, the Group acquired the remaining 17.1 percent of the minority non-controlling interests of Alivio (after exercise of all in the money stock options) increasing its ownership to 100.0 percent of Alivio. The consideration for such non-controlling interests amounted to $1,224, to be paid in three equal installments, with the first installment of $408 paid at the effective date of the transaction and two additional installments to be paid upon the occurrence of certain contingent events. The Group recorded a contingent consideration liability of $560 at fair value for the two additional installments, resulting in a total acquisition cost of $968. The excess of the consideration paid over the book value of the non-controlling interest of approximately $9,636 was recorded directly as a charge to shareholders’ equity. The second installment of $408 was paid in July 2021, upon the occurrence of the contingent event specified in the agreement. The contingent consideration liability was adjusted to fair value at the end of each reporting period with changes in fair value recorded in earnings. Changes in fair value of the aforementioned contingent consideration liability were not material. As of December 31, 2022, the remaining contingent liability was reduced to zero as the second contingent event did not occur.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On December 1, 2021, option holders in Entrega exercised options into shares of common stock, increasing the NCI interest held from 0.2 percent to 11.7 percent. During 2021, option holders in Vedanta exercised options and increased the NCI interest to 3.7 percent. The exercise of the options resulted in an increase in the NCI share in Entrega and Vedanta shareholder's deficit of $5,887. The amount together with the consideration paid by NCI ($101) amounted to $5,988 and was recorded as a gain directly in shareholders' equity.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On February 15, 2022, option holders in Vedanta exercised options into shares of common stock, increasing the NCI interest held from 3.7 percent to 12.2 percent. The exercise of the options resulted in an increase in the NCI share in Vedanta shareholder's deficit of $15,171. The amount together with the consideration paid by NCI ($7) amounted to $15,171 and was recorded as a gain directly in shareholders' equity.</span></div> 0.117 0.199 0.117 0.199 0.122 0.117 0.199 0.062 0.037 0.171 1 1224000 3 408000 560000 968000 9636000 408000 0.002 0.117 0.037 5887000 101000 5988000 0.037 0.122 15171000 7000 15171000 Trade and Other Payables <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Information regarding Trade and other payables was as follows: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31,</span></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade payables</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">14,637</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26,504 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">28,187</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">24,518 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income tax payable</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Liability for share-based awards</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,281</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,805 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,957 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total trade and other payables</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">44,107</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54,840 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div> <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Information regarding Trade and other payables was as follows: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31,</span></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade payables</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">14,637</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">26,504 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued expenses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">28,187</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">24,518 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income tax payable</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">57 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Liability for share-based awards</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,281</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,805 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,957 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total trade and other payables</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">44,107</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54,840 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div> 14637000 26504000 28187000 24518000 0 57000 1281000 1805000 3000 1957000 44107000 54840000 Long-term loan<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In September 2020, Vedanta entered into a $15,000 loan and security agreement with Oxford Finance LLC. The loan is secured by Vedanta's assets, including equipment, inventory and intellectual property. The loan bears a floating interest rate of 7.7 percent plus the greater of (i) 30 day U.S. Dollar LIBOR reported in the Wall Street Journal or (ii) 0.17 percent. The loan matures September 2025 and requires interest-only payments prior to 2023. The loan also carries a final fee upon full repayment of 7.0 percent of the original principal, or $1,050. As part of the loan agreement, Vedanta also issued Oxford Finance LLC 12,886 Series C-2 preferred share warrants with an exercise price of $23.28 per share, expiring September 2030. The outstanding loan balance totaled approximately $15,400 as of December 31, 2022. On March 1, 2023, the Group derecognized the loan in connection with Vedanta's deconsolidation. Refer to Note 5. Investments Held at Fair Value. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes long-term loan activity for the years ended December 31, 2023 and 2022:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Long-term loan</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1,</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">15,400</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,118 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">363</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,755 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest paid</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(300)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,436)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other</span></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(17)</span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(38)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(15,446)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31,</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,400 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The long-term loan is presented as follows in the Statement of Financial Position as of December 31, 2023 and 2022: </span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:middle"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Long-term loan</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Current portion of long-term loan</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,156 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Long-term loan</span></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,244 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total Long-term loan</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,400 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 15000000 0.077 0.0017 0.07 1050000 12886 23.28 15400000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table summarizes long-term loan activity for the years ended December 31, 2023 and 2022:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Long-term loan</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1,</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">15,400</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,118 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Accrued interest</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">363</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,755 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest paid</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(300)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,436)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other</span></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(17)</span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(38)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(15,446)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31,</span></div></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,400 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 15400000 15118000 363000 1755000 300000 1436000 17000 38000 15446000 0 0 15400000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The long-term loan is presented as follows in the Statement of Financial Position as of December 31, 2023 and 2022: </span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:middle"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Long-term loan</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Current portion of long-term loan</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,156 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Long-term loan</span></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,244 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total Long-term loan</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,400 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 0 5156000 0 10244000 0 15400000 Leases and subleases<div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The activity related to the Group’s right of use asset and lease liability for the years ended December 31, 2023 and 2022 is as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Right of use asset, net</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1,</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">14,281</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">17,166 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">163 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,979)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,047)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidated</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,477)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31,</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">9,825</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,281 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total lease liability</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1,</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">29,128</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">32,990 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">163 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash paid for rent - principal - financing cash flow</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(3,338)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(4,025)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash paid for rent - interest </span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,544)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,982)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest expense</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,544</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,982 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidated</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(4,146)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31,</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21,644</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,128 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation of the right-of-use assets, which virtually all consist of leased real estate, is included in the general and administrative expenses and research and development expenses line items in the Statement of Comprehensive Income/(Loss). The Group recorded depreciation expense of $1,979, $3,047 and $2,938 for the years ended December 31, 2023, 2022 and 2021, respectively.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table details the short-term and long-term portion of the lease liability as of December 31, 2023 and 2022:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:middle"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total lease liability</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term portion of lease liability</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,394</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,972 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Long-term portion of lease liability</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">18,250</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">24,155 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total lease liability</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21,644</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,128 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table details the future maturities of the lease liability, showing the undiscounted lease payments to be paid after the reporting date:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="6" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Less than one year</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,689</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">One to two years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,644</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Two to three years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,419</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Three to four years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,551</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Four to five years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,687</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">More than five years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,796</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total undiscounted lease maturities</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">25,785</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,141</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total lease liability</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21,644</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the year ended December 31, 2019, the Group entered into a lease agreement for certain premises consisting of 50,858 rentable square feet of space located at 6 Tide Street, Boston, Massachusetts. The lease commenced on April 26, 2019 for an initial term consisting of ten years and three months, and there is an option to extend the lease for two consecutive periods of five years each. The Group assessed at the lease commencement date whether it was reasonably certain to exercise the extension options, and deemed such options were not reasonably certain to be exercised. The Group will reassess whether it is reasonably certain to exercise the options only if there is a significant event or significant change in circumstances within its control. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On June 26, 2019, the Group executed a sublease agreement with Gelesis. The lease is for 9,446 rentable square feet located on the sixth floor of the Group’s former office at 501 Boylston Street, Boston, Massachusetts. The sublease was set to expire on August 31, 2025, and was determined to be a finance lease. Gelesis ceased operations and filed for bankruptcy on October 30, 2023. As a result, the Group wrote off its receivable in the lease of $1,266 in 2023. </span></div>On January 23, 2023, the Group executed a sublease agreement with Allonnia, LLC (“Allonnia”). The sublease is for approximately 11,000 rentable square feet located on the third floor of the 6 Tide Street building where the Group’s offices are currently located. Allonnia obtained possession of the premises on February 17, 2023 with a rent commencement date of May 17, 2023. The lease term is two years from the rent commencement date, and Allonnia has the option to extend the sublease for an additional year at the same terms. The annual lease fee is $1,111 per year. The sublease was determined to be an operating lease, and as such, the total lease payments under the sublease agreement are recognized over the lease term on a straight-line basis. In February 2024, Allonnia exercised the option and extended the lease term through May 31, 2026<div style="margin-bottom:5pt;margin-top:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Rental income recognized by the Group during the year ended December 31, 2023 was $781 which was included in the other income/(expense) line item in the Consolidated Statement of Comprehensive Income/(Loss). In the year ended December 31, 2022, the Group did not recognize any rental income.</span></div> <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The activity related to the Group’s right of use asset and lease liability for the years ended December 31, 2023 and 2022 is as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Right of use asset, net</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1,</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">14,281</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">17,166 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">163 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Depreciation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,979)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,047)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidated</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,477)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31,</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">9,825</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,281 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 14281000 17166000 17166000 0 163000 1979000 3047000 2477000 0 9825000 14281000 <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total lease liability</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Balance at January 1,</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">29,128</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">32,990 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Additions</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">163 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash paid for rent - principal - financing cash flow</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(3,338)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(4,025)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash paid for rent - interest </span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,544)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1,982)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest expense</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,544</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,982 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidated</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(4,146)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Balance at December 31,</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21,644</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,128 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 29128000 32990000 0 163000 3338000 4025000 1544000 1982000 1544000 1982000 4146000 0 21644000 29128000 1979000 3047000 2938000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table details the short-term and long-term portion of the lease liability as of December 31, 2023 and 2022:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:middle"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total lease liability</span></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term portion of lease liability</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,394</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,972 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Long-term portion of lease liability</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">18,250</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">24,155 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total lease liability</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21,644</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">29,128 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 3394000 4972000 18250000 24155000 21644000 29128000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The following table details the future maturities of the lease liability, showing the undiscounted lease payments to be paid after the reporting date:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:87.384%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="6" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Less than one year</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,689</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">One to two years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,644</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Two to three years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,419</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Three to four years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,551</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Four to five years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,687</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">More than five years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,796</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total undiscounted lease maturities</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">25,785</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,141</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total lease liability</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21,644</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 4689000 4644000 4419000 4551000 4687000 2796000 25785000 4141000 21644000 50858 2 P5Y 9446 1266000 11000 P2Y 1111000 781000 0 Capital and Financial Risk Management <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Capital Risk Management</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group's capital and financial risk management policy is to maintain a strong capital base to support its strategic priorities, maintain investor, creditor and market confidence as well as sustain the future development of the business. The Group’s objectives when managing capital are to safeguard its ability to continue as a going concern, to provide returns for shareholders and benefits for other stakeholders, and to maintain an optimal capital structure to reduce the cost of capital. To maintain or adjust the capital structure, the Group may issue new shares or incur new debt. The Group has no material externally imposed capital requirements. The Group’s share capital is set out in Note 15. Equity.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Management continuously monitors the level of capital deployed and available for deployment in the Wholly-Owned Programs segment and at Founded Entities. The Directors seek to maintain a balance between the higher returns that might be possible with higher levels of deployed capital and the advantages and security afforded by a sound capital position.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group’s Directors have overall responsibility for the establishment and oversight of the Group's capital and risk management framework. The Group is exposed to certain risks through its normal course of operations. The Group’s main objective in using financial instruments is to promote the development and commercialization of intellectual property through the raising and investing of funds for this purpose. The nature, amount and timing of investments are determined by planned future investment activity. Due to the nature of activities and with the aim to maintain the investors’ funds as secure and protected, the Group’s policy is to hold any excess funds in highly liquid and readily available financial instruments and maintain minimal exposure to other financial risks.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has exposure to the following risks arising from financial instruments:</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Credit Risk</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Credit risk is the risk of financial loss to the Group if a customer or counterparty to a financial instrument fails to meet its contractual obligations. Financial instruments that potentially subject the Group to concentrations of credit risk consist principally of cash and cash equivalents, short-term investments, and trade and other receivables. The Group held the following balances (not including the income tax receivable resulting from overpayment of income taxes as of December 31, 2022. See Note 27. Taxation):</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash and cash equivalents</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">191,081</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149,866 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term investments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">136,062</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other receivables</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,376</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">329,518</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">361,961 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group invests its excess cash in U.S. Treasury Bills (presented as short-term investments), and money market accounts, which the Group believes are of high credit quality. Further, the Group's cash and cash equivalents and short-term investments are held at diverse, investment-grade financial institutions.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group assesses the credit quality of customers on an ongoing basis. The credit quality of financial assets is assessed by historical and recent payment history, counterparty financial position, and reference to credit ratings (if available) or to historical information about counterparty default rates. The Group does not have expected credit losses due to the high credit quality or healthy financial conditions of these counterparties. As of December 31, 2023 and 2022, none of the trade and other receivables were impaired.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Liquidity Risk</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Liquidity risk is the risk that the Group will encounter difficulty in meeting the obligations associated with its financial liabilities that are settled by delivering cash or another financial asset. The Group actively manages its liquidity risk by closely monitoring the maturity of its financial assets and liabilities and projected cash flows from operations, under both normal and stressed conditions, without incurring unacceptable losses or risking damage to the Group’s reputation. Due to the nature of these financial liabilities, the funds are available on demand to provide optimal financial flexibility.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The table below summarizes the maturity profile of the Group’s financial liabilities, including subsidiary preferred shares that have customary liquidation preferences, as of December 31, 2023 and 2022, based on contractual undiscounted payments:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:41.324%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td><td colspan="15" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td></tr><tr style="height:26pt"><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Carrying Amount<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Within Three Months<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Three to Twelve Months<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">One to Five Years<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Total<br/>$ (*)</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary notes payable</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,699</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,699</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,699</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other payables</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">44,107</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">44,107</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">44,107</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary preferred shares (Note 16)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47,975</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47,975</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47,975</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:41.324%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td><td colspan="15" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td></tr><tr style="height:26pt"><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Carrying Amount<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Within Three Months<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Three to Twelve Months<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">One to Five Years<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total<br/>$ (*)</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Long-term loan</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,400 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,838 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,281 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,413 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">18,531 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary notes payable</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other payables</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54,840 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54,840 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54,840 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Warrants</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary preferred shares (Note 16)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">99,971 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86,409 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,281 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,413 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">103,103 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    Redeemable only upon a liquidation or deemed liquidation event, as defined in the applicable shareholder documents.</span></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Warrants issued by subsidiaries to third parties to purchase preferred shares.</span></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">*    Does not include payments in respect of lease obligations. For the contractual future payments related to lease obligation</span><span style="background-color:#ffffff;color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">s, see Note 23. Leases and subleases.</span></div><div style="margin-bottom:2pt;padding-left:11.34pt;text-indent:-11.34pt"><span><br/></span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Interest Rate Sensitivity </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023, the Group had cash and cash equivalents of $191,081, and short-term investments of $136,062. The Group's exposure to interest rate sensitivity is impacted by changes in the underlying U.K. and U.S. bank interest rates. The Group has not entered into investments for trading or speculative purposes. Due to the conservative nature of the Group's investment portfolio, which is predicated on capital preservation and investments in short duration, high-quality U.S. Treasury Bills and related money market accounts, a change in interest rates would not have a material effect on the fair market value of the Group's portfolio, and therefore, the Group does not expect operating results or cash flows to be significantly affected by changes in market interest rates.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Controlled Founded Entity Investments</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group maintains investments in certain Controlled Founded Entities. The Group’s investments in Controlled Founded Entities are eliminated as intercompany transactions upon financial consolidation. The Group is, however, exposed to a preferred share liability owing to the terms of existing preferred shares and the ownership of Controlled Founded Entities preferred shares by third parties. As discussed in Note 16. Subsidiary Preferred Shares, certain of the Group’s subsidiaries have issued preferred shares that include the right to receive a payment in the event of any voluntary or involuntary liquidation, dissolution or winding up of a subsidiary, including in the event of "deemed liquidation" as defined in the incorporation documents of the entities, which shall be paid out of the assets of the subsidiary available for distribution to shareholders, and before any payment shall be made to holders of ordinary shares. The liability of preferred shares is maintained at fair value through the profit and loss. The Group’s cash position supports the business activities of the Controlled Founded Entities. Accordingly, the Group views exposure to the third party preferred share liability as low.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidated Founded Entity Investments</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group maintains certain debt or equity holdings in Founded Entities that are deconsolidated. These holdings are deemed either as investments and accounted for as investments held at fair value, or as associates and accounted for under the equity method. The Group's exposure to investments held at fair value is $317,841 as of December 31, 2023, and the Group may or may not be able to realize the value in the future. Accordingly, the Group views the risk as high. The Group’s exposure to investments in associates is limited to the carrying amount of the investment in an associate. The Group is not exposed to further contractual obligations or contingent liabilities beyond the value of the initial investments. Accordingly, the Group does not view this as a high risk. As of December 31, 2023, Sonde is the only associate, and the carrying amount of the investment as associate is $3,185.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Equity Price Risk</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023, the Group held 886,885 common shares of Karuna, 2,671,800 common shares of Vor and 12,527,477 common shares of Akili. The fair value of these investments in Karuna, Vor and Akili was $292,831, of which approximately 96% is related to the Karuna common shares. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The investments in Karuna, Vor and Akili are exposed to fluctuations in the market price of these common shares. The effect of a 10.0 percent adverse change in the market price of Karuna, Vor and Akili common shares would cause a loss of approximately $29,283 to be recognized as a component of other income (expense) in the Consolidated Statement of Comprehensive Income/(Loss). However, the Group views exposure to equity price risk as low due to the definitive merger agreement Karuna entered into with Bristol Myers Squibb "BMS") in December 2023 under which Karuna common shares were acquired by Bristol Myers Squibb for $330 per share in March 2024. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Foreign Exchange Risk</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group maintains consolidated financial statements in the Group's functional currency, which is the U.S. dollar. Monetary assets and liabilities denominated in currencies other than the functional currency are translated into the functional currency at exchange rates prevailing at the balance sheet dates. Non-monetary assets and liabilities denominated in foreign currencies are translated into the functional currency at the exchange rates prevailing at the date of the transaction. Exchange gains or losses arising from foreign currency transactions are included in the determination of net income (loss) for the respective periods. Such foreign currency gains or losses were not material for all reported periods. </span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group does not currently engage in currency hedging activities since its foreign currency risk is limited, but the Group may begin to do so in the future if and when its foreign currency risk exposure changes.</span></div> The Group held the following balances (not including the income tax receivable resulting from overpayment of income taxes as of December 31, 2022. See Note 27. Taxation):<div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Cash and cash equivalents</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">191,081</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">149,866 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term investments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">136,062</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">200,229 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other receivables</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,376</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,867 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">329,518</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">361,961 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div> 191081000 149866000 136062000 200229000 2376000 11867000 329518000 361961000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The table below summarizes the maturity profile of the Group’s financial liabilities, including subsidiary preferred shares that have customary liquidation preferences, as of December 31, 2023 and 2022, based on contractual undiscounted payments:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:41.324%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td><td colspan="15" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td></tr><tr style="height:26pt"><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Carrying Amount<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Within Three Months<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Three to Twelve Months<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">One to Five Years<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Total<br/>$ (*)</span></div></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary notes payable</span></div></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,699</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,699</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,699</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other payables</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">44,107</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">44,107</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">44,107</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary preferred shares (Note 16)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">169</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47,975</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47,975</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47,975</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:41.324%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td><td colspan="15" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td></tr><tr style="height:26pt"><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Carrying Amount<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Within Three Months<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Three to Twelve Months<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">One to Five Years<br/>$</span></div></td><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Total<br/>$ (*)</span></div></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Long-term loan</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">15,400 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,838 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,281 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,413 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">18,531 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary notes payable</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,345 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other payables</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54,840 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54,840 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54,840 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Warrants</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">47 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Subsidiary preferred shares (Note 16)</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">1</span></div></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">27,339 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">99,971 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">86,409 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,281 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,413 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">103,103 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    Redeemable only upon a liquidation or deemed liquidation event, as defined in the applicable shareholder documents.</span></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Warrants issued by subsidiaries to third parties to purchase preferred shares.</span></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.17pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">*    Does not include payments in respect of lease obligations. For the contractual future payments related to lease obligation</span><span style="background-color:#ffffff;color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">s, see Note 23. Leases and subleases.</span></div> 3699000 3699000 0 0 3699000 44107000 44107000 0 0 44107000 169000 169000 0 0 169000 47975000 47975000 0 0 47975000 15400000 1838000 5281000 11413000 18531000 2345000 2345000 0 0 2345000 54840000 54840000 0 0 54840000 47000 47000 0 0 47000 27339000 27339000 0 0 27339000 99971000 86409000 5281000 11413000 103103000 191081000 136062000 317841000 3185000 886885 2671800 12527477 292831000 0.96 0.10 -29283000 330 Commitments and Contingencies <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group is a party to certain licensing agreements where the Group is licensing IP from third parties. In consideration for such licenses, the Group has made upfront payments and may be required to make additional contingent payments based on developmental and sales milestones and/or royalty on future sales. As of December 31, 2023, certain milestone events have not yet occurred, and therefore, the Group does not have a present obligation to make the related payments in respect of the licenses. Such milestones are dependent on events that are outside of the control of the Group, and many of these milestone events are remote of occurring. As of December 31, 2023 and December 31, 2022, payments in respect of developmental milestones that are dependent on events that are outside the control of the Group but are reasonably possible to occur amounted to approximately $7,371 and $8,666, respectively. These milestone amounts represent an aggregate of multiple milestone payments depending on different milestone events in multiple agreements. The probability that all such milestone events will occur in the aggregate is remote. Payments made to license IP represent the acquisition cost of intangible assets. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group was a party to certain sponsored research arrangements and is a party to arrangements with contract manufacturing and contract research organizations, whereby the counterparty provides the Group with research and/or manufacturing services. As of December 31, 2023 and 2022, the noncancellable commitments in respect of such contracts amounted to approximately $16,422 and $11,288, respectively.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In March 2024, a complaint was filed in Massachusetts District Court against the Group alleging breach of contract with respect to certain payments alleged to be owed to a previous employee of a Group subsidiary based on purported terms of a contract between such individual and the Group. The Group intends to defend itself vigorously though the ultimate outcome of this matter and the timing for resolution remains uncertain. No determination has been made that a loss, if any, arising from this matter is probable or that the amount of any such loss, or range of loss, is reasonably estimable.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group is involved from time-to-time in various legal proceedings arising in the normal course of business. Although the outcomes of these legal proceedings are inherently difficult to predict, the Group does not expect the resolution of such legal proceedings to have a material adverse effect on its financial position or results of operations. The Group did not book any provisions and did not identify any contingent liabilities requiring disclosure for any legal proceedings other than already included above for the years ended December 31, 2023 and 2022.</span></div> 7371000 8666000 16422000 11288000 Related Parties Transactions <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Related Party Subleases and Royalties </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During 2019, the Group executed a sublease agreement with a related party, Gelesis. As of December 31, 2022, the sublease receivable amounted to $1,285. During 2023, the sublease receivable was written down to $0 as Gelesis ceased operations and filed for bankruptcy.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group recorded $23, $89 and $113 of interest income with respect to the sublease during the years ended December 31, 2023, 2022, and 2021, respectively, which is presented within finance income in the Consolidated Statement of Comprehensive Income/(Loss).</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group received royalties from Gelesis on its product sales. The Group recorded zero, $509, and $231 of royalty revenue during the years ended December 31, 2023, 2022, 2021, respectively, which is presented in contract revenue in the Consolidated Statement of Comprehensive Income/(Loss).</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Key Management Personnel Compensation</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Key management includes executive directors and members of the executive management team of the Group (not including non-executive directors). The key management personnel compensation of the Group was as follows for the years ended December 31: </span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term employee benefits</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">9,714</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,162 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,612 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Post-employment benefits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">41</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">55 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Termination Benefits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">417</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">152 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payment expense</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">599</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,741 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,045 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">10,772</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,109 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,711 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term employee benefits include salaries, health care and other non-cash benefits. Post-employment benefits include 401K contributions from the Group. Termination benefits include severance pay. Share-based payments are generally subject to vesting terms over future periods. See Note 9. Share-based Payments. As of 12/31/2023, the payable due to the key management employees was $4,732.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In addition the Group paid remuneration to non-executive directors in the amounts of $475, $655 and $605 for the years ended December 31, 2023, 2022 and 2021, respectively. Also, the Group incurred $373, $365, and $161 of stock based compensation expense for such non-executive directors for the years ended December 31, 2023, 2022, and 2021, respectively.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">During the years ended December 31, 2023 and 2022, the Group incurred $46, and $51, respectively, of expenses paid to related parties.</span></div><div><span style="background-color:#ffffff;color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Convertible Notes Issued to Directors</span></div><div style="margin-bottom:5pt"><span style="background-color:#ffffff;color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Certain related parties of the Group have invested in convertible notes issued by the Group’s subsidiaries. As of </span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">December 31, 2023 and December 31, 2022,</span><span style="background-color:#ffffff;color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> the outstanding related party notes payable</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> totaled $104 and $99,</span><span style="background-color:#ffffff;color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> respectively, including principal and interest. </span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The notes issued to related parties bear interest rates, maturity dates, discounts and other contractual terms that are the same as those issued to outside investors during the same issuances.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Directors’ and Senior Managers’ Shareholdings and Share Incentive Awards</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Directors and senior managers hold beneficial interests in shares in the following businesses and sourcing companies as of December 31, 2023:</span></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:23.445%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:28.293%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.566%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.475%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.566%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:9.055%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Business name (share class)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of shares held as of December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of options held as of December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of RSUs held as of December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Ownership<br/>interest¹</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Directors:</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Dr Robert Langer</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega (Common)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">250,000</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">82,500</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4.09</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Dr Raju Kucherlapati</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Enlight (Class B Common)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">30,000</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3.00</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Dr John LaMattina</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Akili (Common)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">56,554</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.07</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences (Common)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">25,000</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">15,000</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.24</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Senior Managers:</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Dr Bharatt Chowrira</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Karuna (Common)</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,000</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.01</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    Ownership interests as of December 31, 2023 are calculated on a diluted basis, including issued and outstanding shares, warrants and options (and written commitments to issue options) but excluding unallocated shares authorized to be issued pursuant to equity incentive plans and any shares issuable upon conversion of outstanding convertible promissory notes.</span></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Dr John LaMattina holds convertible notes issued by Appeering in the aggregate principal amount of $50,000.</span></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span><br/></span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Directors and senior managers hold 23,547,554 ordinary shares and 11.5 percent voting rights of the Group as of December 31, 2023. This amount excludes options to purchase 2,262,500 ordinary shares. This amount also excludes 7,301,547 shares, which are issuable based on the terms of performance based RSU awards granted to certain senior managers covering the financial years 2023, 2022 and 2021, and 102,732 shares, which are issuable to directors immediately prior to the Group's 2024 Annual General Meeting of Stockholders, based on the terms of the RSU awards granted to non-executive directors in 2023. Such shares will be issued to such senior managers and non-executive directors in future periods provided that performance and/or service conditions are met, and certain of the shares will be withheld for payment of customary withholding taxes.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">See Note 7. Investment in Notes from Associates for details on the notes issued by Gelesis and Vedanta to the Group. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">As of December 31, 2023, the Group has a receivable from Sonde and Vedanta in the amount of $1,569.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">See Note 6. Investments in Associates for details on the execution and termination of Merger Agreement with Gelesis.</span></div> 1285000 0 23000 89000 113000 0 509000 231000 The key management personnel compensation of the Group was as follows for the years ended December 31: <div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Short-term employee benefits</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">9,714</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,162 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,612 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Post-employment benefits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">41</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">55 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">54 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Termination Benefits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">417</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">152 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payment expense</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">599</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,741 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">4,045 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">10,772</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,109 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,711 </span></td><td style="border-bottom:0.5pt solid #000;border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 9714000 4162000 4612000 41000 55000 54000 417000 152000 0 599000 2741000 4045000 10772000 7109000 8711000 4732000 475000 655000 605000 373000 365000 161000 46000 51000 104000 99000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Directors and senior managers hold beneficial interests in shares in the following businesses and sourcing companies as of December 31, 2023:</span></div><div style="margin-bottom:1pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:23.445%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:28.293%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.566%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:11.475%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.566%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:9.055%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Business name (share class)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of shares held as of December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of options held as of December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Number of RSUs held as of December 31, 2023</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Ownership<br/>interest¹</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Directors:</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Dr Robert Langer</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Entrega (Common)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">250,000</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">82,500</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4.09</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Dr Raju Kucherlapati</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Enlight (Class B Common)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">30,000</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3.00</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Dr John LaMattina</span><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:5.52pt;font-weight:400;line-height:120%;position:relative;top:-2.97pt;vertical-align:baseline">2</span></div></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Akili (Common)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">56,554</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.07</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Vedanta Biosciences (Common)</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">25,000</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">15,000</span></td><td colspan="3" style="padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.24</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Senior Managers:</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Dr Bharatt Chowrira</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Karuna (Common)</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,000</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="3" style="border-bottom:0.25pt solid #000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span></td><td colspan="2" style="border-bottom:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.01</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">%</span></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">1    Ownership interests as of December 31, 2023 are calculated on a diluted basis, including issued and outstanding shares, warrants and options (and written commitments to issue options) but excluding unallocated shares authorized to be issued pursuant to equity incentive plans and any shares issuable upon conversion of outstanding convertible promissory notes.</span></div><div style="margin-bottom:2pt;padding-left:14.17pt;text-indent:-14.18pt"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:6pt;font-weight:400;line-height:120%">2    Dr John LaMattina holds convertible notes issued by Appeering in the aggregate principal amount of $50,000.</span></div> 250000 82500 0 0.0409 0 30000 0 0.0300 56554 0 0 0.0007 25000 15000 0 0.0024 5000 0 0 0.0001 50000 23547554 0.115 2262500 7301547 7301547 7301547 102732 1569000 Taxation <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax on the profit or loss for the year comprises current and deferred income tax. Tax is recognized in the Consolidated Statement of Comprehensive Income/(Loss) except to the extent that it relates to items recognized directly in equity.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">For the years ended December 31, 2023, 2022 and 2021, the Group filed a consolidated U.S. federal income tax return which included all subsidiaries in which the Group owned greater than 80 percent of the vote and value. For the years ended December 31, 2023, 2022 and 2021, the Group filed certain consolidated state income tax returns which included all subsidiaries in which the Group owned greater than 50 percent of the vote and value. The remaining subsidiaries file separate U.S. tax returns.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amounts recognized in Consolidated Statement of Comprehensive Income/(Loss):</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/(loss) for the year</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(66,628)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(37,065)</span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(62,709)</span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income tax expense/(benefit)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">30,525</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(55,719)</span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,756 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Income/(loss) before taxes</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(36,103)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,783)</span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(58,953)</span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Recognized Income Tax Expense/(Benefit):</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Federal - current</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,246)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,065 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22,138 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">State - current</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(46)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,336 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">109 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total current income tax expense/(benefit)</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,292)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,401 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22,247 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Federal - deferred</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">29,294</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(48,240)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(15,416)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">State - deferred</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,523</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(21,880)</span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,075)</span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total deferred income tax expense/(benefit)</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">32,817</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(70,120)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(18,491)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total income tax expense/(benefit), recognized</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">30,525</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(55,719)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,756 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The income tax expense/(benefit) was $30,525, $(55,719) and $3,756 in 2023, 2022 and 2021 respectively. The increase in tax expense for the year ended December 31, 2023 was primarily attributable to a lower pre-tax loss in the tax consolidated U.S. group, the tax in respect of the sale of future royalties to Royalty Pharma and the tax impact of derecognizing previously recognized deferred tax assets that are no longer expected to be utilized.</span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Reconciliation of Effective Tax Rate</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group is primarily subject to taxation in the U.S. A reconciliation of the U.S. federal statutory tax rate to the effective tax rate is as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:28.596%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">%</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">%</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">%</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">US federal statutory rate</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(7,573)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21.00</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(19,486)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">21.00 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(12,380)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">21.00 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">State taxes, net of federal effect</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(3,974)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">11.01</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,043)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.67 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(4,484)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7.61 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax credits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(9,167)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">25.39</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,876)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7.41 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(5,056)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.58 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Stock-based compensation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">589</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1.63)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">788 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.85)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">555 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.94)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Finance income/(costs) – fair value accounting</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(556)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.54</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(28,783)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">31.02 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,017)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.42 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss with respect to associate for which no deferred tax asset is recognized</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">249</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(0.69)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,413 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1.52)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,542 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(19.58)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revaluation of deferred due to rate change</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.00</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,856)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9.54 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Nondeductible compensation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">872</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2.42)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">300 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.32)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">746 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1.27)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Recognition of deferred tax assets and tax benefits not previously recognized</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(433)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.20</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(184)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.20 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(414)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.70 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Unrecognized deferred tax asset</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">83,984</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(232.63)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">17,287 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(18.63)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,375 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24.38)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(17,506)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">48.49</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,572)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.85 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,321</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(3.65)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">293 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.32)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">889 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1.51)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Worthless stock deduction</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(17,281)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47.87</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">30,525</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(84.52)</span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(55,719)</span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">60.05 </span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,756</span></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6.37)</span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group is also subject to taxation in the UK, but to date, no taxable income has been generated in the UK. Changes in corporate tax rates can change both the current tax expense (benefit) as well as the deferred tax expense (benefit). </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred Tax Assets and Liabilities </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets have been recognized in the U.S. jurisdiction in respect of the following items:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating tax losses</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,849</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48,317 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax credits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,425</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,210</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,423 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Capitalized research &amp; development expenditures</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">39,422</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">36,084 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,036 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Lease liability</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,133</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,143 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sale of future royalties </span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">35,920</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other temporary differences</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,770</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,957 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">93,729</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">127,061 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(53,411)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(47,877)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Right of use assets</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,330)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,519)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Property and equipment, net</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,637)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,348)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(755)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax liabilities</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(58,133)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(53,744)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets (liabilities), net</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">35,596</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">73,317 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax liabilities, net, recognized</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(52,462)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(19,645)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets (liabilities), net, not recognized</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">88,058</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">92,962 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has recognized deferred tax assets due to future reversals of existing taxable temporary differences that will be sufficient to recover the deferred tax assets. Our unrecognized deferred tax assets of $88,058 are primarily related to tax credits, capitalized research &amp; development expenditures and deferred tax asset related to the sale of future royalties to Royalty Pharma. The Group does not believe it is probable that future taxable profit will be available to support the realizability of these unrecognized deferred tax assets. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Unrecognized Deferred Tax Assets</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets have not been recognized in respect of the following carryforward losses, credits and temporary differences, because it is not probable that future taxable profit will be available against which the Group can use the benefits therefrom.</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="6" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr style="height:9pt"><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Gross Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Tax Effected</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Gross Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Tax Effected</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deductible temporary difference</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">353,323</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">83,741</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">132,145 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">33,544 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax losses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">13,681</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,849</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">219,466 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48,317 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax credits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">468</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">468</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">367,472</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">88,058</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">362,712 </span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">92,962 </span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax Losses and Tax Credits Carryforwards </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax losses and tax credits for which no deferred tax asset was recognized are presented below:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td><td colspan="6" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td></tr><tr style="height:9pt"><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Gross Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Tax Effected</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Gross Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Tax Effected</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax losses expiring:</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Within 10 years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,741</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,284</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">23,930 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,387 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">More than 10 years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6,635</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,455</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">42,822 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,509 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Available Indefinitely</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,305</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,110</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">152,714 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">32,421 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">13,681</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,849</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">219,466 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48,317 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax credits expiring:</span></td><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.5pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Within 10 years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">43</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">43</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">43 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">43 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">More than 10 years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">425</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">425</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,058 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,058 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Available indefinitely</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">468</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">468</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group had U.S. federal net operating losses carry forwards (“NOLs”) of $13,681, $219,466 and $215,400 as of December 31, 2023, 2022 and 2021, respectively, which are available to offset future taxable income. These NOLs expire through 2037 with the exception of $2,305 which is not subject to expiration. The Group had U.S. federal research and development tax credits of approximately $1,396, $4,500 and $3,900 as of December 31, 2023, 2022 and 2021, respectively, which are available to offset future taxes that expire at various dates through 2043. The Group also had Federal Orphan Drug credits of approximately $930 and $6,100 as of December 31, 2023, and 2022, which are available to offset future taxes that expire at various dates through 2043. A portion of these federal NOLs and credits can only be used to offset the profits from the Group’s subsidiaries who file separate federal tax returns. These NOLs and credits are subject to review and possible adjustment by the Internal Revenue Service.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group had state net operating losses carry forwards (“NOLs”) of approximately $111,446, $71,700 and $27,900 for the years ended December 31, 2023, 2022 and 2021, respectively, which are available to offset future taxable income. These NOLs expire at various dates beginning in 2030. The Group had Massachusetts research and development tax credits of approximately $98, $600 and $1,300 for the years ended December 31, 2023, 2022 and 2021, respectively, which are available to offset future taxes and expire at various dates through 2038. These NOLs and credits are subject to review and possible adjustment by state taxing authority.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Utilization of the NOLs and research and development credit carryforwards may be subject to a substantial annual limitation under Section 382 of the Internal Revenue Code of 1986 due to ownership change limitations that have occurred previously or that could occur in the future. These ownership changes may limit the amount of NOL and research and development credit carryforwards that can be utilized annually to offset future taxable income and tax, respectively. The Group has performed a Section 382 analysis through December 31, 2023. The results of this analysis concluded that certain net operating losses were subject to limitation under Section 382 of the Internal Revenue Code. None of the Group’s net operating losses which are subject to a Section 382 limitation has been recognized in the financial statements. </span></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax Balances</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The tax related balances presented in the Statement of Financial Position are as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:11pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income tax receivable – current </span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">11,746</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,040 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other payables</span></div></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(57)</span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Uncertain Tax Positions</span></div><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has no uncertain tax positions as of December 31, 2023. U.S. corporations are routinely subject to audit by federal and state tax authorities in the normal course of business.</span></div> 0.80 0.80 0.80 0.50 0.50 0.50 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Amounts recognized in Consolidated Statement of Comprehensive Income/(Loss):</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income/(loss) for the year</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(66,628)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(37,065)</span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(62,709)</span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income tax expense/(benefit)</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">30,525</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(55,719)</span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,756 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Income/(loss) before taxes</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(36,103)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(92,783)</span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(58,953)</span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> -66628000 -37065000 -62709000 30525000 -55719000 3756000 -36103000 -92783000 -58953000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Recognized Income Tax Expense/(Benefit):</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Federal - current</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,246)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,065 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22,138 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">State - current</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(46)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,336 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">109 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total current income tax expense/(benefit)</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,292)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,401 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">22,247 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Federal - deferred</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">29,294</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(48,240)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(15,416)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">State - deferred</span></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,523</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(21,880)</span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,075)</span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:64.354%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total deferred income tax expense/(benefit)</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">32,817</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(70,120)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(18,491)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total income tax expense/(benefit), recognized</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">30,525</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(55,719)</span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,756 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> -2246000 13065000 22138000 -46000 1336000 109000 -2292000 14401000 22247000 29294000 -48240000 -15416000 3523000 -21880000 -3075000 32817000 -70120000 -18491000 30525000 -55719000 3756000 30525000 -55719000 3756000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group is primarily subject to taxation in the U.S. A reconciliation of the U.S. federal statutory tax rate to the effective tax rate is as follows:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:28.596%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.417%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2021</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">%</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">%</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">%</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">US federal statutory rate</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(7,573)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">21.00</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(19,486)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">21.00 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(12,380)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">21.00 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">State taxes, net of federal effect</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(3,974)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">11.01</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,043)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.67 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(4,484)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7.61 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax credits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(9,167)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">25.39</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6,876)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7.41 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(5,056)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8.58 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Stock-based compensation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">589</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1.63)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">788 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.85)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">555 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.94)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Finance income/(costs) – fair value accounting</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(556)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.54</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(28,783)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">31.02 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,017)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.42 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Loss with respect to associate for which no deferred tax asset is recognized</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">249</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(0.69)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">1,413 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1.52)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,542 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(19.58)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Revaluation of deferred due to rate change</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">0.00</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(8,856)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">9.54 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Nondeductible compensation</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">872</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2.42)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">300 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.32)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">746 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1.27)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Recognition of deferred tax assets and tax benefits not previously recognized</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(433)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1.20</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(184)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.20 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(414)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">0.70 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Unrecognized deferred tax asset</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">83,984</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(232.63)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">17,287 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(18.63)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">14,375 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(24.38)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deconsolidation of subsidiary</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(17,506)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">48.49</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,572)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3.85 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,321</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(3.65)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">293 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(0.32)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">889 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(1.51)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Worthless stock deduction</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(17,281)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">47.87</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">30,525</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(84.52)</span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(55,719)</span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">60.05 </span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:0 1pt"></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">3,756</span></td><td colspan="2" style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(6.37)</span></td><td style="border-bottom:0.5pt solid #000000;border-top:0.25pt solid #000000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> -7573000 0.2100 -19486000 0.2100 -12380000 0.2100 -3974000 0.1101 -8043000 0.0867 -4484000 0.0761 9167000 -0.2539 6876000 -0.0741 5056000 -0.0858 589000 -0.0163 788000 -0.0085 555000 -0.0094 -556000 0.0154 -28783000 0.3102 -2017000 0.0342 249000 -0.0069 1413000 -0.0152 11542000 -0.1958 0 0.0000 -8856000 0.0954 0 0 872000 -0.0242 300000 -0.0032 746000 -0.0127 433000 -0.0120 184000 -0.0020 414000 -0.0070 83984000 -2.3263 17287000 -0.1863 14375000 -0.2438 17506000 -0.4849 3572000 -0.0385 0 0 1321000 -0.0365 293000 -0.0032 889000 -0.0151 -17281000 0.4787 0 0 0 0 30525000 -0.8452 -55719000 0.6005 3756000 -0.0637 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets have been recognized in the U.S. jurisdiction in respect of the following items:</span></div><div style="margin-bottom:5.25pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td><td colspan="3" style="display:none"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Operating tax losses</span></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,849</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #000;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48,317 </span></td><td style="border-top:0.25pt solid #000;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax credits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,425</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Share-based payments</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,210</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">8,423 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Capitalized research &amp; development expenditures</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">39,422</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">36,084 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">13,036 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Lease liability</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">5,133</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">7,143 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Sale of future royalties </span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">35,920</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Other temporary differences</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,770</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">2,957 </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">93,729</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">127,061 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investments held at fair value</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(53,411)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(47,877)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Right of use assets</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(2,330)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(3,519)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Property and equipment, net</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(1,637)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(2,348)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Investment in Associates</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(755)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax liabilities</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(58,133)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(53,744)</span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets (liabilities), net</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">35,596</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">73,317 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax liabilities, net, recognized</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">(52,462)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(19,645)</span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td><td colspan="3" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets (liabilities), net, not recognized</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">88,058</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">92,962 </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="display:none"></td></tr></table></div> 3849000 48317000 2425000 11101000 5210000 8423000 39422000 36084000 0 13036000 5133000 7143000 35920000 0 1770000 2957000 93729000 127061000 53411000 47877000 2330000 3519000 1637000 2348000 755000 0 58133000 53744000 -35596000 -73317000 52462000 19645000 88058000 92962000 88058000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deferred tax assets have not been recognized in respect of the following carryforward losses, credits and temporary differences, because it is not probable that future taxable profit will be available against which the Group can use the benefits therefrom.</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" style="background-color:#ffffff;padding:0 1pt"></td><td colspan="6" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td><td colspan="3" style="padding:0 1pt"></td></tr><tr style="height:9pt"><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Gross Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Tax Effected</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Gross Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Tax Effected</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Deductible temporary difference</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">353,323</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">83,741</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">132,145 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">33,544 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax losses</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">13,681</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,849</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">219,466 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48,317 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax credits</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">468</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">468</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">367,472</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">88,058</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">362,712 </span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">92,962 </span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 353323000 83741000 132145000 33544000 13681000 3849000 219466000 48317000 468000 468000 11101000 11101000 367472000 88058000 362712000 92962000 <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax losses and tax credits for which no deferred tax asset was recognized are presented below:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:52.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.406%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="3" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">As of December 31</span></td><td colspan="6" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" style="padding:0 1pt"></td><td colspan="6" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:center"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:9pt"><td colspan="3" style="padding:0 1pt"></td></tr><tr style="height:9pt"><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Gross Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">Tax Effected</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Gross Amount</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">Tax Effected</span></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax losses expiring:</span></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Within 10 years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">4,741</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,284</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">23,930 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">5,387 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">More than 10 years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">6,635</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,455</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">42,822 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,509 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Available Indefinitely</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">2,305</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">1,110</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">152,714 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">32,421 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">13,681</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">3,849</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">219,466 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">48,317 </span></td><td style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-top:0.5pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax credits expiring:</span></td><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.5pt solid #183964;padding:0 1pt"></td><td colspan="3" style="background-color:#ffffff;border-top:0.5pt solid #183964;padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Within 10 years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">43</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">43</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">43 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">43 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">More than 10 years</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">425</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">425</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,058 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,058 </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Available indefinitely</span></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">— </span></td><td style="background-color:#ffffff;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">Total</span></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">468</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">468</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="3" style="border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:0 1pt"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">11,101 </span></td><td style="background-color:#ffffff;border-bottom:0.5pt solid #183964;border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 4741000 1284000 23930000 5387000 6635000 1455000 42822000 10509000 2305000 1110000 152714000 32421000 13681000 3849000 219466000 48317000 43000 43000 43000 43000 425000 425000 11058000 11058000 0 0 0 0 468000 468000 11101000 11101000 13681000 219466000 215400000 2305000 1396000 4500000 3900000 930000 6100000 111446000 71700000 27900000 98000 600000 1300000 <div><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Tax Balances</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The tax related balances presented in the Statement of Financial Position are as follows:</span></div><div style="margin-bottom:5pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.899%"><tr><td style="width:1.0%"></td><td style="width:75.869%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.415%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:10.416%"></td><td style="width:0.1%"></td></tr><tr style="height:9pt"><td colspan="3" rowspan="2" style="background-color:#ffffff;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">For the year ended December 31</span></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">2023</span></div><div style="text-align:right"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:7pt;font-weight:700;line-height:120%">$</span></div></td><td colspan="3" rowspan="2" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">2022</span></div><div style="text-align:right"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:7pt;font-weight:400;line-height:120%">$</span></div></td></tr><tr style="height:11pt"><td colspan="9" style="display:none"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-top:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Income tax receivable – current </span></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">11,746</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-top:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">10,040 </span></td><td style="border-top:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.25pt solid #183964;padding:2px 1pt;text-align:left;vertical-align:bottom"><div><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">Trade and other payables</span></div></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:700;line-height:120%">—</span><span style="color:#000000;font-family:'Avenir LT Pro 85 Heavy',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%"> </span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td><td colspan="2" style="border-bottom:0.25pt solid #183964;padding:2px 0 2px 1pt;text-align:right;vertical-align:bottom"><span style="color:#183964;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">(57)</span></td><td style="border-bottom:0.25pt solid #183964;padding:2px 1pt 2px 0;text-align:right;vertical-align:bottom"></td></tr></table></div> 11746000 10040000 0 57000 Subsequent Events <div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">The Group has evaluated subsequent events after December 31, 2023, up to the date of issuance, April 25, 2024, of the Consolidated Financial Statements, and has not identified any recordable or disclosable events not otherwise reported in these Consolidated Financial Statements or notes thereto, except for the following:</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In January 2024, the Group launched two new Founded Entities (Seaport Therapeutics and Gallop Oncology) to advance certain programs from the Wholly-Owned Programs segment. Seaport Therapeutics ("Seaport") will advance certain central nervous system programs and relevant Glyph intellectual property. Gallop Oncology will advance LYT-200 and other galectin-9 intellectual property. The financial results of these programs were included in the Wholly-Owned Programs segment in the footnotes to the Consolidated Financial Statements, as of December 31, 2023 and 2022, and for the three years ended December 31, 2023, 2022 and 2021, respectively. Upon raising dilutive third-party financing, the financial results of these two entities will be included in the Controlled Founded Entities segment to the extent that the Group maintains control over these entities.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">On May 9, 2022, the Group announced the commencement of a $50,000 share repurchase program ( the "Program") of its ordinary shares of one pence each. In February 2024, the Group completed the Program and has repurchased an aggregate of 20,182,863 ordinary shares under the Program. These shares have been held as treasury shares and are being used to settle the vesting of restricted stock units or exercise of options.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In March 2024, Karuna was acquired by Bristol Myers Squibb (“BMS”) in accordance with a definitive merger agreement signed in December 2023. As a result of this transaction, the Group received total proceeds of <span id="i5771117341fa4c339e6c04f3bed8c381_12477"></span>$292,672 before income tax in exchange for its holding of 886,885 shares of Karuna common stock. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In March 2024, the Group announced a proposed capital return of $100,000 to its shareholders by way of a tender offer (the "Tender Offer"). The Tender Offer is expected to be launched in early May, subject to market conditions and shareholder approval. If the full $100,000 is not returned, then the Group intends to return any remainder following the completion of the Tender Offer, by way of a special dividend.</span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In April 2024, Seaport Therapeutics, the Group's latest Founded Entity, raised $100,000 in a Series A financing, out of which $32,000 was invested by the Group. Following the Series A financing, the Group holds equity ownership in Seaport of 61.5 percent on a diluted basis. </span></div><div style="margin-bottom:5pt"><span style="color:#000000;font-family:'Avenir LT Pro 45 Book',sans-serif;font-size:8.5pt;font-weight:400;line-height:120%">In April 2024, the Gelesis' Chapter 7 Trustee provided notice that a third party bid to purchase the assets subject to the bankruptcy had been accepted as a stalking horse bid, subject to Bankruptcy Court approval. If such sale of the assets is ultimately approved by the Bankruptcy Court and consummated, it is expected that PureTech could recover a portion of its investment in Gelesis senior secured convertible promissory notes. The ultimate resolution of this matter, any potential recovery, and the associated timing remain uncertain. The Group has not recorded any amount in its Consolidated Financial Statements related to amounts that may be received as a result of the bankruptcy process.</span></div> 2 2 50000000 1 20182863 292672000 886885000 100000000 100000000 100000000 32000000 0.615